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上海药物研究所 [23]
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Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo
期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 11
作者:
Sun, Hao
;
Bai, Xiaoyi
;
Zhang, Yiting
;
Gao, Yanan
;
Dai, Jiajia
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/06/04
Anti-tumor
SHP2
Orthosteric inhibitor
Apoptosis
Bromophenol
Acetaldehyde induces similar cytotoxic and genotoxic risks in BEAS-2B cells and HHSteCs: involvement of differential regulation of MAPK/ERK and PI3K/AKT pathways
期刊论文
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2023, 卷号: 30
作者:
Zhang, Jingni
;
Wang, Hongjuan
;
Chen, Huan
;
Liu, Yong
;
Wang, An
收藏
  |  
浏览/下载:151/0
  |  
提交时间:2023/11/17
Acetaldehyde
Cytotoxicity
Genotoxicity
BEAS-2B cells
HHSteCs
MAPK/ERK
PI3K/AKT
GP-14 protects against severe hypoxia-induced neuronal injury through the AKT and ERK pathways and its induced transcriptome profiling alteration
期刊论文
Toxicology and Applied Pharmacology, 2022, 期号: 448, 页码: 116092
作者:
Ya-Nan Geng
;
Ming Zhao
;
Jun-Li Yang
;
Xiang Cheng
;
Ying Han
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2022/11/30
Gypenoside-14 (GP-14)
Neuronal Damage
Hypoxia
Transcriptome Sequencing
Neuroprotection
DHOK Exerts Anti-Cancer Effect Through Autophagy Inhibition in Colorectal Cancer
期刊论文
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 卷号: 9
作者:
Shu, Yuhan
;
Sun, Xin
;
Ye, Guiqin
;
Xu, Mengting
;
Wu, Zhipan
收藏
  |  
浏览/下载:156/0
  |  
提交时间:2022/02/14
DHOK
transcriptome sequencing
autophagy
colorectal cancer
mTOR pathway
DCZ3301, an aryl-guanidino agent, inhibits ocular neovascularization via PI3K/AKT and ERK1/2 signaling pathways
期刊论文
EXPERIMENTAL EYE RESEARCH, 2020, 卷号: 201, 页码: 8
作者:
Xu, Kai
;
Li, Bo
;
Zhang, Shujie
;
Hu, Fangyuan
;
Xu, Zhijian
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2021/05/24
DCZ3301
Apoptosis
PI3K/AKT pathway
ERK1/2 pathway
Choroid microvascular sprouting
Corneal neovascularization
Structural elucidation of a pectin from roots of Polygala tenuifolia and its neuritogenesis inducing activity in PC12 cells
期刊论文
CARBOHYDRATE POLYMERS, 2020, 卷号: 236, 页码: 9
作者:
Zeng, Hui
;
Huang, Lulin
;
Tao, Hong
;
Zhang, Yiwen
;
Ding, Kan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Polygala tenuifolia
Pectin
Neuritogenesis
Neurodegenerative disorders
An optically active isochroman-2H-chromene conjugate potently suppresses neuronal oxidative injuries associated with the PI3K/Akt and MAPK signaling pathways
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 9
作者:
Tao, Ling-xue
;
Ji, Sha-sha
;
Szaloki, Dora
;
Kovacs, Tibor
;
Mandi, Attila
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2020/07/01
neurodegeneration
oxidative stress
apoptosis
MAPK pathway
PI3K
Akt pathway
SH-SY5Y neuroblastoma cells
Dammarane-Type Saponins from Gynostemma pentaphyllum Prevent Hypoxia-Induced Neural Injury through Activation of ERK, Akt, and CREB Pathways
期刊论文
Journal of Agricultural and Food Chemistry, 2020, 卷号: 68, 期号: 1, 页码: 193−205
作者:
Wang J(王君)
;
Zhao M(赵名)
;
Xiang Cheng
;
Ying Han
;
Tong Zhao
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2020/11/16
Gynostemma pentaphyllum
dammarane-type saponins
hypoxia-induced neural injury
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer
期刊论文
CELL METABOLISM, 2019, 卷号: 30, 期号: 6, 页码: 1107-+
作者:
Huang, Ke
;
Liang, Qian
;
Zhou, Ye
;
Jiang, Lu-lu
;
Gu, Wei-ming
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2020/07/01
Cytotoxicity and autophagy induction by graphene quantum dots with different functional groups
期刊论文
JOURNAL OF ENVIRONMENTAL SCIENCES, 2019, 卷号: 77, 页码: 198-209
作者:
Xie, Yichun
;
Wan, Bin
;
Yang, Yu
;
Cui, Xuejing
;
Xin, Yan
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2020/10/21
Graphene quantum dots
Cytotoxicity
Autophagy
Surface functional group
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