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Loss of RPS27a expression regulates the cell cycle, apoptosis, and proliferation via the RPL11-MDM2-p53 pathway in lung adenocarcinoma cells
期刊论文
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2022, 卷号: 41, 期号: 1, 页码: 20
作者:
Li, Hongyan
;
Zhang, Hong
;
Huang, Guomin
;
Bing, Zhitong
;
Xu, Duling
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2022/04/11
Ribosomal protein S27a (RPS27a)
Lung adenocarcinoma
Apoptosis
Recent Progress and Clinical Development of Inhibitors that Block MDM4/p53 Protein-Protein Interactions
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 15, 页码: 10621-10640
作者:
Zhang, Shiyan
;
Lou, Jianfeng
;
Li, Yafang
;
Zhou, Feilong
;
Yan, Ziqin
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  |  
浏览/下载:66/0
  |  
提交时间:2021/11/04
Heavy ion radiation-induced DNA damage mediates apoptosis via the Rp127a-Rp15-MDM2-p53/E2F1 signaling pathway in mouse spermatogonia
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2020, 卷号: 201, 页码: 12
作者:
Li, Hongyan
;
Zhang, Hong
;
Huang, Guomin
;
Dou, Zhihui
;
Xie, Yi
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  |  
浏览/下载:29/0
  |  
提交时间:2022/01/12
Ionizing radiation
Reproductive toxicology
Ribosomal stress
MDM2-p53 loop
Apoptosis
Targeting MDMX for Cancer Therapy: Rationale, Strategies, and Challenges
期刊论文
FRONTIERS IN ONCOLOGY, 2020, 卷号: 10
作者:
Yu, De-Hua
;
Xu, Zhi-Yuan
;
Mo, Shaowei
;
Yuan, Li
;
Cheng, Xiang-Dong
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  |  
浏览/下载:21/0
  |  
提交时间:2020/10/26
MDMX
MDM2
p53
oncogene
tumor suppressor
inhibitors
Inhibiting mechanism of small molecule toward the p53-MDM2 interaction: A molecular dynamic exploration
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 4, 页码: 1763-1777
作者:
Chen, Jianzhong
;
Wang, Jinan
;
Pang, Laixue
;
Zhu, Weiliang
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  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
hydrophobic contact scanning
MM-GBSA
p53-MDM2 interaction
principal component analysis
solvated interaction energy
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Effect of the Flexible Regions of the Oncoprotein Mouse Double Minute X on Inhibitor Binding Affinity
期刊论文
BIOCHEMISTRY, 2017, 卷号: 56, 期号: 44, 页码: 5943-5954
作者:
Chen, Yao
;
Huang, Yongqi
;
Qin, Lingyun
;
Su, Zhengding
;
Liu, Huili
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  |  
浏览/下载:27/0
  |  
提交时间:2017/12/26
A Fusion Protein of the p53 Transaction Domain and the p53-Binding Domain of the Oncoprotein MdmX as an Efficient System for High-Throughput Screening of MdmX Inhibitors
期刊论文
BIOCHEMISTRY, 2017, 卷号: 56, 期号: 25, 页码: 3273-3282
作者:
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2017/12/06
MDM2 binding protein as a predictor of metastasis and a novel prognostic biomarker in patients with gastric cancer
期刊论文
ONCOLOGY LETTERS, 2017, 卷号: 14, 期号: 6
作者:
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
MDM2 binding protein
gastric cancer
immunohistochemistry
prognosis
Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like alpha-Helical Mimetics
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 7, 页码: 3152-3162
作者:
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  |  
浏览/下载:35/0
  |  
提交时间:2016/07/12
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