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5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 19
作者:
Wang, Shuni
;
Yang, Hong
;
Su, Mingbo
;
Lian, Fulin
;
Cong, Zhanqing
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2021/11/04
NSD2
Methyltransferase
HTS
Multiple myeloma
5-Aminonaphthalene derivatives
Inhibitor
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 9, 页码: 10
作者:
Hou, Zeng
;
Min, Wenjian
;
Zhang, Rukang
;
Niu, Ao
;
Li, Yuanqing
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浏览/下载:45/0
  |  
提交时间:2020/07/01
Histone methylation
SET7
Small-molecule inhibitor
Virtual screening
Molecular probe
Loss of Gsdf leads to a dysregulation of Igf2bp3-mediated oocyte development in medaka
期刊论文
1st International Symposium of Chinese Comparative Endocrinologists (ISOCCE) held jointly with 12th Academic Conference of Chinese-Society-for-Comparative-Endocrinology, 2019, 卷号: 277, 期号: ,SI, 页码: 122-129
作者:
Wu, Xiaowen[1]
;
Zhang, Yingqing[2]
;
Xu, Shumei[3]
;
Chang, Yuyang[4]
;
Ye, Yang[5]
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  |  
浏览/下载:26/0
  |  
提交时间:2020/01/02
Gonadal soma-derived factor (Gsdf)
Insulin-like growth factor 2 mRNA binding protein 3 (Igf2bp3)
Trimethylated histone H3 lysine 27 (H3K27me3)
Identification of a cellularly active SIRT6 allosteric activator
期刊论文
NATURE CHEMICAL BIOLOGY, 2018, 卷号: 14, 期号: 12, 页码: 1118-+
作者:
Huang, Zhimin
;
Zhao, Junxing
;
Deng, Wei
;
Chen, Yingyi
;
Shang, Jialin
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浏览/下载:94/0
  |  
提交时间:2019/01/08
An Efficient Approach for Selective Enrichment of Histone Modification Readers Using Self-Assembled Multivalent Photoaffinity Peptide Probes
期刊论文
ANALYTICAL CHEMISTRY, 2018, 卷号: 90, 期号: 19, 页码: 11385-11392
作者:
Zhang, Kai
;
Zhai, Guijin
;
Dong, Hanyang
;
Guo, Zhenchang
;
Feng, Wei
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浏览/下载:50/0
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提交时间:2019/06/20
Identification and Characterizations of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Scaffold Hopping- and 2D-Molecular Fingerprint-Based Similarity Search
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 3
作者:
Ding, Hong
;
Lu, Wen Chao
;
Hu, Jun Chi
;
Liu, Yu-Chih
;
Zhang, Chen Hua
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浏览/下载:52/0
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提交时间:2019/01/08
SET7
inhibitor
similarity search
ligand-based drug design
chemical biology probe
Effects of adolescent social stress and antidepressant treatment on cognitive inflexibility and Bdnf epigenetic modifications in the mPFC of adult mice
期刊论文
PSYCHONEUROENDOCRINOLOGY, 2018, 卷号: 88, 页码: 92-101
作者:
Xu, Hang
;
Wang, Jiesi
;
Zhang, Ke
;
Zhao, Mei
;
Ellenbroek, Bart
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浏览/下载:42/0
  |  
提交时间:2018/05/28
Adolescent
Social stress
Cognitive inflexibility
Brain-derived neurotrophic factor (BDNF)
Epigenetic mechanism
Architecture and subunit arrangement of the complete Saccharomyces cerevisiae COMPASS complex
期刊论文
SCIENTIFIC REPORTS, 2018, 卷号: 8, 期号: 1, 页码: 17405
作者:
Wang, Yanxing
;
Ding, Zhanyu
;
Liu, Xiangyang
;
Bao, Yu
;
Huang, Min
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  |  
浏览/下载:67/0
  |  
提交时间:2019/04/28
Histone H3k4 Methylases
Set Domain
Methyltransferase Complex
Structural Basis
Lysine 4
Protein
Family
Ubiquitination
Termination
Recruits
Uncovering the mechanistic basis for specific recognition of monomethylated H3K4 by the CW domain of Arabidopsis histone methyltransferase SDG8
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 卷号: 293, 期号: 17, 页码: 6470-6481
作者:
Liu, Yanchao
;
Huang, Ying
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  |  
浏览/下载:27/0
  |  
提交时间:2019/04/28
Flowering Time Regulation
Gene-expression
Chromatin Modifications
Epigenetic Regulation
Containing Proteins
Structural Insight
Methylation
Transcription
Repression
Thaliana
Structural Analysis of the Arabidopsis AL2-PAL and PRC1 Complex Provides Mechanistic Insight into Active-to-Repressive Chromatin State Switch
期刊论文
JOURNAL OF MOLECULAR BIOLOGY, 2018, 卷号: 430, 期号: 21, 页码: 4245-4259
作者:
Peng, Ling
;
Wang, Longlong
;
Zhang, Yingpei
;
Huang, Ying
;
Dong, Aiwu
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  |  
浏览/下载:50/0
  |  
提交时间:2019/04/28
Stem-cells
H2a Ubiquitylation
Targeting Polycomb
Gene
Recruitment
Expression
Drosophila
Trimethylation
Thaliana
H3k27me3
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