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上海药物研究所 [5]
中国医学科学院 北京... [2]
清华大学 [1]
北京大学 [1]
西双版纳热带植物园 [1]
昆明植物研究所 [1]
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期刊论文 [15]
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Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 51, 页码: 5
作者:
Wang, Leiming
;
Li, Xin
;
Cui, Hong
;
Lei, Xinsheng
;
Liu, Hongchun
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2021/12/01
Marine nature products
Plocabulin
PM060184
Synthesis
Antiproliferation
Novel carbazole sulfonamide microtubule-destabilizing agents exert potent antitumor activity against esophageal squamous cell carcinoma
期刊论文
2018, 卷号: 420, 页码: 60-71
作者:
Niu, Fangfei
;
Liu, Yonghua
;
Jing, Zongpan
;
Han, Gaijing
;
Sun, Lianqi
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2020/01/03
Microtubule destabilizing agents
Esophageal squamous cell carcinoma
Antitumor effect
Apoptosis
Vascular disrupting agents
Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum
期刊论文
TETRAHEDRON, 2017, 卷号: 73, 页码: 5900-5911
作者:
Chen, Li
;
Zhao, Yang-Yang
;
Lan, Rong-Feng
;
Du, Lin
;
Wang, Bing-Shuai
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/11/21
Conformation analysis
Microtubule-destabilizing
Polyketide
Marine-derived fungus
Structure elucidation
Dicitrinone D, an antimitotic polyketide isolated from the marine-derived fungus Penicillium citrinum
期刊论文
2017, 卷号: 73, 期号: 40, 页码: 5900-5911
作者:
Chen, Li
;
Zhao, Yang-Yang
;
Lan, Rong-Feng
;
Du, Lin
;
Wang, Bing-Shuai
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/03
Marine-derived fungus
Polyketide
Structure elucidation
Conformation analysis
Microtubule-destabilizing
Molecular chaperone CCT3 supports proper mitotic progression and cell proliferation in hepatocellular carcinoma cells
期刊论文
CANCER LETTERS, 2016, 卷号: 372, 期号: 1, 页码: 101-109
作者:
Zhang, Yuanyuan
;
Wang, Yuqi
;
Wei, Youheng
;
Wu, Jiaxue
;
Zhang, Pingzhao
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  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Chaperonin
CCT3
Hepatocellular carcinoma
Microtubule
Vincristine
YSL-12, a novel microtubule-destabilizing agent, exerts potent anti-tumor activity against colon cancer in vitro and in vivo
期刊论文
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2016, 卷号: 77, 页码: 1217-1229
作者:
Cai, De[1]
;
Qiu, Zhiqing[1]
;
Yao, Weimin[2]
;
Liu, Yuyu[3]
;
Huang, Haixiang[4]
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/04/24
Microtubules
Cytotoxicity
Cell cycle
Apoptosis
Metabolic stability
In vivo anti-tumor activity
Stathmin destabilizing microtubule dynamics promotes malignant potential in cancer cells by epithelial-mesenchymal transition
期刊论文
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL, 2014, 卷号: 13, 期号: 4
作者:
Lu, Yu
;
Liu, Chen
;
Xu, Yong-Feng
;
Cheng, He
;
Shi, Si
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/19
stathmin
microtubule dynamics
epithelial-mesenchymal transition
malignant potential
cancer
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
作者:
Zhao, Yu
;
Su, Jia
;
Goto, Masuo
;
Morris-Natschke, Susan L.
;
Li, Yan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2013/10/16
Natural-products
Biological-activity
Cancer-therapy
Paclitaxel
Taxol
Resistance
Drugs
Chemotherapy
Parthenolide
Brevifoliol
SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface
期刊论文
human molecular genetics, 2013
Wang, Jingjing
;
Shan, Chunyan
;
Cao, Wenyuan
;
Zhang, Chen
;
Teng, Junlin
;
Chen, Jianguo
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/13
MICROTUBULE-DESTABILIZING ACTIVITY
GROWTH-ASSOCIATED PROTEIN
BETA-SECRETASE CLEAVAGE
ALZHEIMERS-DISEASE
AXONAL-TRANSPORT
GAMMA-SECRETASE
MOUSE MODEL
RAT-BRAIN
IN-VITRO
STATHMIN
Dual-Functional abeo-Taxane Derivatives Destabilizing Microtubule Equilibrium and Inhibiting NF-kappa B Activation
期刊论文
J. Med. Chem., 2013, 卷号: 56, 期号: 11, 页码: 4749-4757
赵昱
;
苏佳
;
GOTO MASUO
;
MORRISNATSCHKE SUSAN L
;
李艳
;
赵勤实
;
姚祝军
;
LEE KUOHSIUNG
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2014/10/16
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