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上海药物研究所 [34]
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Repressing MYC by targeting BET synergizes with selective inhibition of PI3K alpha against B cell lymphoma
期刊论文
CANCER LETTERS, 2022, 卷号: 524, 页码: 206-218
作者:
Chen, Zi-qi
;
Cao, Zhe-rui
;
Wang, Yi
;
Zhang, Xi
;
Xu, Lan
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2021/12/16
CYH33
MYC
P300
BET
B cell lymphoma
PI3K
Shabyar Ameliorates High Glucose Induced Retinal Pigment Epithelium Injury Through Suppressing Aldose Reductase and AMPK/mTOR/ULK1 Autophagy Pathway
期刊论文
FRONTIERS IN PHARMACOLOGY, 2022, 卷号: 13, 期号: 5, 页码: 1-15
作者:
Liu, XY (Liu, Xiao Yan) [1] , [2] , [3]
;
Peng, J (Peng, Jun) [1] , [2]
;
He, F (He, Fei) [1]
;
Tursun, X (Tursun, Xirali) [4]
;
Li, SP (Li, Shu Ping) [1]
收藏
  |  
浏览/下载:130/0
  |  
提交时间:2022/06/06
shabyar
retinal pigment epithelium
autophagy
aldose reductase
traditional medicine formula
Preclinical characterization of LOXO-338, a novel, oral and selective BCL2 inhibitor.
期刊论文
CANCER RESEARCH, 2021, 卷号: 81, 期号: 13, 页码: 1
作者:
Brandhuber, Barbara
;
Ku, Karin
;
Lallena, Maria J.
;
Baquero, Carmen
;
Choy, Regina
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  |  
浏览/下载:13/0
  |  
提交时间:2021/11/04
Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?
期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 卷号: 15
作者:
Yu, Qing
;
Sun, Yi
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  |  
浏览/下载:25/0
  |  
提交时间:2021/03/15
anti-cancer drug
cullin-RING E3 ligases
natural product
high-throughput screen
neddylation
small-molecule inhibitors
A pectin-like polysaccharide from Polygala tenuifolia inhibits pancreatic cancer cell growth in vitro and in vivo by inducing apoptosis and suppressing autophagy
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 162, 页码: 107-115
作者:
Bian, Youcheng
;
Zeng, Hui
;
Tao, Hong
;
Huang, Lulin
;
Du, Zhenyun
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/12/24
Polygala tenuifolia
Pectin
Pancreatic cancer
Apoptosis
Autophagy
Antispasmodic Drug Drofenine as an Inhibitor of Kv2.1 Channel Ameliorates Peripheral Neuropathy in Diabetic Mice
期刊论文
ISCIENCE, 2020, 卷号: 23, 期号: 10, 页码: 56
作者:
Xu, Xiaoju
;
Xu, Xu
;
Hao, Yanping
;
Zhu, Xialin
;
Lu, Jian
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/05/24
Downregulation of CDC20 Increases Radiosensitivity through Mcl-1/p-Chk1-Mediated DNA Damage and Apoptosis in Tumor Cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 卷号: 21
作者:
Gao, Yang
;
Wen, Pengbo
;
Chen, Bin
;
Hu, Guanshuo
;
Wu, Lijun
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/11/30
CDC20
radiotherapy
Mcl-1
p-Chk1
mitochondrial-dependent apoptotic pathway
BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib in vitro and in vivo by promoting mitochondrial pathway-mediated cell apoptosis
期刊论文
THERAPEUTIC ADVANCES IN HEMATOLOGY, 2020, 卷号: 11, 页码: 12
作者:
Li, Guang
;
Zheng, Yan-Hua
;
Xu, Li
;
Feng, Juan
;
Tang, Hai-Long
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/12/24
apoptosis
BRD4 inhibitor
G1 phase cell cycle checkpoint
multiple myeloma
Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 152, 页码: 52-60
作者:
Liu, Yunen
;
Tong, Changci
;
Tang, Yushan
;
Cong, Peifang
;
Liu, Ying
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/02/02
Blast injury
Tan IIA
Acute lung injury
Oxidative stress
Inflammation
PI3K
Akt
FoxO1 signaling pathway
Tanshinone IIA alleviates blast -induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway
期刊论文
FREE RADICAL BIOLOGY AND MEDICINE, 2020, 卷号: 152, 页码: 52-60
作者:
Liu, Yunen
;
Tong, Changci
;
Tang, Yushan
;
Cong, Peifang
;
Liu, Ying
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2021/02/02
Blast injury
Tan IIA
Acute lung injury
Oxidative stress
Inflammation
PI3K
Akt
FoxO1 signaling pathway
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