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Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
收藏
  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
Furmonertinib (Alflutinib, AST2818) is a potential positive control drug comparable to rifampin for evaluation of CYP3A4 induction in sandwich-cultured primary human hepatocytes
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 10
作者:
Wu, Ya-li
;
Xue, Ya-ru
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Ge, Xin-yu
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  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
furmonertinib (alflutinib
AST2818)
quantitative proteomics
sandwich-cultured human hepatocytes
Pharmacokinetic Drug-drug Interaction of Antibiotics Used in Sepsis Care in China
期刊论文
CURRENT DRUG METABOLISM, 2021, 卷号: 22, 期号: 1, 页码: 5-23
作者:
Yu, Xuan
;
Chu, Zixuan
;
Li, Jian
;
He, Rongrong
;
Wang, Yaya
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
Pharmacokinetics
drug-drug interaction
antibiotic
sepsis
transporter
enzyme
Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Liu, Xiao-yun
;
Guo, Zi-tao
;
Chen, Zhen-dong
;
Zhang, Yi-fan
;
Zhou, Jia-lan
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  |  
浏览/下载:80/0
  |  
提交时间:2020/07/01
alflutinib
AST5902
metabolism
enzyme induction
drug-drug interaction
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:48/0
  |  
提交时间:2020/07/01
Cytochrome P450 3A Enzymes Are Key Contributors for Hepatic Metabolism of Bufotalin, a Natural Constitute in Chinese Medicine Chansu
期刊论文
FRONTIERS IN PHARMACOLOGY, 2019, 卷号: 10, 页码: 10
作者:
Ma, Hong-Ping
;
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
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  |  
浏览/下载:67/0
  |  
提交时间:2019/06/20
bufotalin
cytochrome P450 3A (CYP3A)
hydroxylation
human liver microsomes (HLMs)
docking simulations
Cytochrome p450 3a enzymes are key contributors for hepatic metabolism of bufotalin, a natural constitute in chinese medicine chansu
期刊论文
Frontiers in pharmacology, 2019, 卷号: 10, 页码: 10
作者:
Dai, Zi-Ru
;
Ning, Jing
;
Sun, Gui-Bo
;
Wang, Ping
;
Zhang, Feng
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  |  
浏览/下载:90/0
  |  
提交时间:2019/05/08
Bufotalin
Cytochrome p450 3a (cyp3a)
Hydroxylation
Human liver microsomes (hlms)
Docking simulations
Effects on Expression of Hepatic Phase-1 and Phase-2 Metabolism and Transporter Genes by Swertia mussotii Extract, A Hepatoprotective Herb from Tibetan Traditional Medicine
期刊论文
INTERNATIONAL JOURNAL OF AGRICULTURE AND BIOLOGY, 2019, 卷号: 21, 期号: 5
作者:
Yang, Hongxia
;
Xiao, Yuancan
;
Li, Cen
;
Gao, Tingting
;
Wei, Lixin
收藏
  |  
浏览/下载:57/0
  |  
提交时间:2019/11/26
Tibetan traditional medicine
Swertia mussotii
Cytochrome P450
Hepatic transporters
Differences in the In Vivo and In Vitro Metabolism of Imrecoxib in Humans: Formation of the Rate-Limiting Aldehyde Intermediate
期刊论文
DRUG METABOLISM AND DISPOSITION, 2018, 卷号: 46, 期号: 9, 页码: 1320-1328
作者:
Hou, Xiangyu
;
Zhou, Jialan
;
Yu, Songda
;
Zhou, Lei
;
Zhang, Yifan
收藏
  |  
浏览/下载:70/0
  |  
提交时间:2019/01/08
CYP3A4 inducer and inhibitor strongly affect the pharmacokinetics of triptolide and its derivative in rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 8, 页码: 1386-1392
作者:
Xu, Ye
;
Zhang, Yi-fan
;
Chen, Xiao-yan
;
Zhong, Da-fang
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  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
triptolide
(5R)-5-hydroxytriptolide
CYP3A4
ritonavir
dexamethasone
pharmacokinetics
immunosuppressant
traditional Chinese medicine
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