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Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists
期刊论文
PHARMACEUTICALS, 2022, 卷号: 15
作者:
Sun, Lei
;
Zheng, Zhi-Ming
;
Shao, Chang-Sheng
;
Zhang, Zhi-Yong
;
Li, Ming-Wei
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2022/12/22
glucagon-like peptide-1
GLP-1 receptor agonist
functional protein design
molecular dynamics simulation
long-acting antihyperglycemic
Bionic-immobilized recombinant lipase obtained via bio-silicification and its catalytic performance in biodiesel production
期刊论文
FUEL, 2021, 卷号: 304, 页码: 11
作者:
Zhang, Jun
;
Chen, Xiaoyan
;
Lv, Pengmei
;
Luo, Wen
;
Wang, Zhiyuan
收藏
  |  
浏览/下载:76/0
  |  
提交时间:2021/10/27
Lipase
Bionic-immobilization
Biodiesel
Bio-silicification
Molecular dynamics simulation
Exploring the Regulatory Function of the N-terminal Domain of SARS-CoV-2 Spike Protein through Molecular Dynamics Simulation
期刊论文
ADVANCED THEORY AND SIMULATIONS, 2021, 页码: 13
作者:
Li, Yao
;
Wang, Tong
;
Zhang, Juanrong
;
Shao, Bin
;
Gong, Haipeng
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  |  
浏览/下载:53/0
  |  
提交时间:2021/11/04
"wedge" effect
molecular dynamics simulations
N-terminal domain
SARS-CoV-2
Spike protein
Reexamining the role of intercrystalline links in the II-I phase transition of Poly(1-butene)
期刊论文
POLYMER, 2021, 卷号: 224
作者:
Li, Xiangyang
;
Chen, Pujing
;
Xu, Min
;
Ding, Jianjun
;
Zheng, Kang
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  |  
浏览/下载:72/0
  |  
提交时间:2021/06/15
Form II to form I phase transition
Intercrystalline links
poly(1-butene)
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:83/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
Natural product 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose is a reversible inhibitor of glyceraldehyde 3-phosphate dehydrogenase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 13
作者:
Li, Wen
;
Liao, Li-ping
;
Song, Ning
;
Liu, Yan-jun
;
Ding, Yi-luan
收藏
  |  
浏览/下载:82/0
  |  
提交时间:2021/06/11
glyceraldehyde 3-phosphate dehydrogenase
1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranose
hydrogen deuterium exchange mass spectrometry
reversible inhibitor
glycolysis
Insights into the molecular mechanism of positive cooperativity between partial agonist MK-8666 and full allosteric agonist AP8 of hGPR40 by Gaussian accelerated molecular dynamics (GaMD) simulations
期刊论文
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2021, 卷号: 19, 页码: 3978-3989
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Huanxiang
;
Yao, Xiaojun
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  |  
浏览/下载:13/0
  |  
提交时间:2021/12/08
hGPR40
Positive binding cooperativity
Partial agonist
AgoPAM
Gaussian accelerated molecular dynamics simulation
Distance makes a difference in crystalline photoluminescence
期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11
作者:
Gan, Zibao
;
Liu, Yungui
;
Wang, Lin
;
Jiang, Shuqing
;
Xia, Nan
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  |  
浏览/下载:23/0
  |  
提交时间:2020/12/28
Unveiling conformational dynamics changes of H-Ras induced by mutations based on accelerated molecular dynamics
期刊论文
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2020, 卷号: 22, 期号: 37, 页码: 21238-21250
作者:
Chen, Jianzhong
;
Wang, Wei
;
Pang, Laixue
;
Zhu, Weiliang
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2020/12/21
Blood-Brain Barrier Permeable Chitosan Oligosaccharides Interfere with beta-Amyloid Aggregation and Alleviate beta-Amyloid Protein Mediated Neurotoxicity and Neuroinflammation in a Dose- and Degree of Polymerization-Dependent Manner
期刊论文
MARINE DRUGS, 2020, 卷号: 18, 期号: 10, 页码: 22
作者:
Zhu, Limeng
;
Li, Ruilian
;
Jiao, Siming
;
Wei, Jinhua
;
Yan, Yalu
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2021/03/29
Alzheimer’
s disease
chitosan oligosaccharides
blood-brain barrier
Aβ
42
aggregation
binding affinity
cytotoxicity
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