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浏览/检索结果: 共4条，第1-4条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of thalidomide-based PROTAC small molecules as the highly efficient SHP2 degraders 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 218, 页码: 14 作者:  Yang, Xiangbo;  Wang, Zhijia;  Pei, Yuan;  Song, Ning;  Xu, Lei 收藏  |  浏览/下载：40/0  |  提交时间：2021/08/17 SHP2 degradation  Proteolysis targeting chimera (PROTAC)  Thalidomide-based heterobifunctional molecules  E3 ubiquitin ligase  CRBN   Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14 作者:  Zhang, Xin;  Xu, Fang;  Tong, Linjiang;  Zhang, Tao;  Xie, Hua 收藏  |  浏览/下载：80/0  |  提交时间：2020/07/01 Epidermal growth factor receptor (EGFR)  Resistance  Proteolysis targeting chimera (PROTAC)  Protein degradation   Discovery of QCA570 as an Exceptionally Potent and Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of the Bromodomain and Extra-Terminal (BET) Proteins Capable of Inducing Complete and Durable Tumor Regression 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 15, 页码: 6685-6704 作者:  Qin, Chong;  Hu, Yang;  Zhou, Bing;  Fernandez-Salas, Ester;  Yang, Chao-Yie 收藏  |  浏览/下载：45/0  |  提交时间：2019/01/08 Design and Synthesis of Novel Bispecific Molecules for Inducing BRD4 Protein Degradation 期刊论文 CHEMICAL RESEARCH IN CHINESE UNIVERSITIES, 2018, 卷号: 34, 期号: 1 作者:  Song Yuming;  Wang Yue;  Gao Yang;  Yu Shanshan;  Zhao Qianqian 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/05 Proteolysis targeting chimera(PROTAC)  Bromodomain-containing protein 4(BRD4) degrader  Bromodomain containing protein 4(BRD4) inhibitor