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科研机构
上海药物研究所 [22]
内容类型
期刊论文 [22]
发表日期
2021 [2]
2020 [1]
2018 [4]
2015 [4]
2013 [1]
2012 [2]
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Chemistry [1]
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Absorption, distribution, metabolism, and excretion of [C-14]NBP (3-n-butylphthalide) in rats
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2021, 卷号: 1181, 页码: 9
作者:
Tian, Junjun
;
Lei, Peng
;
He, Yifei
;
Zhang, Ning
;
Ge, Xinyu
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
3-n-butylphthalide (NBP)
[C-14]NBP
Pharmacokinetics
Tissue distribution
Metabolism
Mass balance
Exploration of tissue distribution of ginsenoside Rg1 by LC-MS/MS and nanospray desorption electrospray ionization mass spectrometry
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7
作者:
Wei, Wenlong
;
Li, Zhenwei
;
Li, Haojv
;
An, Yaling
;
Qu, Hua
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2021/05/24
Ginsenoside Rg1
Nanospray desorption electrospray ionization
Tissue distribution
Spatial distribution
Pharmacokinetics and tissue distribution of remdesivir and its metabolites nucleotide monophosphate, nucleotide triphosphate, and nucleoside in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 6
作者:
Hu, Wen-juan
;
Chang, Lu
;
Yang, Ying
;
Wang, Xin
;
Xie, Yuan-chao
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2020/12/21
remdesivir
pharmacokinetics
tissue distribution
nucleotide monophosphate
nucleotide triphosphate
nucleoside
Pharmacokinetics and tissue distribution of eupatilin and its metabolite in rats by an HPLC-MS/MS method
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 159, 页码: 113-118
作者:
Wang, Xixiao
;
Ren, Jie
;
Zhu, Shixing
;
Ren, Guoqing
;
Wang, Lei
收藏
  |  
浏览/下载:86/0
  |  
提交时间:2019/01/08
Eupatilin
E-7-G
HPLC-MS/MS
Pharmacokinetic
Tissue distribution
Development and validation of a highly sensitive LC-MS/MS method for determination of brain active agent dianhydrogalactitol in mouse plasma and tissues: Application to a pharmacokinetic study
期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2018, 卷号: 1087, 页码: 90-97
作者:
Sun, Lihan
;
Wu, Huajing
;
Ren, Lianjie
;
Cong, Jiaojiao
;
Qin, Xiaohui
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
1,2:5,6-dianhydrogalactitol
Derivatization
LC-MS/MS
Plasma
Tissue distribution
Absorption, liver first-pass effect, pharmacokinetics and tissue distribution of calycosin-7-O-beta-D-glucopyranoside (C7G) and its major active metabolite, calycosin, following oral administration of C7G in rats by LC-MS/MS
期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 卷号: 148, 页码: 350-354
作者:
Tian, Xiaoting
;
Chen, Shuoji
;
Zhang, Yuanyuan
;
Chen, Luying
;
Guo, Xiaozhen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
Calycosin-7-O-beta-D-glucopyranoside
Calycosin
Pharmacokinetics
Liver first-pass effect
Tissue distribution
Comparative study of disposition of scutellarin and its major metabolite with different administration routes in rats
期刊论文
Acta Pharmaceutica Sinica, 2018, 卷号: 53, 期号: 8, 页码: 1357-1363
作者:
Zhang Yuan
;
Yu Songda
;
Zhong Dafang
;
Xu Haiyan
;
Chen Xiaoyan
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2019/01/08
scutellarin
isoscutellarin
LC-MS/MS
rat
tissue distribution
Pharmacokinetics, tissue distribution, and excretion of nomegestrol acetate in female rats
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2015, 卷号: 40, 期号: 4, 页码: 435-442
作者:
Huang, Qingbiao
;
Chen, Xiaoke
;
Zhu, Yan
;
Cao, Lin
;
Riviere, