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CORC

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The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
Magnolol and honokiol regulate the calcium-activated potassium channels signaling pathway in Enterotoxigenic Escherichia coli-induced diarrhea mice 期刊论文
European Journal of Pharmacology, 2015, 卷号: 755, 页码: 66-73
作者:  Deng, Yanli;  Han, Xuefeng;  Tang, Shaoxun;  Xiao, Wenjun*;  Tan, Zhiliang
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/23
An allosteric model of the inositol trisphosphate receptor with nonequilibrium binding 其他
2014-01-01
Jia, Chen; Jiang, Daquan; Qian, Minping
收藏  |  浏览/下载：2/0  |  提交时间：2015/11/10
应用免疫算法研究肌醇1,4,5-磷酸三酯受体通道模型参数分布特性 期刊论文
2013
蔡秀红; 魏芳; 陈剑勇; 董斯瑜; 帅建伟
收藏  |  浏览/下载：5/0  |  提交时间：2016/05/17
Termination of Ca2+ Release for Clustered IP3R Channels 期刊论文
2012
Ruediger, Sten; Jung, Peter; Shuai, Jian-Wei; 帅建伟
收藏  |  浏览/下载：5/0  |  提交时间：2013/04/03
Calcium Domains around Single and Clustered IP3 Receptors and Their Modulation by Buffers 期刊论文
http://dx.doi.org/10.1016/j.bpj.2010.02.059, 2010
Rudiger, S.; Nagaiah, C.; Warnecke, G.; Shuai, J. W.; 帅建伟
收藏  |  浏览/下载：4/0  |  提交时间：2013/12/12
An investigation of models of the IP3R channel in Xenopus oocyte 期刊论文
http://dx.doi.org/10.1063/1.3156402, 2009
Shuai, J. W.; Yang, D. P.; Pearson, J. E.; Rudiger, S.; 帅建伟
收藏  |  浏览/下载：4/0  |  提交时间：2013/12/12
A General Analysis of Single IP_3 Receptors Modulated by Cytosolic Ca~(2+) and IP_3 其他
2009-01-01
Chen Jia; Yihan Li; Minping Qian
收藏  |  浏览/下载：2/0  |  提交时间：2017/12/03
Modeling Ca2+ feedback on a single inositol 1,4,5-trisphosphate receptor and its modulation by Ca2+ buffers 期刊论文
2008
Shuai, Jianwei; 帅建伟; Pearson, John E.; Parker, Ian
收藏  |  浏览/下载：3/0  |  提交时间：2011/07/16
Mode switching is the major mechanism of ligand regulation of InsP(3) receptor calcium release channels 期刊论文
2007
Ionescu, L; White, C; Cheung, KH; Shuai, J; Parker, I; Pearson, JE; Foskett, JK; Mak, DOD; 帅建伟
收藏  |  浏览/下载：2/0  |  提交时间：2013/12/12

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