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Constitutive signal bias mediated by the human GHRHR splice variant 1
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 卷号: 118, 期号: 40, 页码: 10
作者:
Cong, Zhaotong
;
Zhou, Fulai
;
Zhang, Chao
;
Zou, Xinyu
;
Zhang, Huibing
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2021/12/01
class B1 GPCR
receptor bias
cancer
cell proliferation
甘丙肽对抑郁症状的调控作用及其机制的研究进展
期刊论文
生物化学与生物物理进展, 2021, 页码: 15
作者:
薛冰
;
马寅燕
;
梁璟
;
李勇辉
;
张建军
收藏
  |  
浏览/下载:39/0
  |  
提交时间:2021/12/03
甘丙肽
甘丙肽受体
抑郁
Mechanistic in silico modeling of bisphenols to predict estrogen and glucocorticoid disrupting potentials
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 卷号: 728, 页码: 1-11
作者:
Chen, Qinchang
;
Zhou, Chengzhuo
;
Shi, Wei
;
Wang, Xiaoxiang
;
Xia, Pu
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  |  
浏览/下载:22/0
  |  
提交时间:2021/09/14
Endocrine disruptor
Estrogen receptor
Glucocorticoid receptor
Coregulators
Accelerated molecular dynamics simulations
Binding free energy
In vitro estrogen-disrupting effects of organophosphate flame retardants
期刊论文
SCIENCE OF THE TOTAL ENVIRONMENT, 2020, 卷号: 727, 页码: 1-10
作者:
Ji, Xiaoya
;
Li, Na
;
Ma, Mei
;
Rao, Kaifeng
;
Wang, Zijian
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  |  
浏览/下载:25/0
  |  
提交时间:2021/09/15
OPFRs
Estrogen-disrupting effects
ER alpha
Yeast two-hybrid assay
MVLN cell assay
E-SCREEN assay
Molecular dynamics simulation revealed the intrinsic conformational change of cellular inhibitor of apoptosis protein-1
期刊论文
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 2020, 卷号: 38, 期号: 4, 页码: 975-984
作者:
Xu, Heng
;
Tang, Zhengkuan
;
Zuo, Yu
;
Xiong, Fengmin
;
Chen, Kaixian
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  |  
浏览/下载:47/0
  |  
提交时间:2020/07/01
cIAP1
dimerization
conformational change
MD simulation
Revealing the Positive Binding Cooperativity Mechanism between the Orthosteric and the Allosteric Antagonists of CCR2 by Metadynamics and Gaussian Accelerated Molecular Dynamics Simulations
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2020, 卷号: 11, 期号: 4, 页码: 628-637
作者:
An, Xiaoli
;
Bai, Qifeng
;
Bing, Zhitong
;
Liu, Hongli
;
Zhang, Qianqian
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  |  
浏览/下载:24/0
  |  
提交时间:2022/01/18
CC chemokine receptor 2
orthosteric antagonist
allosteric antagonist
binding cooperativity
metadynamics simulation
Gaussian accelerated MD simulation
Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2019, 卷号: 10, 期号: 8, 页码: 3622-3634
作者:
Wang, Xiaohui
;
Northcutt, Alexis L.
;
Cochran, Thomas A.
;
Zhang, Xiaozheng
;
Fabisiak, Timothy J.
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  |  
浏览/下载:88/0
  |  
提交时间:2019/09/30
A comparison of endocrine disruption potential of nonylphenol ethoxylate, vanillin ethoxylate, 4-n-nonylphenol and vanillin in vitro
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 175, 页码: 208-214
作者:
Ji, Xiaoya
;
Li, Na
;
Yuan, Shengwu
;
Zhou, Xiaohong
;
Ding, Fengmei
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2020/10/23
Nonylphenol ethoxylate
Vanillin ethoxylate
4-n-nonylphenol
Vanillin
Nuclear receptors
Two-hybrid yeast
Accelerating the Throughput of Affinity Mass Spectrometry-Based Ligand Screening toward a G Protein-Coupled Receptor
期刊论文
ANALYTICAL CHEMISTRY, 2019, 卷号: 91, 期号: 13, 页码: 8162-8169
作者:
Lu, Yan
;
Qin, Shanshan
;
Zhang, Bingjie
;
Dai, Antao
;
Cai, Xiaoqing
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2020/07/01
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3088-3106
作者:
Kong, Deyu
;
Xue, Tao
;
Guo, Bin
;
Cheng, Jianjun
;
Liu, Shunyin
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
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