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期刊论文 [18]
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Rational drug design of benzothiazole-based derivatives as potent signal transducer and activator of transcription 3 (STAT3) signaling pathway inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 216, 页码: 20
作者:
Gao, Dingding
;
Jin, Nan
;
Fu, Yixian
;
Zhu, Yueyue
;
Wang, Yujie
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2021/06/11
STAT3 signaling pathway
Benzothiazole
Rational design
Antitumor activity
Molecular docking
Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC
期刊论文
JOURNAL OF CANCER, 2020, 卷号: 11, 期号: 1, 页码: 241-250
作者:
Zhang, Yan
;
Yang, Xinying
;
Liu, Hongchun
;
Cai, Minghui
;
Yang Shentu
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
EGFR-TKIs
NSCLC
lymphangiogenesis
JAK/STAT3
LYVE-1
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2019, 卷号: 316, 期号: 3
作者:
Zhang, Jie
;
Wang, Dan
;
Wang, Lei
;
Wang, Shaohua
;
Roden, Anja C.
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  |  
浏览/下载:24/0
  |  
提交时间:2019/12/05
human lung fibroblast
IL-17A
IL-17RA
IPF
JAK inhibitors
NF-kappa B
RA-ILD
rheumatoid arthritis
STAT3
Pro-fibrotic effects of IL-17A and elevated IL-17RA in IPF and RA-ILD support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease
期刊论文
American journal of physiology. Lung cellular and molecular physiology, 2019
作者:
Zhang Jie[1]
;
Wang Dan[2]
;
Wang Lei[3]
;
Wang Shaohua[4]
;
Roden Anja C[5]
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2019/04/22
Human Lung Fibroblast
IL-17A IL-17RA
IPF RA-ILD
JAK Inhibitors STAT3
NF-кB Rheumatoid Arthritis
Profibrotic effect of IL-17A and elevated IL-17RA in idiopathic pulmonary fibrosis and rheumatoid arthritis-associated lung disease support a direct role for IL-17A/IL-17RA in human fibrotic interstitial lung disease
期刊论文
American journal of physiology. Lung cellular and molecular physiology, 2019, 卷号: 316, 页码: L487-L497
作者:
Zhang Jie[1]
;
Wang Dan[2]
;
Wang Lei[3]
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2019/04/22
IL-17A
IL-17RA
IPF
JAK inhibitors
NF-κB
RA-ILD
STAT3
human lung fibroblast
rheumatoid arthritis
3deoxy216dihydroxynagilactoneeanaturalcompoundfrompodocarpusnagipreferentiallyinhibitsjak2stat3signalingbyallostericallyinteractingwiththeregulatorydomainofjak2andinducesapoptosisofcancercells
期刊论文
actapharmacologicasinica, 2019, 卷号: 40, 期号: 12, 页码: 1578
作者:
Shan Hui
;
Yao Sheng
;
Ye Yang
;
Yu Qiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2β
16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
3-Deoxy-2β,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/ STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
中国药理学报:英文版, 2019, 卷号: 40.0, 期号: 012, 页码: 1578
作者:
Hui Shan
;
Sheng Yao
;
Yang Ye
;
Qiang Yu
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/12/24
JAK/STAT
3-deoxy-2β,16-dihydroxynagilactone
E
tyrosine
kinase
inhibitor
allosteric
inhibitor
cancer
A new xanthatin analogue 1 beta-hydroxyl-5 alpha-chloro-8-epi-xanthatin induces apoptosis through ROS-mediated ERK/p38 MAPK activation and JAK2/STAT3 inhibition in human hepatocellular carcinoma
期刊论文
BIOCHIMIE, 2018, 卷号: 152, 期号: 2018, 页码: 43-52
作者:
Fang, Xin-Yi
;
Zhang, Hai
;
Zhao, Lin
;
Tan, Shuai
;
Ren, Qing-Cuo
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/12/24
1 beta-hydroxyl-5 alpha-chloro-8-epi-xanthatin
Hepatocellular carcinoma
Apoptosis
Reactive oxygen species
Glutathione
MAPKs and JAK2/STAT3 cascades
Feedback Activation of Leukemia Inhibitory Factor Receptor Limits Response to Histone Deacetylase Inhibitors in Breast Cancer
期刊论文
CANCER CELL, 2016, 卷号: 30, 期号: 3, 页码: 459-473
作者:
Zeng, Hanlin
;
Qu, Jia
;
Jin, Nan
;
Xu, Jun
;
Lin, Chenchu
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
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