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The effect of EGFR-TKIs on survival in advanced non-small-cell lung cancer with EGFR mutations: A real-world study
期刊论文
CANCER MEDICINE, 2022
作者:
Yu, Xiaoqing
;
Si, Jinfei
;
Wei, Jingwen
;
Wang, Yanling
;
Sun, Yan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/23
EGFR-TKIs
non-small cell lung cancer (NSCLC)
real-world study
survival outcome
LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo
期刊论文
CANCER SCIENCE, 2021, 页码: 12
作者:
Liu, Yingqiang
;
Lai, Mengzhen
;
Li, Shan
;
Wang, Yanan
;
Feng, Fang
收藏
  |  
浏览/下载:62/0
  |  
提交时间:2022/01/18
C797S
epidermal growth factor receptor
fourth-generation EGFR TKI
non-small cell lung cancer
osimertinib resistance
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 16, 页码: 6
作者:
Su, Zhicheng
;
Yang, Tingyuan
;
Wang, Jie
;
Lai, Mengzhen
;
Tong, Linjiang
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/24
EGFR
NSCLC
C797S
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidines as new reversible inhibitors of EGFR C797S (Cys797 to Ser797) mutant
期刊论文
CHINESE CHEMICAL LETTERS, 2020, 卷号: 31, 期号: 5, 页码: 1281-1287
作者:
Hu, Xianglong
;
Xun, Qiuju
;
Zhang, Tao
;
Zhu, Su-Jie
;
Li, Qian
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2020/07/01
EGFR(C797S) mutant
SARs
2-Oxo-3,4-dihydropyrimido[4,5-d] pyrimidine
Clinical resistance
Fourth-generation inhibitors
Design and synthesis of selective degraders of EGFR(L858R/T790M) mutant
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 14
作者:
Zhang, Xin
;
Xu, Fang
;
Tong, Linjiang
;
Zhang, Tao
;
Xie, Hua
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2020/07/01
Epidermal growth factor receptor (EGFR)
Resistance
Proteolysis targeting chimera (PROTAC)
Protein degradation
EGFR exon 20 insertion mutations in non-small cell lung cancer
期刊论文
TRANSLATIONAL CANCER RESEARCH, 2020, 卷号: 9
作者:
Wang, Fenfang
;
Li, Chenghui
;
Wu, Qihuan
;
Lu, Hongyang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/11/26
EGFR exon 20 insertion mutations
non-small cell lung cancer (NSCLC)
EGFR-TKIs
structural features
clinical features
treatment
prognosis
PD-L1 expression and T cells infiltration in patients with uncommon EGFR-mutant non-small cell lung cancer and the response to immunotherapy
期刊论文
LUNG CANCER, 2020, 卷号: 142
作者:
Chen, Kaiyan
;
Cheng, Guoping
;
Zhang, Fanrong
;
Zhu, Guanxia
;
Xu, Yanjun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/11/26
Uncommon EGFR
Non-small cell lung cancer
PD-L1
T cell
Immunotherapy
Structure-Based Design of 5-Methylpyrimidopyridone Derivatives as New Wild-Type Sparing Inhibitors of the Epidermal Growth Factor Receptor Triple Mutant (EGFR(L858R/T790M/C797S))
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 15, 页码: 7302-7308
作者:
Shen, Jiayi
;
Zhang, Tao
;
Zhu, Su-Jie
;
Sun, Min
;
Tong, Linjiang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/07/01
Discovery of Potent and Noncovalent Reversible EGFR Kinase Inhibitors of EGFR(L858R/T790M/C797S)
期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 10, 期号: 6, 页码: 869-873
作者:
Li, Qiannan
;
Zhang, Tao
;
Li, Shiliang
;
Tong, Linjiang
;
Li, Junyu
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
EGFR
mutant
inhibitor
C797S
Leptomeningeal metastasis after effective first-generation EGFR TKI treatment of advanced non-small cell lung cancer
期刊论文
Lung Cancer, 2019, 卷号: Vol.127, 页码: 1-5
作者:
Ya-Lan Wu
;
Qian Zhao
;
Lei Deng
;
Yan Zhang
;
Xiao-Juan Zhou
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/02/25
Non-small
cell
lung
cancer
Leptomeningeal
metastasis
Epidermal
growth
factor
receptor
tyrosine
kinase
inhibitor
Exon
19
deletion
L858R
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