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CORC

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A novel hypertensive crisis rat model established by excessive norepinephrine infusion and the potential therapeutic effects of Rho-kinase inhibitors on it 期刊论文
2019, 卷号: 109, 页码: 1867-1875
作者:  Yuan, Tian-Yi;  Chen, Di;  Chen, Yu-Cai;  Zhang, Hui-Fang;  Niu, Zi-Ran
收藏  |  浏览/下载：6/0  |  提交时间：2020/01/03
Effects of fasudil on pulmonary hypertension in clinical practice 期刊论文
Pulmonary Pharmacology and Therapeutics, 2017, 卷号: 46, 页码: 54-63
作者:  Zhang, Yiqing;  Wu, Shangjie*
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03
Pulmonary hypertension  Pulmonary arterial hypertension  Rho-kinase  Fasudil  CHD  congenital heart diseases  CI  cardiac index  CO  cardiac output  CTD  connective tissue diseases  CTEPH  chronic thromboembolic pulmonary hypertension  ERA  endothelin receptor antagonists  ET  endothelin  IPAH  idiopathic pulmonary arterial hypertension  MCT  monocrotaline  PAH  pulmonary arterial hypertension  PAP  pulmonary artery pressure  PASMC  pulmonary artery smooth muscle cells  PDEI  phosphodiesterase-5 inhibitors  PH  Pulmonary hypertension  PVR  pulmonary vascular resistance  PVR/SVR  pulmonary to systemic vascular resistance  Qp/Qs  pulmonary to systemic blood flow  RHC  right heart catheterization  ROCK  Rho-kinase  SAP  systemic artery pressure  SaO2  arterial oxygen saturation  SVR  systemic vascular resistance  SvO2  mixed venous oxygen saturation  TPR  total pulmonary resistance  6MWD  6-minute walk distance  
Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents 期刊论文
2017, 卷号: 22, 期号: 10
作者:  Yao, Yangyang;  Li, Renze;  Liu, Xiaoyu;  Yang, Feilong;  Yang, Ying
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/03
High-throughput screening against 6.1 million structurally diverse, lead-like compounds to discover novel ROCK inhibitors for cerebral injury recovery 期刊论文
MOLECULAR DIVERSITY, 2016, 卷号: 20, 期号: 2, 页码: 537-549
作者:  Gong, Haoling[1];  Yuan, Zhicheng[2];  Zhan, Liping[3]
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/24
Development of Second-Generation Small-Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy 期刊论文
CHEMMEDCHEM, 2015, 卷号: 10, 期号: 1, 页码: 193-206
作者:  Ma, Sheng;  Deng, Jing;  Li, Baoli;  Li, Xiujiang;  Yan, Zhaowei
收藏  |  浏览/下载：20/0  |  提交时间：2019/01/08
The Effect of First-in-Class Small Molecule RhoA Inhibitor, HL07, on the Phenylephrine-induced Artery Contraction 期刊论文
CURRENT PHARMACEUTICAL DESIGN, 2012, 卷号: 18, 期号: 27, 页码: 4258-4264
作者:  Zhang, Yan;  Deng, Jing;  Ma, Sheng;  Xue, Lin;  Zhu, Jin
收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08
Design and Synthesis of Small Molecule RhoA Inhibitors: A New Promising Therapy for Cardiovascular Diseases? 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 54, 期号: 13, 页码: 4508-4522
作者:  Deng, Jing;  Feng, Enguang;  Ma, Sheng;  Zhang, Yan;  Liu, Xiaofeng
收藏  |  浏览/下载：17/0  |  提交时间：2019/01/08
Synthetic osteogenic growth peptide promotes differentiation of human bone marrow mesenchymal stem cells to osteoblasts via RhoA/ROCK pathway 期刊论文
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 卷号: 358, 期号: 1, 页码: 221-227
作者:  Chen, ZX;  Wang, XF;  Shao, YC;  Shi, DY;  Chen, TY
收藏  |  浏览/下载：26/0  |  提交时间：2015/07/22
Rock2 controls TGF beta signaling and inhibits mesoderm induction in zebrafish embryos 期刊论文
2010, 2010
Zhang, Yu; Li, Xiang; Qi, Jingjing; Wang, Jialu; Liu, Xingfeng; Zhang, Haiwen; Lin, Sheng-Cai; Meng, Anming
收藏  |  浏览/下载：5/0
Molecular modeling studies of Rho kinase inhibitors using molecular docking and 3D-QSAR analysis 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2010, 卷号: 45, 期号: 7, 页码: 2768-2776
作者:  Qin, J;  Lei, BL;  Xi, LL;  Liu, HX;  Yao, XJ
收藏  |  浏览/下载：3/0  |  提交时间：2015/12/22

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