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科研机构
北京大学 [10]
上海药物研究所 [10]
中国医学科学院 北京... [9]
山东大学 [8]
武汉物理与数学研究所 [5]
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期刊论文 [77]
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DW14006 as a direct AMPK alpha 1 activator improves pathology of AD model mice by regulating microglial phagocytosis and neuroinflammation
期刊论文
BRAIN BEHAVIOR AND IMMUNITY, 2020, 卷号: 90, 页码: 55-69
作者:
Lv, Jianlu
;
Wang, Wei
;
Zhu, Xialin
;
Xu, Xiaoju
;
Yan, Qiuying
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/12/21
Alzheimer'sdisease
Microglia
AMPK alpha 1
DW14006
Phagocytosis
Neuro-inflammation
Vaccines targeting the primary amino acid sequence and conformational epitope of amyloid-beta had distinct effects on neuropathology and cognitive deficits in EAE/AD mice
期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2020, 页码: 12
作者:
Yu, Xiao-Lin
;
Zhu, Jie
;
Liu, Xiang-meng
;
Xu, Peng-xin
;
Zhang, Yue
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2020/05/21
Polysaccharides from Lycium barbarum ameliorate amyloid pathology and cognitive functions in APP/PS1 transgenic mice
期刊论文
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 卷号: 144, 页码: 1004-1012
作者:
Zhou, Yue
;
Duan, Yanhong
;
Huang, Shichao
;
Zhou, Xuan
;
Zhou, Lishuang
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2020/07/01
Lycium barbarum polysaccharides
Alzheimer's disease
Amyloid-beta
Synaptic plasticity
Neuropathology
High-resolution mapping of brain vasculature and its impairment in the hippocampus of Alzheimer's disease mice
期刊论文
NATIONAL SCIENCE REVIEW, 2019, 卷号: 6, 期号: 6, 页码: 1223-1238
作者:
Zhang, Xiaochuan
;
Yin, Xianzhen
;
Zhang, Jingjing
;
Li, Anan
;
Gong, Hui
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2020/07/01
Micro-Optical Sectioning Tomography
image optimization
Alzheimer's disease
impaired hippocampal vasculature
virtual vascular endoscopy
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis
期刊论文
Antioxidants & Redox Signaling, 2019, 卷号: Vol.30 No.11, 页码: 1411-1431
作者:
Chun-Yan Wang
;
Ye Xu
;
Xu Wang
;
Chuang Guo
;
Tao Wang
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/13
Alzheimer's disease
APP/PS1 transgenic mouse
Nrf2-TXNIP-TrX axis
Dl-NBP
NLRP3 inflammasome
Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease
期刊论文
The Anatomical Record, 2019, 卷号: Vol.302 No.2, 页码: 332-338
作者:
Wei‐Tian Lu
;
Shan‐Quan Sun
;
Yu Li
;
Shi‐Ye Xu
;
Sheng‐Wei Gan
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/17
Alzheimer's
disease
monocarboxylate
transporter
lactate
long‐term
memory
curcumin
Altered mitochondrial DNA methylation and mitochondrial DNA copy number in an APP/PS1 transgenic mouse model of Alzheimer disease
期刊论文
Biochemical and Biophysical Research Communications, 2019, 卷号: 520, 期号: 1, 页码: 41-46
作者:
Xu Y.
;
Xu L.
;
Han M.
;
Liu X.
;
Li F.
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/11
12S rRNA gene
Alzheimer's disease
APP/PS1 transgenic mice
D-loop
Mitochondrial DNA copy number
Mitochondrial DNA methylation
Curcumin Ameliorates Memory Deficits by Enhancing Lactate Content and MCT2 Expression in APP/PS1 Transgenic Mouse Model of Alzheimer's Disease
期刊论文
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 2019, 卷号: Vol.302 No.2, 页码: 332-338
作者:
Lu, Wei-Tian
;
Sun, Shan-Quan
;
Li, Yu
;
Xu, Shi-Ye
;
Gan, Sheng-Wei
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/17
Alzheimer's disease
monocarboxylate transporter
lactate
long-term memory
curcumin
Rapamycin regulates cholesterol biosynthesis and cytoplasmic ribosomal proteins in hippocampus and temporal lobe of APP/PS1 mouse
期刊论文
2019, 卷号: 399, 页码: 125-139
作者:
Wang, Xia
;
Xia, Wenchao
;
Li, Kai
;
Zhang, Yusheng
;
Ge, Wei
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/01/03
Alzheimer's disease
Rapamycin
Cholesterol biosynthesis pathway
Cytoplasmic ribosomal proteins
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