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上海药物研究所 [7]
化学研究所 [3]
山东大学 [3]
北京大学 [2]
河北省人民医院 [2]
厦门大学 [1]
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期刊论文 [18]
会议论文 [3]
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2019 [1]
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metabolismanddispositionofpyrotinibinhealthymalevolunteerscovalentbindingwithhumanplasmaprotein
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 7, 页码: 980
作者:
Meng Jian
;
Liu Xiaoyun
;
Ma Sheng
;
Zhang Hua
;
Yu Songda
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/07/01
pyrotinib
EGFR/HER2 dual tyrosine kinase inhibitor
breast cancer
drug metabolism
drug disposition
human plasma
covalent binding
Metabolism and disposition of pyrotinib in healthy male volunteers: covalent binding with human plasma protein
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Meng, Jian
;
Liu, Xiao-Yun
;
Ma, Sheng
;
Zhang, Hua
;
Yu, Song-da
收藏
  |  
浏览/下载:101/0
  |  
提交时间:2019/01/08
Synthesis and biological evaluation of novel benzofuroxan-based pyrrolidine hydroxamates as matrix metalloproteinase inhibitors with nitric oxide releasing activity
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 15, 页码: 4363-4374
作者:
Zhang, Hao
;
Wang, Xuejian
;
Mao, Jing
;
Huang, Yongxue
;
Xu, Wenfang
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/11
MMP inhibitor
Nitric oxide
Benzofuroxan
Multifunctional drugs
Synthesis
Pyrrolidine Dithiocarbamate (PDTC) Attenuates Cancer Cachexia by Affecting Muscle Atrophy and Fat Lipolysis
期刊论文
FRONTIERS IN PHARMACOLOGY, 2017, 卷号: 8
作者:
Miao, Chunxiao
;
Lv, Yuanyuan
;
Zhang, Wanli
;
Chai, Xiaoping
;
Feng, Lixing
收藏
  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
cancer cachexia
PDTC
C2C12 myotubes
3T3-L1 adipocytes
muscle atrophy
fat lipolysis
Biosynthesis of the pyrrolidine protein synthesis inhibitor anisomycin involves novel gene ensemble and cryptic biosynthetic steps
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 卷号: 114, 期号: 16
作者:
Zheng, Xiaoqing
;
Cheng, Qiuxiang
;
Yao, Fen
;
Wang, Xiaozheng
;
Kong, Lingxin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/05
pyrrolidine antibiotics
anisomycin biosynthetic pathway
protein synthesis inhibitor
cryptic glycosylation
Streptomyces
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
Journal of chromatography b-analytical technologies in the biomedical and life sciences, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/05/09
Pyrotinib
Uplc/q-tof ms
Metabolism
Human
Cyp3a4
Drug-drug interaction
Metabolic characterization of pyrotinib in humans by ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2016, 卷号: 1033, 页码: 117-127
作者:
Zhu, Yunting
;
Li, Liang
;
Zhang, Ge
;
Wan, Hong
;
Yang, Changyong
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Pyrotinib
UPLC/Q-TOF MS
Metabolism
Human
CYP3A4
Drug-drug interaction
First total synthesis of (+)-broussonetine W: glycosidase inhibition of natural product & analogs
期刊论文
ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 卷号: 14, 期号: 22, 页码: 5157-5174
作者:
Song, Ying-Ying
;
Kinami, Kyoko
;
Kato, Atsushi
;
Jia, Yue-Mei
;
Li, Yi-Xian
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/01/17
Prostaglandin E-2 accelerates invasion by upregulating Snail in hepatocellular carcinoma cells
期刊论文
TUMOR BIOLOGY, 2014, 卷号: 35, 期号: 7, 页码: 7135-7145
作者:
Zhang, M
;
Zhang, H
;
Cheng, SY
;
Zhang, DC
;
Xu, Y
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/12/22
PGE(2)
EP4 receptor
Snail
NF-kappa B
Akt
Hepatoma cell
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2013, 卷号: 21, 期号: 23, 页码: 7418-7429
作者:
Wang, Jiang
;
Feng, Ying
;
Ji, Xun
;
Deng, Guanghui
;
Leng, Ying
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Pyrrolidine-2-carbonitrile
4-Fluoropyrrolidine-2-carbonitrile
Dipeptidyl peptidase-4 inhibitor
Oral glucose tolerance test
Type 2 diabetes
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