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期刊论文 [69]
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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Supramolecular Antagonists Promote Mitochondrial Dysfunction
期刊论文
NANO LETTERS, 2021, 卷号: 21, 期号: 13, 页码: 5730-5737
作者:
Li, Mingming
;
Song, Yanqiu
;
Song, Na
;
Wu, Guangyao
;
Zhou, Hao
收藏
  |  
浏览/下载:91/0
  |  
提交时间:2021/08/17
Self-Assembly
Peptides
Drug Delivery
Mitochondrion-Targeting
Antagonists
Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 卷号: 38, 期号: 4, 页码: 975-984
作者:
Xu, Heng
;
Tang, Zhengkuan
;
Zuo, Yu
;
Xiong, Fengmin
;
Chen, Kaixian
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  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
cIAP1
dimerization
conformational change
MD simulation
Human substance P receptor binding mode of the antagonist drug aprepitant by NMR and crystallography
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 8
作者:
Chen, Shuanghong
;
Lu, Mengjie
;
Liu, Dongsheng
;
Yang, Lingyun
;
Yi, Cuiying
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
期刊论文
Evidence-based Complementary & Alternative Medicine, 2019, 页码: 1-11
作者:
Guo, Yubo
;
Pei, Xiaohua
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  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
AUTOPHAGIC
vacuoles
*CALCIUM
antagonists
*CELL
proliferation
*ANIMAL
experimentation
*APOPTOSIS
*BIOLOGICAL
assay
*BREAST
tumors
*CALCIUM-binding
proteins
*CARRIER
proteins
*CELL
lines
*CELL
surface
antigens
*CELLULAR
signal
transduction
*FLUORESCENT
antibody
technique
*GENE
expression
*IMMUNODIAGNOSIS
*MICE
*PHOSPHATASES
*PHOSPHOTRANSFERASES
*PROTEINS
*STAINS
&
staining
(Microscopy)
*WESTERN
immunoblotting
*CELL
viability
*PHARMACODYNAMICS
Targeting Gpr52 lowers mutant HTT levels and rescues Huntington's disease-associated phenotypes
期刊论文
BRAIN, 2018, 卷号: 141, 页码: 1782-1798
作者:
Song, Haikun
;
Li, Hexuan
;
Guo, Shimeng
;
Pan, Yuyin
;
Fu, Yuhua
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  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
GPCR
target validation
polyQ
neurodegeneration
antagonists
Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist
期刊论文
CELL DISCOVERY, 2018, 卷号: 4
作者:
Yin, Wanchao
;
Zhou, X. Edward
;
Yang, Dehua
;
de Waal, Parker W.
;
Wang, Meitian
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  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 2, 页码: 443-454
作者:
Liu, Xiaohua
;
Zhang, Yu
;
Huang, Wenjing
;
Tan, Wenfu
;
Zhang, Ao
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2019/01/08
Bcl-2
Bcl-xL
Sulfonamide
Navitoclax
Apoptosis
Presynaptic Neuronal Pentraxin Receptor Organizes Excitatory and Inhibitory Synapses
期刊论文
JOURNAL OF NEUROSCIENCE, 2017
Lee, Sung-Jin
;
Wei, Mengping
;
Zhang, Chen
;
Maxeiner, Stephan
;
Pak, ChangHui
;
Botelho, Salome Calado
;
Trotter, Justin
;
Sterky, Fredrik H.
;
Sudhof, Thomas C.
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2017/12/03
AMPAR
cell adhesion molecule
neuronal pentraxin receptor
synaptogenesis
DEVELOPING VISUAL-SYSTEM
AMPA RECEPTORS
TERMINAL DOMAIN
NARP
NEUREXINS
NEUROLIGINS
PLASTICITY
NP1
DIFFERENTIATION
INTERNEURONS
The sphingosine-1-phosphate analogue, FTY-720, promotes the proliferation of embryonic neural stem cells, enhances hippocampal neurogenesis and learning and memory abilities in adult mice
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2016, 卷号: 173, 期号: 18, 页码: 2793-2807
作者:
Sun, Yili
;
Hong, Feng
;
Zhang, Lei
;
Feng, Linyin
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  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
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