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科研机构
上海药物研究所 [3]
湖南中医药大学 [1]
内容类型
期刊论文 [4]
发表日期
2016 [1]
2012 [1]
2011 [1]
2003 [1]
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The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
中国健康志愿者单次和多次口服阿德福韦酯片的药动学
期刊论文
中国药学杂志, 2012, 卷号: 047, 期号: 019, 页码: 1570
作者:
奚培英
;
张云轩
;
施孝金
;
李中东
;
陈妙英
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2020/07/01
阿德福韦酯
阿德福韦
药动学
液相色谱-串联质谱法
Determination of Trimetazidine in Human Plasma by LC-MS/MS and Its Pharmacokinetic Study
期刊论文
China Pharmacy, 2011, 卷号: 22, 期号: 2, 页码: 143-145
作者:
Lv Jiang
;
Chen Xiaohui
;
Zhang Ruirui
;
Zhang Ming
;
Zhang Hong
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2019/01/08
Trimetazidine
LC-MS
Pharmacokinetics
Plasma concentration
The bioequivalence study of fluoxetine HCl capsule and its dispersible tablets in healthy volunteers
期刊论文
Chinese Journal New Drugs, 2003, 卷号: 12, 期号: 4, 页码: 277-281
作者:
Shao Qingxiang
;
Li Chuan
;
Zhang Meiyun
;
Ji Zhouhua
;
Liu Ping
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
fluxoetine HCl
dispersible tablet
LC/MS/MS
bioequivalence
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