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Systematic comparison of metabolic differences of Uncaria rhynchophylla in rat, mouse, dog, pig, monkey and human liver microsomes
期刊论文
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2020, 页码: 7
作者:
Li, Hao-Jv
;
Wei, Wen-Long
;
Li, Zhen-Wei
;
Yao, Chang-Liang
;
Wang, Meng-Yuan
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2020/12/24
Uncaria rhynchophylla
Indole alkaloids
Mass defect filter
Time-staggered targeted ion lists
Metabolite identification
Liver microsomes
Species differences in the CYP3A-catalyzed metabolism of TPN729, a novel PDE5 inhibitor
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tian, Qian-qian
;
Zhu, Yun-ting
;
Diao, Xing-xing
;
Zhang, Xiang-lei
;
Xu, Ye-chun
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2020/12/24
PDE5 inhibitor
TPN729
M3
species difference
pharmacokinetics
metabolite identification
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Two validated liquid chromatography-mass spectrometry methods with different pretreatments for the quantification of an anti-CD47 monoclonal antibody in rat and cynomolgus monkey serum compared with an electrochemiluminescence method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 175, 页码: 11
作者:
Gao, Yuxiong
;
Zhang, Dan
;
Yang, Changyong
;
Duan, Xiaotao
;
Li, Xiuli
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  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Anti-CD47 monoclonal antibody
LC-MS
Adsorption issue
Electrochemiluminescence
Pharmacokinetics
Cross-validation
Evaluation of Deuterium-Labeled JNJ38877605: Pharmacokinetic, Metabolic, and in Vivo Antitumor Profiles
期刊论文
CHEMICAL RESEARCH IN TOXICOLOGY, 2018, 卷号: 31, 期号: 11, 页码: 1213-1218
作者:
Zhan, Zhengsheng
;
Peng, Xia
;
Sun, Yiming
;
Ai, Jing
;
Duan, Wenhu
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Determination of a novel dipeptidyl peptidase IV inhibitor in monkey plasma by HPLC-MS/MS and its application in a pharmacokinetics study
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 卷号: 117, 页码: 99-103
Deng, Jifeng
;
Guo, Jiayin
;
Dai, Renke
;
Zhang, Guicheng
;
Xie, Hui
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  |  
浏览/下载:21/0
  |  
提交时间:2016/12/16
Determination of a novel dipeptidyl peptidase IV inhibitor in monkey plasma by HPLC-MS/MS and its application in a pharmacokinetics study
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 卷号: 117, 页码: 99-103
作者:
Deng, Jifeng
;
Guo, Jiayin
;
Dai, Renke
;
Zhang, Guicheng
;
Xie, Hui
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  |  
浏览/下载:18/0
  |  
提交时间:2018/12/13
Metabolism by conjugation appears to confer resistance to paracetamol (acetaminophen) hepatotoxicity in the cynomolgus monkey
期刊论文
XENOBIOTICA, 2015, 卷号: 45, 期号: 3, 页码: 270-277
作者:
Yu, Hong
;
Barrass, Nigel
;
Gales, Sonya
;
Lenz, Eva
;
Parry, Tony
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
Cynomolgus monkeys
detoxification by glucuronidation
paracetamol toxicity
Peripheral administration of kisspeptin antagonist does not alter basal plasma testosterone but decreases plasma adiponectin levels in adult male rhesus macaques
期刊论文
TURKISH JOURNAL OF BIOLOGY, 2014, 卷号: 38, 期号: 4, 页码: 450-456
作者:
Huma T[*]
;
Ulla F
;
Hanif F
;
Rizak JD
;
Shahab M
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2014/10/16
rhesus monkey
adiponectin
reproduction
Kisspeptin
peptide 234
testosterone
Pharmacokinetic study of baicalein after oral administration in monkeys
期刊论文
2012, 卷号: 83, 期号: 3, 页码: 532-540
作者:
Tian, Shuo
;
He, Guorong
;
Song, Junke
;
Wang, Subo
;
Xin, Wenyu
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
Baicalein
Baicalin
Pharmacokinetics
Monkey plasma
LC-MS
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