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上海药物研究所 [7]
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期刊论文 [22]
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Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model
期刊论文
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 3, 2020, 卷号: 320, 页码: G272-G282
作者:
Li W(李旺)
;
Li PW(李培文)
;
Li N(李宁)
;
Du Y(杜宇)
;
Lv SQ(吕守芹)
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2022/10/25
hepatocytes
liver fibrosis
matrix stiffness
shear flow
three-dimensional liver sinusoidal model
18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1865-1873
作者:
Wu, Shou-Yan
;
Cui, Shi-Chao
;
Wang, Le
;
Zhang, Yi-Ting
;
Yan, Xiao-Xia
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2019/01/08
18 beta-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 12, 页码: 1865-1873
作者:
Wu, Shou-yan
;
Cui, Shi-chao
;
Wang, Le
;
Zhang, Yi-ying
;
Yan, Xiao-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
hepatoprotective effect
cholestatic liver injury
18 beta-glycyrrhetinic acid (18b-GA)
FXR
Sirt1
bile acid transporters
The HNF1 alpha-regulated lncRNA HNF1A-AS1 reverses the malignancy of hepatocellular carcinoma by enhancing the phosphatase activity of SHP-1
期刊论文
MOLECULAR CANCER, 2018, 卷号: 17
作者:
Ding, Chen-Hong
;
Yin, Chuan
;
Chen, Shi-Jie
;
Wen, Liang-Zhi
;
Ding, Kai
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
HNF1 alpha
HNF1A-AS1
Hepatocellular carcinoma
SHP-1
phosphatase activity
18glycyrrhetinicacidprotectsagainstalphanaphthylisothiocyanateinducedcholestasisthroughactivationofthesirt1fxrsignalingpathway
期刊论文
中国药理学报英文版, 2018, 卷号: 039, 期号: 012, 页码: 1865
作者:
Shouyan Wu
;
Shichao Cui
;
Le Wang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
hepatoprotective
effect
cholestatic
liver
injury
18β-glycyrrhetinic
acid
(18b-GA)
FXR
Sirt1
bile
acid
transporters
18β-Glycyrrhetinic acid protects against alphanaphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway
期刊论文
Acta Pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1865
作者:
Wu Shouyan
;
Cui Shichao
;
Wang Le
;
Zhang Yiting
;
Yan Xiaoxia
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/12/24
hepatoprotective effect
cholestatic liver injury
18β-glycyrrhetinic acid (18b-GA)
FXR
Sirt1
bile acid transporters
Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription Factor
期刊论文
STEM CELL REPORTS, 2017, 卷号: 9, 期号: 2, 页码: 499-512
作者:
Guo, Ren
;
Tang, Wei
;
Yuan, Qianting
;
Hui, Lijian
;
Wang, Xin
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
Baicalin benefits the anti-HBV therapy via inhibiting HBV viral RNAs
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2017, 卷号: 323
作者:
Huang, Hai
;
Zhou, Wei
;
Zhu, Haiyan
;
Zhou, Pei
;
Shi, Xunlong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Baicalin
Anti-HBV
Nucleoside analog
HBV RNAs
Hepatocyte nuclear factors
Optimized Hepatocyte-Like Cells with Functional Drug Transporters Directly-Reprogrammed from Mouse Fibroblasts and their Potential in Drug Disposition and Toxicology
期刊论文
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2016, 卷号: 38, 期号: 5, 页码: 1815-1830
作者:
Wu, Zhi-Tao
;
Yao, Dan
;
Ji, Shu-Yi
;
Ni, Xuan
;
Gao, Yi-Meng
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/01/08
Direct reprogramming
Hepatocyte-like cells
Hepatic transporters
Biliary clearances
Cholestasis
Apolipoprotein M
期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2015, 卷号: 446, 页码: 21-29
作者:
Ren, Kun
;
Tang, Zhen-Li
;
Jiang, Yue
;
Tan, Yan-Mei
;
Yi, Guang-Hui*
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/27
apo
apolipoprotein
HDL
high-density lipoprotein
HNF-1α,4α
hepatocyte nuclear factor-1α,4α
LRH-1
liver receptor homolog-1
Foxa2
forkhead box A2
PAF
platelet activating factor
LXR
liver X receptor
RXR
retinoid X receptor
FXR
farnesoid X receptor
SHP
small heterodimer partner
S1P
Sphingosine-1-Phosphate
CVD
cardiovascular disease
HDL-C
HDL cholesterol
RCT
reverse cholesterol transport
MHC
major histocompatibility complex class III
TNF
tumor necrosis factor
HRP
haptoglobin-related protein
PON-I
paraoxonase-1
SNP
single nucleotide polymorphism
T1,2D
type 1,2 diabetes
RA
rheumatoid arthritis
ABCA1
ATP-binding cassette transporter A1
PPAR-γ
peroxisome proliferator-activated receptor γ
IL
interleukin
ABCG
ATP-binding cassette sub-family G
CETP
cholesteryl ester transfer protein
SR-B1
scavenger receptor class B member 1
MODY3
maturity-onset diabetes of the young type 3
MUP
major urinary protein
RBP
retinol binding protein
RAR
retinoic acid receptor
TR
thyroid hormone receptor
PI3K
phosphatidylinositol 3-kinase
DHC
dihydrocapsaicin
HRE
hormone response element
IGF-1
insulin-like growth factors
PAF-R
platelet activating factor receptor
TGF-α,β
transforming growth factor-α,β
EGF
epidermal growth factor
HGF
hepatic growth factor
VLDL
very low-density lipoprotein
LDL
low-density lipoprotein
ldlr
LDL receptor
ldlr−/−
LDL-receptor deficient
LCAT
lecithin-cholesterol acyltransferase
CE
cholesteryl ester
TC
total cholesterol
LDL-C
LDL cholesterol
VLDL-C
VLDL cholesterol
CHD
coronary heart disease
Mets
metabolic syndrome
S1PR
S1P receptor
NF-κB
nuclear factor-κB
NO
nitrogen oxide
eNOS
endothelial nitric oxide synthase
apoM-TgN mice
mice overexpressing human apoM by approximately two-fold
apoM-TgH mice
mice overexpressing human apoM by approximately ten-fold
apoM−/− mice
apoM-null mice
apoE−/−
apoE-null mice
Apolipoprotein M
Regulation
Function
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