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上海药物研究所 [8]
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期刊论文 [36]
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浏览/检索结果:
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E3 ubiquitin ligase NEDD4L negatively regulates inflammation by promoting ubiquitination of MEKK2
期刊论文
EMBO REPORTS, 2022
作者:
Li, Hui
;
Wang, Ning
;
Jiang, Yu
;
Wang, Haofei
;
Xin, Zengfeng
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2022/12/22
IL-17R signaling
inflammation
MEKK2
NEDD4L
ubiquitination
FPS-ZM1 inhibits LPS-induced microglial inflammation by suppressing JAK/STAT signaling pathway
期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2021, 卷号: 100, 页码: 12
作者:
Wang, Lan
;
Zhao, Danfeng
;
Wang, Huan
;
Wang, Lele
;
Liu, Xiaohui
收藏
  |  
浏览/下载:64/0
  |  
提交时间:2021/12/01
Inflammation
Microglia
LPS
RNA-seq
JAK
STAT signaling pathway
Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation
期刊论文
PSYCHONEUROENDOCRINOLOGY, 2020, 卷号: 113, 页码: 10
作者:
Zhang, Juntao
;
Lin, Wenjuan
;
Tang, Mingming
;
Zhao, Yawei
;
Zhang, Ke
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/05/18
Neuroinflammation
Depressive-like behavior
JNK
Proinflammatory cytokines
Glucocorticoid receptor
Anthocyanins from Lycium ruthenicum Murr. Ameliorated D-Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2019, 卷号: 67, 期号: 11
作者:
Chen, Shasha
;
Zhou, Haonan
;
Zhang, Gong
;
Meng, Jing
;
Deng, Kai
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2019/11/26
Lycium ruthenicum Murr
anthocyanins
oxidative stress
memory impairment
neuroinflammation
neurodegeneration
Xinjiang herbal tea exerts immunomodulatory activity via TLR2/4-mediated MAPK signaling pathways in RAW264.7 cells and prevents cyclophosphamide-induced immunosuppression in mice
期刊论文
JOURNAL OF ETHNOPHARMACOLOGY, 2019, 卷号: 228, 页码: 179-187
作者:
Bai, Yujia
;
Jiang, Yunyao
;
Liu, Tingwu
;
Li, Fu
;
Zhang, Jianmei
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  |  
浏览/下载:40/0
  |  
提交时间:2021/11/10
Xinjiang herbal tea
Immunomodulatory effect
Toll-like receptor
Nuclear factor-kappa B
Parthenolide Inhibits STAT3 Signaling by Covalently Targeting Janus Kinases
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 6
作者:
Liu, Man
;
Xiao, Chengqian
;
Sun, Mingwei
;
Tan, Minjia
;
Hu, Lihong
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2019/01/08
parthenolide
covalent inhibitor
cell death
JAK/STAT3 signaling
Pulmonary Exposure to Particulate Matter (PM2.5) Affects the Sensitivity to Myocardial Ischemia/Reperfusion Injury Through Farnesoid-X-Receptor-Induced Autophagy
期刊论文
Cellular Physiology & Biochemistry, 2018, 卷号: 46, 期号: 4, 页码: 1493-1507
作者:
Fei Tong;Hua Zhang
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  |  
浏览/下载:62/0
  |  
提交时间:2019/05/17
Pm2.5
lung Reperfusion
mi/ri
fxr
autophagy
Broad targeting of triptolide to resistance and sensitization for cancer therapy
期刊论文
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2018, 卷号: 104, 页码: 771-780
作者:
Hou, Zhen-yan
;
Tong, Xiao-pei
;
Peng, Yong-bo
;
Zhang, Bi-Kui*
;
Yan, Miao*
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  |  
浏览/下载:50/0
  |  
提交时间:2019/12/03
ABC
ATP-binding cassette
AKT
V-Akt murine thymoma viral oncogene homolog
ALDH1
aldehyde dehydrogenase 1
AR
androgen receptor
Bad
Bcl-2-associated death promoter
Bak
Bcl-2 homologous antagonist killer
Bax
Bcl-2-associated X protein
Bcl-2
B-cell lymphoma
Bcl-xL
Bcl-extra large
Bcl-xs
Bcl-extra short
BCRP
breast cancer resistance protein
Bid
BH3 interacting domain death agonist
Bik
Bcl-2-interacting killer
BNIP3
Bcl2/adenovirus E1B 19 kDa protein-interacting protein 3
CAF
cancer-associated fibroblast
CAIX
carbonic anhydrase IX
cFLIP
cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein
ChIP
chromatin immunoprecipitation
CI
