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Picomolar antimalarial agent from a Chinese medicinal plant
期刊论文
SCIENCE CHINA-CHEMISTRY, 2021, 页码: 5
作者:
Zhou, Bin
;
Zimbres, Flavia M.
;
Butler, Joshua H.
;
Xu, Cheng-Hui
;
Haney, Reagan S.
收藏
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浏览/下载:62/0
  |  
提交时间:2021/12/01
medicinal plants
dimeric sesquiterpenoids
antimalarial agent
structure-activity relationship
Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439
期刊论文
ACS INFECTIOUS DISEASES, 2021, 卷号: 7, 期号: 7, 页码: 1885-1893
作者:
Shackleford, David M.
;
Chiu, Francis C. K.
;
Katneni, Kasiram
;
Blundell, Scott
;
McLaren, Jenna
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  |  
浏览/下载:59/0
  |  
提交时间:2021/11/04
OZ439 (artefenomel)
malaria
metabolite identification
cytochrome P450 metabolism
cytochrome P450 inhibition
time-dependent inhibition
In Vivo Efficacy and Metabolism of the Antimalarial Cycleanine and Improved In Vitro Antiplasmodial Activity of Semisynthetic Analogues
期刊论文
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2021, 卷号: 65, 期号: 2, 页码: 11
作者:
Uche, Fidelia Ijeoma
;
Guo, Xiaozhen
;
Okokon, Jude
;
Ullah, Imran
;
Horrocks, Paul
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浏览/下载:26/0
  |  
提交时间:2021/05/24
malaria
Plasmodium falciparum
Plasmodium berghei
bisbenzylisoquinoline alkaloids
cycleanine
metabolism
in vivo activity
antimalarial agents
drug metabolism
Pharmacophore-Based Virtual Screening Toward the Discovery of Novel Anti-echinococcal Compounds
期刊论文
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2020, 卷号: 10, 页码: 12
作者:
Liu, Congshan
;
Yin, Jianhai
;
Yao, Jiaqing
;
Xu, Zhijian
;
Tao, Yi
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  |  
浏览/下载:42/0
  |  
提交时间:2020/07/01
echinococcosis
Echinococcus multilocularis
pharmacophore modeling
virtual screenings
in vitro drug screen
cytotoxicity
E
multilocularis-infected mice
pharmacokinetics analysis
Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188
作者:
Liang, Xiaofei
;
Jiang, Zongru
;
Huang, Zhenghui
;
Li, Feng
;
Chen, Cheng
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浏览/下载:28/0
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提交时间:2020/11/26
PI4K kinase
Kinase inhibitor
Malaria
Blood stage
Liver stage
1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 16, 页码: 3511-3531
作者:
Bozorov, K (Bozorov, Khurshed)[ 1,2 ]
;
Zhao, JY (Zhao, Jiangyu)[ 1 ]
;
Aisa, HA (Aisa, Haji A.)[ 1 ]
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浏览/下载:51/0
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提交时间:2019/09/02
1,2,3-Triazole
Click chemistry
Copper-catalysed 1,3-dipolar cycloaddition (CuAAC)
Huisgen azide-alkyne cycloaddition
Biological activity
Lead compounds
Cipaferoids A-C, Three Limonoids Represent Two Different Scaffolds from Cipadessa baccifera
期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2018, 卷号: 36, 期号: 2, 页码: 124-128
作者:
Yu, Jinhai
;
Zhou, Bin
;
Dalal, Seema
;
Liu, Qunfang
;
Cassera, Maria B.
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
cipaferoids
Cipadessa baccifera
limonoids
structural elucidation
antimalarial activity
Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 143, 页码: 1139-1147
作者:
Spry, Christina
;
Sewell, Alan L.
;
Hering, Yuliya
;
Villa, Mathew V. J.
;
Weber, Jonas
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  |  
浏览/下载:3/0
  |  
提交时间:2019/11/26
Plasmodium falciparum
Pantothenate
Pantothenate kinase
Antimalarial
CJ-15,801
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