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上海药物研究所 [28]
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浏览/检索结果:
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An App knock-in rat model for Alzheimer's disease exhibiting A beta and tau pathologies, neuronal death and cognitive impairments
期刊论文
CELL RESEARCH, 2021, 页码: 19
作者:
Pang, Keliang
;
Jiang, Richeng
;
Zhang, Wei
;
Yang, Zhengyi
;
Li, Lin-Lin
收藏
  |  
浏览/下载:127/0
  |  
提交时间:2021/12/27
An App knock-in rat model for Alzheimer's disease exhibiting A beta and tau pathologies, neuronal death and cognitive impairments
期刊论文
CELL RESEARCH, 2021, 页码: 19
作者:
Pang, Keliang
;
Jiang, Richeng
;
Zhang, Wei
;
Yang, Zhengyi
;
Li, Lin-Lin
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/12/28
Paper Dynamic changes in vascular size and density in transgenic mice with Alzheimer's disease
期刊论文
AGING-US, 2020, 卷号: 12
作者:
Xu, Xiaowen
;
Meng, Tong
;
Wen, Qingqing
;
Tao, Mengling
;
Wang, Peijun
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/11/30
Alzheimer's disease
hippocampus
magnetic resonance imaging
vessel size imaging
early diagnosis
Yeast-Based A beta 1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice
期刊论文
VACCINES, 2020, 卷号: 8, 期号: 3, 页码: 13
作者:
Liu, Dong-qun
;
Lu, Shuai
;
Zhang, Lun
;
Huang, Ya-ru
;
Ji, Mei
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/03/29
Alzheimer's disease
beta-amyloid
active immunotherapy
yeast
vaccine
Discovery of nitazoxanide-based derivatives as autophagy activators for the treatment of Alzheimer's disease
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 4, 页码: 646-666
作者:
Li, Xiaokang
;
Lu, Jian
;
Xu, Yixiang
;
Wang, Jiaying
;
Qiu, Xiaoxia
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Alzheimer's disease
Autophagy
Nitazoxanide
beta-amyloid
Tau protein
Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 144, 页码: 1004-1012
作者:
Zhou, Yue
;
Duan, Yanhong
;
Huang, Shichao
;
Zhou, Xuan
;
Zhou, Lishuang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2020/07/01
Lycium barbarum polysaccharides
Alzheimer's disease
Amyloid-beta
Synaptic plasticity
Neuropathology
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291
作者:
Fan, Lei
;
Qiu, Xiao-xia
;
Zhu, Zhi-yuan
;
Lv, Jian-lu
;
Lu, Jian
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Alzheimer's disease
nitazoxanide
autophagy
inflammation
APP/PS1 transgenic mice
Inhibition of sphingomyelin synthase 1 ameliorates alzheimer-like pathology in APP/PS1 transgenic mice through promoting lysosomal degradation of BACE1
期刊论文
EXPERIMENTAL NEUROLOGY, 2019, 卷号: 311
作者:
Lu, Mei-Hong
;
Ji, Wen-Li
;
Xu, De-En
;
Yao, Pei-Pei
;
Zhao, Xiu-Yun
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/04
BACE1
Sphingomyelin
Amyloid-beta
Lysosomal degradation
Alzheimer's disease
Lipids
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