Combination Index
cIAP1/2
cellular IAP1/2
CML
chronic myelogenous leukemia
CSC
cancer stem cell
DISC
death-inducing signaling complex
DR
death receptor
DRI
Dose Reduction Index
ECM
extracellular matrix
EMT
epithelial-mesenchymal transition
EpCAM
epithelial cell adhesion molecule
GLUT
glucose transporter
GSK3β
glycogen synthase kinase-3β
HIF-1
hypoxia inducible factor-1
HSF1
heat shock factor 1
HSP
heat shock protein
IAP
inhibitor of apoptosis protein
JNK
c-JUN N-terminal kinase
MAPK
mitogen-activated protein kinase
Mcl-1
myeloid leukemia cell differentiation protein
MDM2
murine double minute 2
MDR
multidrug resistance
MKP
MAPK phosphatase
MRP1
multidrug resistance protein 1
NF-κB
nuclear factor-kappaB
pAkt
phosphor-Akt
PARP
poly ADP-ribose polymerase
P-gp
P-glycoprotein
PI3K-PTEN
phosphatidylinositol 3-kinase-phosphatase and tensin homolog
PKC
phosphorylated at Ser9 by protein kinase C
pp2A
protein phosphatase 2A
REST
repressor element-1 silencing transcription factor
SAR
structure-activity relationship
TAM
tumor-associated macrophage
TFIIH
transcription factor IIH
TKI
tyrosine kinase inhibitor
TM
tumor-microenvironment
TRAIL/Apo-2L
TNF-related apoptosis-inducing ligand
tRXRα
the N-terminal truncated form of the nuclear retinoid X receptor-α
TWHF
Tripterygium wilfordii Hook F
VEGF
vascular endothelial growth factor
XIAP
X-linked IAP
XPB
xerodermapigmentosum group B protein
Triptolide
Antineoplastic
Resistance
Sensitization
Mechanism
Neurotensin/IL-8 pathway orchestrates local inflammatory response and tumor invasion by inducing M2 polarization of Tumor-Associated macrophages and epithelial-mesenchymal transition of hepatocellular carcinoma cells
期刊论文
ONCOIMMUNOLOGY, 2018, 卷号: 7, 期号: 7, 页码: 19
作者:
Xiao, Pei
;
Long, Xinxin
;
Zhang, Lijie
;
Ye, Yingnan
;
Guo, Jincheng
收藏
  |  
浏览/下载:41/0
  |  
提交时间:2019/12/10
Neurotensin
interleukin-8
hepatocellular carcinoma
epithelial-mesenchymal transition
tumor-associated macrophages
Dermatomyositis, polymyositis and immune-mediated necrotising myopathies
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015, 卷号: 1852, 期号: 4, 页码: 622-632
作者:
Luo, Yue-Bei
;
Mastaglia, Frank L
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/03
BAFF
B cell-activating factor
BLTK
B lymphoid tyrosine kinase
CCL21
chemokine (C-C motif) ligand 2
CK
creatine kinase
DC
dendritic cell
CTD
connective tissue disease
DFS70
dense fine speckled 70
DM
dermatomyositis
HIV
human immunodeficiency virus
HLA
human leukocyte antigen
HMGCR
3-hydroxy-3-methyl-glutaryl-CoA reductase
HTLV-1
human T cell leukaemia virus
IBM
inclusion body myositis
IFIH1
interferon induced with helicase C domain protein 1
IL
interleukin
IMNM
immune-mediated necrotising myopathies
INF
interferon
IP-10
INFγ-inducible 10-kD protein
ISG15
IFN-stimulated gene 15
I-TAC
IFN-inducible T cell α chemoattractant
LEDGF
lens epithelium-derived growth factor
MAC
membrane attack complex
MCP-1
monocyte chemoattractant protein-1
MCTD
mixed connective tissue disease
MDA5
melanoma differentiation-associated gene 5
MHC
major histocompatibility complex
MIF
macrophage inhibition factor
MIP-1α
macrophage inflammatory protein 1α
miRNA
microRNA
MxA
myxovirus resistance 1 protein
NuRD
nucleosome remodelling deacetylase complex
NXP-2
nuclear matrix protein 2
pDC
plasmacytoid dendritic cell
PKCε
protein kinase C ε type
PLCL1
phospholipase C like-1
PM
polymyositis
PTPN
protein tyrosine phosphatase N22 gene
SRP
signal recognition particle
RNP
ribonuclear protein complex
TIF
transcription intermediary factor
TLR
Toll like receptor
TNF
tumour necrosis factor
VCAM1
vascular cell adhesion molecule 1
VEGF
vascular endothelial growth factor
Idiopathic inflammatory myopathy
Polymyositis
Dermatomyositis
Immune-mediated necrotising myopathy
Autoantibody
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