colon cancer  hypoxia  hypoxia-inducible factor-1 (HIF-1)  mutation  ten-eleven translocation 1 (TET1) protein  

Myocardin  Atherosclerosis  Inflammation  Lipid metabolism  VSMC  Abca1  MYOCD  Myocardin  AS  atherosclerosis  SRF  serum response factor  VSMC  vascular smooth muscle cell  Mrtf-A/B  Myocardin-related transcription factors A/B  Mamstr  Mef2-activating SAP transcriptional protein  SAP domain  scaffold attachment factors A and B (SAF-A and -B), Acinus, and PIAS  MADS  MCM1, Agamous, Deficiens, SRF-box transcription factor  TAD  transactivation domain  NTD  N-terminal domain  Arp5  actin-related protein 5  Tead  TEA domain transcription factor  Foxo  forkhead transcription factor  Cdc7  cell division cycle 7  Mef2  myocyte-specific enhancer factor  Nfatc3  nuclear factor of activated T cells c3  hnRNPA1  heterogeneous nuclear ribonucleoprotein A1  Tet2  ten-eleven translocation-2  TGF-β  transforming growth factor-β  URR  upstream repressor region  Klf4  Kruppel-like factor4  PRR  platelet-derived growth factor-BB-responsive region  Pkcα  protein kinase C α  MSCs  mesenchymal stem cells  lncRNAs  long non-coding RNAs  MicroRNAs  small non-encoding RNAs  UTR  un-translated region  Abca1  ATP-binding cassette transporter A1  RCT  reverse cholesterol transport  

DNA碱基损伤，毛细管电泳-激光诱导荧光（CE-LIF），维生素C，PD0325901，低甲基化  Oxidized DNA bases, Capillary electrophoresis laser-induced fluorescence (CE-LIF), Vitamin C, PD025901, Hypomet  

SSc  systemic sclerosis  SRC  scleroderma renal crisis  PAH  pulmonary arterial hypertension  SMR  standardized mortality ratio  DNMTs  DNA methyltransferases  SAM  S-adenosyl-methionine  5mC  5-methylcytosine  MBD  methyl-CpG-binding domain  Tet  ten–eleven translocation  HATs  histone acetyltransferases  HDACs  histone deacetylases  MiRNAs  microRNAs  MZ  monozygotic  DZ  dizygotic  MVECs  microvascular endothelial cells  FBs  fibroblasts  JAMs  junctional adhesion molecules  CTGF  connective tissue growth facto  TGF-β  transforming growth factor beta  CCN2  connective tissue growth factor  Fli1  Friend leukemia integration-1  TF  transcription factor  PECAM  platelet/endothelial cell adhesion molecule  PDGF  platelet derived growth factor  S1P1  sphingosin 1 phosphate  CXCL5  CXC chemokine ligand-5  BMPs  bone morphogenetic proteins  BMPRII  bone morphogenetic protein type II receptor  ET-1  endotheline-1  uPA  urokinase-type plasminogen activator  MBD  methyl-CpG-binding domain protein  ICAM  intercellular adhesion molecule  KLF5  Kruppel-like factor 5  Tregs  regulatory T cells  Runx1  Runt-related transcription factor 1  FOXP3  forkhead box protein 3 gene  ECM  extra cellular matrix  PDGF  platelet-derived growth factor  dSSc  diffuse systemic sclerosis  lSSc  limited systemic sclerosis  PCAF  protein-associated factor  Egr-1  early growth response 1  DDR2  discoidin domain receptor 2  TAB1  TGF-β activated kinase 1 binding protein 1  BAFF  B cell-activating factor  TSP-2  thrombospondin-2  MRTSS  Modified Rodnan total skin score  SDAI  Valentini scleroderma disease activity index  HC  healthy controls  SLE  systemic lupus erythematosus  SSD  scleroderma spectrum disorder  MTX  methylaminopterin  CYC  cyclophosphamide  MMF  mycophenolate mofetil  ACE  angiotensin converting enzyme  NO  nitric oxide  Systemic sclerosis  Epigenetic mechanisms  Biomarker  Therapy