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TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery
期刊论文
DRUG DISCOVERY TODAY, 2021, 卷号: 26, 期号: 10, 页码: 2445-2455
作者:
Xiang, Shuang
;
Song, Shukai
;
Tang, Haotian
;
Smaill, Jeff B.
;
Wang, Aiqun
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/12/01
Antibiotic resistance
Computational biology
Databases
In silico tools
Pharmacological inhibition of NF-kappa B-inducing kinase (NIK) with small molecules for the treatment of human diseases
期刊论文
RSC MEDICINAL CHEMISTRY, 2021, 卷号: 12, 期号: 4, 页码: 552-565
作者:
Cheng, Jing
;
Feng, Xuexin
;
Li, Zhiqiang
;
Zhou, Feilong
;
Yang, Jin-Ming
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  |  
浏览/下载:15/0
  |  
提交时间:2021/08/17
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Yu, Yan-yan
;
Cui, Shi-chao
;
Zheng, Tian-nan
;
Ma, Hai-jian
;
Xie, Zhi-fu
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  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
insulin resistance
sarsasapogenin
adipose tissue inflammation
macrophage-adipocyte crosstalk
IKK/NF-kappa B
JNK
Discovery of a Potent and Selective NF-kappa B-Inducing Kinase (NIK) Inhibitor That Has Anti-inflammatory Effects in Vitro and in Vivo
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 8, 页码: 4388-4407
作者:
Li, Zhiqiang
;
Li, Xinzhi
;
Su, Ming-Bo
;
Gao, Li-Xin
;
Zhou, Yu-Bo
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  |  
浏览/下载:32/0
  |  
提交时间:2020/07/01
Anti-inflammatory effect of Acalypha australis L. via suppression of NF-kappa B signaling in LPS-stimulated RAW 264.7 macrophages and LPS-induced septic mice
期刊论文
MOLECULAR IMMUNOLOGY, 2020, 卷号: 119, 页码: 123-131
作者:
Kim, Hyo-Jung
;
Joe, Hae-In
;
Zhang, Zhiyun
;
Lee, Sang Woo
;
Lee, Kyou-Young
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  |  
浏览/下载:36/0
  |  
提交时间:2022/03/01
Acalypha australis L.
Anti-inflammation
Lipopolysaccharide
NF-kappa B
RAW 264.7 macrophages
Septic shock
IKK epsilon-like plays an important role in the innate immune signaling of the Pacific oyster (Crassostrea gigas)
期刊论文
FISH & SHELLFISH IMMUNOLOGY, 2019, 卷号: 93, 页码: 551-558
作者:
Huang, Baoyu
;
Tang, Xueying
;
Zhang, Linlin
;
Li, Li
;
Wang, Wei
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  |  
浏览/下载:94/0
  |  
提交时间:2020/01/03
Oyster
Innate immunity
IKKe
TBK1
NF-kappa B
IRF
Transcriptional repression of IKK beta by p53 in arsenite-induced GADD45 alpha accumulation and apoptosis
期刊论文
ONCOGENE, 2019, 卷号: 38, 期号: 5, 页码: 731-746
作者:
Hu, Yongliang
;
Jin, Rui
;
Gao, Ming
;
Xu, Huan
;
Zou, Shuxian
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  |  
浏览/下载:13/0
  |  
提交时间:2020/10/21
Medullary thymic epithelial NF-kB-inducing kinase (NIK)/IKK alpha pathway shapes autoimmunity and liver and lung homeostasis in mice
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 卷号: 116, 期号: 38
作者:
Shen, Hong
;
Ji, Yewei
;
Xiong, Yi
;
Kim, Hana
;
Zhong, Xiao
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/05
NIK and IKKalpha
autoimmune disease
thymic epithelial cells
liver disease
lung disease
Enhanced interaction between SEC2 mutant and TCR V induces MHC II-independent activation of T cells via PKC/NF-B and IL-2R/STAT5 signaling pathways
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 51, 页码: 19771-19784
作者:
Fu, Xuanhe
;
Xu, Mingkai
;
Song, Yubo
;
Li, Yongqiang
;
Zhang, Huiwen
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2019/06/04
interleukin
NF-B (NF-KB)
STAT transcription factor
signaling
signal transduction
IL-2
staphylococcal enterotoxin C2
superantigen
T-cell receptor
T-cell activation
Cirsitakaoside isolated from Prenma szemaoensis reduces LPS-induced inflammatory responses in vitro and in vivo
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2018, 卷号: 59, 页码: 384-390
作者:
Zhu, Huihui
;
Pu, Debing
;
Di, Qianqian
;
Zhao, Xibao
;
Ji, Feiyang
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2018/07/16
Cirsitakaoside
Lps
Inflammation
Macrophage
Nf-kappa b
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