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科研机构
上海药物研究所 [8]
海洋研究所 [2]
内容类型
期刊论文 [10]
发表日期
2024 [1]
2021 [1]
2020 [2]
2018 [1]
2017 [2]
2014 [2]
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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo
期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:
Sun, Hao
;
Bai, Xiaoyi
;
Zhang, Yiting
;
Gao, Yanan
;
Dai, Jiajia
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/06/04
Anti-tumor
SHP2
Orthosteric inhibitor
Apoptosis
Bromophenol
Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cancer cells by directly targeting collagen I
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 卷号: 297, 期号: 4, 页码: 12
作者:
Liu, Ge
;
Liu, Rui
;
Shan, Yeqi
;
Sun, Chaomin
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  |  
浏览/下载:29/0
  |  
提交时间:2022/01/05
USP28 and USP25 are downregulated by Vismodegib in vitro and in colorectal cancer cell lines
期刊论文
FEBS JOURNAL, 2020, 页码: 18
作者:
Wang, Hui
;
Meng, Qian
;
Ding, Yiluan
;
Xiong, Muya
;
Zhu, Mengying
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  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
colorectal cancer
HDX-MS
inhibitor
USP25
USP28
Vismodegib
In Silico Screening-Based Discovery of Novel Inhibitors of Human Cyclic GMP-AMP Synthase: A Cross-Validation Study of Molecular Docking and Experimental Testing
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2020, 卷号: 60, 期号: 6, 页码: 3265-3276
作者:
Zhao, Wenfeng
;
Xiong, Muya
;
Yuan, Xiaojing
;
Li, Minjun
;
Sun, Hongbin
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  |  
浏览/下载:18/0
  |  
提交时间:2020/12/24
Design, synthesis and biological evaluation of benzo[cd]indo1-2(1H)-ones derivatives as BRD4 inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 264-273
作者:
Feng, Yuxin
;
Xiao, Senhao
;
Chen, Yantao
;
Jiang, Hao
;
Liu, Na
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  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
Benzo[cd]indol-2(1H)-one
Sulfonamide
BRD4 inhibitor
Bromodomain and extra-terminal domain
Acetyl-lysine binding pocket
Discovery of alkyl bis(oxy)dibenzimidamide derivatives as novel protein arginine methyltransferase 1 (PRMT1) inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2017, 卷号: 90, 期号: 6, 页码: 1260-1270
作者:
Zhang, Wei-yao
;
Lu, Wen-chao
;
Jiang, Hao
;
Lv, Zheng-bing
;
Xie, Yi-qian
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/01/08
epigenetics
molecular docking
PRMT1
scaffold hopping
small-molecule inhibitor
PI-273, a Substrate-Competitive, Specific Small-Molecule Inhibitor of PI4KII alpha, Inhibits the Growth of Breast Cancer Cells
期刊论文
CANCER RESEARCH, 2017, 卷号: 77, 期号: 22, 页码: 6253-6266
作者:
Li, Jiangmei
;
Gao, Zhen
;
Zhao, Dan
;
Zhang, Lunfeng
;
Qiao, Xinhua
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Discovery of a novel inhibitor of NAD(P)(+)-dependent malic enzyme (ME2) by high-throughput screening
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 5, 页码: 674-684
作者:
Wen, Yi
;
Xu, Lei
;
Chen, Fang-lei
;
Gao, Jing
;
Li, Jing-ya
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/01/08
malic enzyme
ME2
inhibitor
natural product
NPD389
high-throughput screening
structure-activity relationship
enzyme kinetics
thermal shift assay
Discovery of a novel inhibitor of NAD(P)~+-dependent malic enzyme (ME2) by high-throughput screening
期刊论文
Acta Pharmacologica Sinica, 2014, 卷号: 35, 期号: 5, 页码: 674
作者:
Wen Yi
;
Xu Lei
;
Chen Fanglei
;
Gao Jing
;
Li Jingya
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/07/01
THERMAL SHIFT ASSAYS
STATISTICAL PARAMETER
QUALITY-CONTROL
DRUG DISCOVERY
RNAI SCREENS
PROGRESSION
MECHANISM
HIT
ATP
malic enzyme
ME2
inhibitor
natural product
NPD389
high-throughput screening
structure-activity relationship
enzyme kinetics
thermal shift assay
Abscisic Acid Signaling: Thermal Stability Shift Assays as Tool to Analyze Hormone Perception and Signal Transduction
期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 10
作者:
Soon, Fen-Fen
;
Suino-Powell, Kelly M.
;
Li, Jun
;
Yong, Eu-Leong
;
Xu, H. Eric
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
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