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北京大学 [7]
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期刊论文 [24]
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The Distinct Functions of Dopaminergic Receptors on Pain Modulation: A Narrative Review
期刊论文
NEURAL PLASTICITY, 2021, 卷号: 2021, 页码: 11
作者:
Wang, Xia-qing
;
Mokhtari, Tahmineh
;
Zeng, Yu-xuan
;
Yue, Lu-peng
;
Hu, Li
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2021/04/30
Automated design and optimization of multitarget schizophrenia drug candidates by deep learning
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 204, 页码: 16
作者:
Tan, Xiaoqin
;
Jiang, Xiangrui
;
He, Yang
;
Zhong, Feisheng
;
Li, Xutong
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/12/21
Schizophrenia
Multitarget antipsychotic drugs
Recurrent neural network
Multitask deep neural network
Automated drug design
Reprogramming Tumor Immune Microenvironment (TIME) and Metabolism via Biomimetic Targeting Codelivery of Shikonin/JQ1
期刊论文
NANO LETTERS, 2019, 卷号: 19, 期号: 5, 页码: 2935-2944
作者:
Wang, Hairui
;
Tang, Yisi
;
Fang, Yuefei
;
Zhang, Meng
;
Wang, Huiyuan
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  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Biomimetic delivery
glucose metabolism
immunogenic cell death (ICD)
tumor-associated macrophage
shikonin
JQ1
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
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  |  
浏览/下载:56/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Computational Multitarget Drug Design
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2017
Zhang, Weilin
;
Pei, Jianfeng
;
Lai, Luhua
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  |  
浏览/下载:9/0
  |  
提交时间:2017/12/03
DE-NOVO DESIGN
PROTEIN-COUPLED RECEPTORS
TARGET PREDICTION
IN-SILICO
SMALL-MOLECULE
BINDING-SITES
POLYPHARMACOLOGICAL PROFILES
MULTIPLE LIGANDS
WEB SERVER
OLD DRUGS
Development of Multifunctional Pyrimidinylthiourea Derivatives as Potential Anti-Alzheimer Agents
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8326-8344
作者:
Li, Xiaokang
;
Wang, Huan
;
Lu, Zhengyu
;
Zheng, Xinyu
;
Ni, Wei
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  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Design, synthesis, and biological characterization of tamibarotene analogs as anticancer agents
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 4, 页码: 542-555
作者:
Jiang, Yuqi
;
Li, Xiaoyang
;
Wang, Xue
;
Wang, Zhonglan
;
Zhang, Jian
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/16
anticancer
histone deacetylases
multitarget drugs
retinoids
tamibarotene
Salvia miltiorrhiza: A source for anti-Alzheimer's disease drugs
期刊论文
PHARMACEUTICAL BIOLOGY, 2016, 卷号: 54, 期号: 1, 页码: 18-24
作者:
Zhang, Xiu-Zhen
;
Qian, Shao-Song
;
Zhang, Yue-Jie
;
Wang, Rui-Qi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
Anti-amyloid-beta
anti-apoptosis
anti-inflammation
antioxidant
multitarget
neurogenesis
neuroprotection
Systematic synergy modeling: understanding drug synergy from a systems biology perspective
期刊论文
BMC SYSTEMS BIOLOGY, 2015, 卷号: 9
作者:
Chen, Di
;
Liu, Xi
;
Yang, Yiping
;
Yang, Hongjun
;
Lu, Peng
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  |  
浏览/下载:24/0
  |  
提交时间:2015/11/04
A beta regulation-based multitarget strategy for drug discovery against Alzheimer's disease
期刊论文
REVIEWS IN THE NEUROSCIENCES, 2015, 卷号: 26, 期号: 1, 页码: 13-30
作者:
Guo, Xiaodan
;
Jiang, Wei
;
Li, Chenjing
;
Zhu, Zhiyuan
;
Shen, Xu
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
acetyl cholinesterase
Alzheimer's disease
autophagy
beta-amyloid
ER stress
lifespan
multitarget
oxidative stress
secretase
tau protein
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