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Oridonin inhibits DNMT3A R882 mutation-driven clonal hematopoiesis and leukemia by inducing apoptosis and necroptosis 期刊论文
CELL DEATH DISCOVERY, 2021, 卷号: 7, 期号: 1, 页码: 12
作者:  Liao, Min;  Dong, Qiongye;  Chen, Ruiqing;  Xu, Liqian;  Jiang, Yuxuan
收藏  |  浏览/下载：36/0  |  提交时间：2021/12/01
Discovery of a highly potent kinase inhibitor capable of overcoming multiple imatinib-resistant ABL mutants for chronic myeloid leukemia (CML) 期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 卷号: 897
作者:  Lu, Tingting;  Cao, Jiangyan;  Zou, Fengming;  Li, Xixiang;  Wang, Aoli
收藏  |  浏览/下载：45/0  |  提交时间：2021/04/26
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity 期刊论文
BMC Cancer, 2019, 卷号: 19, 期号: 1
作者:  Wang,Ning;  Fan,Yanhua;  Yuan,Chun-Mao;  Song,Jialei;  Yao,Yao
收藏  |  浏览/下载：86/0  |  提交时间：2019/08/13
Synthesis and biological evaluation of 3-aryl-4-indolyl-maleimides as potent mutant isocitrate dehydrogenase-1 inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 4, 页码: 589-603
作者:  Liu, Xiaoqi;  Hu, Yuanyuan;  Gao, Anhui;  Xu, Meng;  Gao, Lixin
收藏  |  浏览/下载：31/0  |  提交时间：2020/07/01
Discovery and biological evaluation of thiobarbituric derivatives as potent p300/CBP inhibitors 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 20, 页码: 5397-5407
作者:  Lu, Wenchao;  Xiong, Huan;  Chen, Yu;  Wang, Chen;  Zhang, Hao
收藏  |  浏览/下载：143/0  |  提交时间：2019/01/08
High-Level Expression, Purification and Large-Scale Production of L-Methionine gamma-Lyase from Idiomarina as a Novel Anti-Leukemic Drug 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 8, 页码: 5492-5507
作者:  Huang, Kui-Ying;  Hu, Hai-Yan;  Tang, Yan-Lai;  Xia, Feng-Geng;  Luo, Xue-Qun
收藏  |  浏览/下载：75/0  |  提交时间：2016/11/02
High-Level Expression, Purification and Large-Scale Production of L-Methionine gamma-Lyase from Idiomarina as a Novel Anti-Leukemic Drug 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 期号: 8, 页码: 5492-5507
作者:  Huang, Kui-Ying;  Hu, Hai-Yan;  Tang, Yan-Lai;  Xia, Feng-Geng;  Luo, Xue-Qun
收藏  |  浏览/下载：68/0  |  提交时间：2016/11/02
High-Level Expression, Purification and Large-Scale Production of L-Methionine gamma-Lyase from Idiomarina as a Novel Anti-Leukemic Drug (SCI收录) 期刊论文
MARINE DRUGS, 2015, 卷号: 13, 页码: 5492-5507
作者:  Huang, Kui-Ying[1,2];  Hu, Hai-Yan[2];  Tang, Yan-Lai[3];  Xia, Feng-Geng[2];  Luo, Xue-Qun[3]
收藏  |  浏览/下载：4/0  |  提交时间：2019/04/25
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  
FTY720 Induces Apoptosis of M2 Subtype Acute Myeloid Leukemia Cells by Targeting Sphingolipid Metabolism and Increasing Endogenous Ceramide Levels 期刊论文
PLOS ONE, 2014, 卷号: 9, 期号: 7
作者:  Chen, Limin;  Luo, Liu-Fei;  Lu, Junyan;  Li, Lianchun;  Liu, Yuan-Fang
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08

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