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Characterization of the metabolites of tirabrutinib generated from rat, dog and human liver microsomes using ultra-high-performance liquid chromatography combined with high-resolution mass spectrometry
期刊论文
RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2022, 卷号: 36
作者:
Zhang, Hongjian
;
Hu, Zhen
;
Zhang, Huiping
;
Sun, Xiyan
;
Yang, Jianming
收藏
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浏览/下载:44/0
  |  
提交时间:2022/03/28
An Integrated Strategy to Identify and Quantify the Quality Markers of Xinkeshu Tablets Based on Spectrum-Effect Relationship, Network Pharmacology, Plasma Pharmacochemistry, and Pharmacodynamics of Zebrafish
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13
作者:
Wei, YH
;
Nie, L
;
Gao, LL
;
Zhong, L
;
Sun, ZY
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  |  
浏览/下载:20/0
  |  
提交时间:2022/12/02
Site-specific protein modification by 3-n-butylphthalide in primary hepatocytes: Covalent protein adducts diminished by glutathione and N-acetylcysteine
期刊论文
LIFE SCIENCES, 2021, 卷号: 287, 页码: 14
作者:
Xue, Yaru
;
Ren, Xuelian
;
Zhu, Zhengdan
;
Lei, Peng
;
Liu, Mengling
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2022/01/18
3-n-butylphthalide
Hepatotoxicity
Oxidative stresses
Covalent protein modification
Drug-drug interaction
Spectrum-effect relationship between UPLC fingerprints and antidiabetic and antioxidant activities of Rosa rugosa
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1179, 期号: 8, 页码: 1-9
作者:
Nijat, D (Nijat, Dilaram) 1 , 2
;
Lu, CF (Lu, Chun-fang) 1
;
Lu, JJ (Lu, Juan-juan) 1
;
Abdulla, R (Abdulla, Rahima) 1
;
Hasan, A (Hasan, Aobulikasimu) 1
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浏览/下载:51/0
  |  
提交时间:2021/09/22
Rosa rugosa
Spectrum-effectrelationship
Chemometricmethods
Qualitycontrol
An UHPLC-TOF-MS method for quantifying novel brominated anticancer compound bromophenol-thiosemicarbazone hybrid and its application to in vivo pharmacokinetic study
期刊论文
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY, 2020, 卷号: 11, 期号: 1, 页码: 7
作者:
Li, Xiuxue
;
Wang, Lijun
;
Jia, Xiaoling
;
Guo, Chuanlong
;
Li, Chao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2020/09/23
Novel compound
Quantitation
UHPLC-TOF-MS
Pharmacokinetics
Metabolomics reveals metabolite changes of patients with pulmonary arterial hypertension in China
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2020, 页码: 13
作者:
Chen, Chenyang
;
Luo, Fei
;
Wu, Panyun
;
Huang, Yiyuan
;
Das, Avash
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浏览/下载:34/0
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提交时间:2020/03/18
lipid metabolism
metabolomics
pulmonary arterial hypertension
The characterization of column heating effect in nanoflow liquid chromatography mass spectrometry (nanoLC-MS)-based proteomics
期刊论文
JOURNAL OF MASS SPECTROMETRY, 2020, 卷号: 55, 期号: 1, 页码: 10
作者:
Li, Bolin
;
Guo, Fang
;
Hu, Hao
;
Liu, Ping
;
Tan, Minjia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/07/01
column heating
hydrophilic
hydrophobic
nanoflow liquid chromatography
mass spectrometry
proteomics
Optimization of microwave-assisted extraction using response surface methodology and the potential anti-diabetic efficacy of Nigella glandulifera Freyn determined using the spectrum-effect relationship
期刊论文
INDUSTRIAL CROPS AND PRODUCTS, 2020, 卷号: 153, 期号: 10, 页码: 1-10
作者:
Ma, Y (Ma, Ye)[ 1,2 ]
;
Li, J (Li, Jun)[ 1 ]
;
Tong, F (Tong, Fei)[ 1 ]
;
Xin, XL (Xin, Xue-Lei)[ 1 ]
;
Aisa, HA (Aisa, Haji Akber)[ 1 ]
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2020/07/06
Nigella glandulifera Freyn
Microwave-assisted extraction
Response surface methodology
Aldose reductase inhibition
Spectrum-effect relationship
A high-efficiency strategy integrating offline two-dimensional separation and data post-processing with dereplication: Characterization of bufadienolides in Venenum Bufonis as a case study
期刊论文
JOURNAL OF CHROMATOGRAPHY A, 2019, 卷号: 1603, 页码: 179-189
作者:
Wei, Wenlong
;
Hou, Jinjun
;
Yao, Changliang
;
Bi, Qirui
;
Wang, Xia
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Offline two-dimensional liquid
chromatography
GNPS
High-efficiency
Dereplication
Bufadienolides of Venenum Bufonis
Characterization of TPN171 metabolism in humans via ultra-performance liquid chromatography/quadrupole time-of-flight Checir for mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2019, 卷号: 172, 页码: 302-310
作者:
Pan, Lulu
;
Guo, Shuang
;
Chen, Xiaoyan
;
Jiang, Xiangrui
;
Shen, Jingshan
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2020/07/01
TPNI71
Metabolism
UPLC/Q-TOF MS
High-resolution mass spectrometry
Metabolite identification
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