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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability
期刊论文
MOLECULAR CELL, 2021, 卷号: 81, 期号: 13, 页码: 2736-+
作者:
Pan, Qiang
;
Zhong, Shanshan
;
Wang, Hanling
;
Wang, Xuege
;
Li, Ni
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浏览/下载:74/0
  |  
提交时间:2021/11/04
Nitrogen-containing bisphosphonate-loaded micro-arc oxidation coating for biodegradable magnesium alloy pellets inhibits osteosarcoma through targeting of the mevalonate pathway
期刊论文
ACTA BIOMATERIALIA, 2021, 卷号: 121, 页码: 682-694
作者:
Li, Mei
;
Yao, Mengyu
;
Wang, Weidan
;
Wan, Peng
;
Chu, Xiao
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  |  
浏览/下载:22/0
  |  
提交时间:2021/03/15
Magnesium alloy pellets
Bisphosphonates coating
Osteosarcoma
Multicellular spheroids model
Mevalonate pathway
Combining mutagenesis on Glu281 of prenyltransferase NovQ and metabolic engineering strategies for the increased prenylated activity towards menadione
期刊论文
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 2020
作者:
Ni, Wenfeng
;
Zheng, Zhiming
;
Liu, Hui
;
Wang, Peng
;
Wang, Han
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  |  
浏览/下载:26/0
  |  
提交时间:2020/11/26
Prenyltransferase NovQ
Menadione hydroquinol
Site-directed mutagenesis
Mevalonate pathway
Metabolic engineering
Transcriptome analysis identifies key genes involved in carotenoid biosynthesis in the flesh of red pummelo (Citrus maxima)
期刊论文
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT, 2020, 卷号: 34, 期号: 1
作者:
Wang, Dongxia
;
Li, Shiming
;
Wei, Le
;
Li, Zongren
;
Liu, Baolong
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  |  
浏览/下载:15/0
  |  
提交时间:2020/11/25
Pummelo
red flesh
carotenoid biosynthesis
transcriptome analysis
bHLH
Enabling Heterologous Synthesis of Lupulones in the Yeast Saccharomyces cerevisiae
期刊论文
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2019, 卷号: 188, 期号: 3, 页码: 787-797
作者:
Guo, Xiaojia
;
Shen, Hongwei
;
Liu, Yuxue
;
Wang, Qian
;
Wang, Xueying
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  |  
浏览/下载:66/0
  |  
提交时间:2019/12/02
Chemical genetics
Lupulones
Metabolic engineering
Mevalonate pathway
Saccharomyces cerevisiae
Characterization of a sesquiterpene cyclase from the glandular trichomes of Leucosceptrum canum for sole production of cedrol in Escherichia coli and Nicotiana benthamiana
期刊论文
PHYTOCHEMISTRY, 2019, 卷号: 162, 页码: 121-128
作者:
Luo, Fei
;
Ling, Yi
;
Li, De-Sen
;
Tang, Ting
;
Liu, Yan-Chun
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  |  
浏览/下载:55/0
  |  
提交时间:2019/07/29
Leucosceptrum canum
Lamiaceae
Cedrol
Sesquiterpene cylase
Cedrol synthase
Heterologous production
Synthetic biology
Bio-based squalene production by Aurantiochytrium sp. through optimization of culture conditions, and elucidation of the putative biosynthetic pathway genes.
期刊论文
Bioresource Technology, 2019, 卷号: Vol.287, 页码: 121415
作者:
Zhang, Aiqing
;
Xie, Yunxuan
;
He, Yaodong
;
Wang, Weijun
;
Sen, Biswarup
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  |  
浏览/下载:4/0
  |  
提交时间:2019/11/21
Bioresource
Mevalonate pathway, RT-qPCR
Orthogonal-design
Transcriptome
Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory
期刊论文
Microbial Cell Factories, 2019, 卷号: Vol.18 No.1, 页码: 1-9
作者:
Chuanbo Zhang
;
Man Li
;
Guang-Rong Zhao
;
Wenyu Lu
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  |  
浏览/下载:3/0
  |  
提交时间:2019/11/21
Alpha-Terpineol
Monoterpene
Synthetic biology
Saccharomyces cerevisiae
Mevalonate pathway
Zoledronic acid enhances the efficacy of the MEK inhibitor trametinib in KRAS mutant cancers
期刊论文
Cancer Letters, 2019, 卷号: Vol.442, 页码: 202-212
作者:
Xinyu Dai
;
Hongwei Xia
;
Sheng Zhou
;
Qiulin Tang
;
Feng Bi
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  |  
浏览/下载:8/0
  |  
提交时间:2019/02/28
RAS
MEK
Trametinib
Zoledronic
acid
Mevalonate
pathway
Endogenous sterol intermediates of the mevalonate pathway regulate HMGCR degradation and SREBP-2 processing[S]
期刊论文
JOURNAL OF LIPID RESEARCH, 2019, 卷号: 60, 期号: 10
作者:
Chen, Liang
;
Ma, Mei-Yan
;
Sun, Ming
;
Jiang, Lu-Yi
;
Zhao, Xue-Tong
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  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
mevalonate
lanosterol
sterol intermediates
3-hydroxy-3-methylglutaryl-coenzyme A reductase degradation
sterol regulatory element-binding protein-2 cleavage
clustered regularly interspaced short palindromic repeats (CRISPR)
CRISPR associated protein 9 (Cas9)
sterol regulatory element-binding protein-2
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