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上海药物研究所 [8]
北京大学 [2]
合肥物质科学研究院 [2]
化学研究所 [1]
四川大学 [1]
复旦大学上海医学院 [1]
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期刊论文 [17]
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2012 [2]
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GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Zhang, Qing
;
Chen, Lin-hai
;
Yang, Hui
;
Fang, You-chen
;
Wang, Si-wei
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2022/01/18
GPR84
medium chain fatty acid receptor
GPCR
inflammatory bowel diseases
ulcerative colitis
NLRP3 inflammasome
macrophages
SAF-248, a novel PI3K delta-selective inhibitor, potently suppresses the growth of diffuse large B-cell lymphoma
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 11
作者:
Zhang, Xi
;
Duan, Yu-ting
;
Wang, Yi
;
Zhao, Xing-dong
;
Sun, Yi-ming
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2021/05/24
PI3Kδ
PI3K
AKT
mTOR
diffuse large B-cell lymphoma
resistance
combination therapy
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling
期刊论文
BIOCHEMICAL PHARMACOLOGY, 2020, 卷号: 177, 页码: 15
作者:
Li, Heng
;
Li, Jian
;
Zhang, Xianglei
;
Feng, Chunlan
;
Fan, Chen
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2020/12/24
DC591017
PDE4
Inflammation
Macrophages
Dendritic cells
Psoriasis
Isoforskolin and forskolin attenuate lipopolysaccharide-induced inflammation through TLR4/MyD88/NF-κB cascades in human mononuclear leukocytes.
期刊论文
Phytotherapy research, 2019
作者:
Xiaohua Du
;
Rui Shi
;
Youlan Wang
;
Wenjuang Wu
;
Shibo Sun
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/13
FSK
ISOF
MyD88
NF-κB
TLR4
inflammation
Discovery of (S)-2-amino-N-(5-(6-chloro-5-(3-methylphenylsulfonamido)pyridin-3-yl)-4-methylthiazol-2-yl)-3-methylbutanamide (CHMFL-PI3KD-317) as a potent and selective phosphoinositide 3-kinase delta (PI3K delta) inhibitor
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 156, 页码: 831-846
作者:
Liang, Xiaofei
;
Li, Feng
;
Chen, Cheng
;
Jiang, Zongru
;
Wang, Aoli
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  |  
浏览/下载:16/0
  |  
提交时间:2019/12/10
PI3K delta
Kinase inhibitor
Acute myeloid leukemia
Structure-activity relationship
Leukocyte-derived biomimetic nanoparticulate drug delivery systems for cancer therapy
期刊论文
ACTA PHARMACEUTICA SINICA B, 2018, 卷号: 8, 期号: 1
作者:
Gao, Xiaoling
;
Huang, Yukun
;
Chen, Jun
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  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Leukocytes
Tumor
Biomimetic carrier
Nanoparticulate drug delivery systems
Nanotherapeutics
Cancer therapy
Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances
期刊论文
ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651
作者:
Liu, Xiaochuan
;
Wang, Aoli
;
Liang, Xiaofei
;
Chen, Cheng
;
Liu, Juanjuan
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2017/11/16
Pi3k Delta
Leukemia
B-cell Malignances
Pi3k
Kinase Inhibitors
Discovery and Characterization of a Novel Small-Molecule Agonist for Medium-Chain Free Fatty Acid Receptor G Protein-Coupled Receptor 84
期刊论文
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2016, 卷号: 357, 期号: 2, 页码: 337-344
作者:
Zhang, Qing
;
Yang, Hui
;
Li, Jing
;
Xie, Xin
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Identification of the ortho-Benzoquinone Intermediate of 5-O-Caffeoylquinic Acid In Vitro and In Vivo: Comparison of Bioactivation under Normal and Pathological Situations
期刊论文
DRUG METABOLISM AND DISPOSITION, 2012, 卷号: 40, 期号: 8, 页码: 1628-1640
作者:
Xie, Cen
;
Zhong, Dafang
;
Chen, Xiaoyan
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  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
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