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New monoamine antidepressant, hypidone hydrochloride (YL-0919), enhances the excitability of medial prefrontal cortex in mice via a neural disinhibition mechanism
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Yong-Mei
;
Ye, Lu-Yu
;
Li, Tian-Yu
;
Guo, Fan
;
Guo, Fei
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/01/04
YL-0919
medial prefrontal cortex
GABAergic neurons
5-HT1A receptor
GAD67-GFP transgenic mice
disinhibition
fluoxetine
electrophysiological recording
Different conformational responses of the beta(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline
期刊论文
NATIONAL SCIENCE REVIEW, 2021, 卷号: 8
作者:
Yang, Fan
;
Ling, Shenglong
;
Zhou, Yingxin
;
Zhang, Yanan
;
Lv, Pei
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/11/01
cryo-EM structure
G protein-coupled receptor (GPCR)
partial and full agonists
conformational change
desensitization
Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor
期刊论文
ELIFE, 2021, 卷号: 10, 页码: 20
作者:
Zhao, Fenghui
;
Zhang, Chao
;
Zhou, Qingtong
;
Hang, Kaini
;
Zou, Xinyu
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2021/08/17
TPN672: A Novel Serotonin-Dopamine Receptor Modulator for the Treatment of Schizophrenia
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 卷号: 378, 期号: 1, 页码: 20-30
作者:
Wang, Yu
;
He, Yang
;
Yang, Feipu
;
Abame, Melkamu Alemu
;
Wu, Chunhui
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/11/04
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Characterization of the GABAergic system in Asian clam Corbicula fluminea: Phylogenetic analysis, tissue distribution, and response to the aquatic contaminant carbamazepine
期刊论文
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2021, 卷号: 239
作者:
Chen, Huihui
;
Gu, Xiaohong
;
Zeng, Qingfei
;
Mao, Zhigang
;
Martyniuk, Christopher J.
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  |  
浏览/下载:26/0
  |  
提交时间:2022/03/10
One-day tropisetron treatment improves cognitive deficits and P50 inhibition deficits in schizophrenia
期刊论文
NEUROPSYCHOPHARMACOLOGY, 2020, 卷号: 45, 期号: 8, 页码: 1362-1368
作者:
Xia, Luyao
;
Liu, Lei
;
Hong, Xiaohong
;
Wang, Dongmei
;
Wei, Gaoxia
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  |  
浏览/下载:28/0
  |  
提交时间:2020/06/08
Synthesis and biological investigation of triazolopyridinone derivatives as potential multireceptor atypical antipsychotics
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 8, 页码: 6
作者:
Shi, Wenqiang
;
Wang, Yu
;
Wu, Chunhui
;
Yang, Feipu
;
Zheng, Wei
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2020/07/01
Triazolopyridinone
Antipsychotic
Multireceptor
5-HT1A receptor
Identification and structural insight of an effective PPAR gamma modulator with improved therapeutic index for anti-diabetic drug discovery
期刊论文
CHEMICAL SCIENCE, 2020, 卷号: 11, 期号: 8, 页码: 2260-2268
作者:
Jiang, Haowen
;
Zhou, X. Edward
;
Shi, Jingjing
;
Zhou, Zhi
;
Zhao, Guanguan
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/07/01
3-(2-Carboxyethyl)indole-2-carboxylic Acid Derivatives: Structural Requirements and Properties of Potent Agonists of the Orphan G Protein-Coupled Receptor GPR17
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 61, 期号: 18, 页码: 8136-8154
作者:
Baqi, Younis
;
Pillaiyar, Thanigaimalai
;
Abdelrahman, Aliaa
;
Kaufmann, Olesja
;
Aishaibani, Samer
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  |  
浏览/下载:105/0
  |  
提交时间:2019/01/08
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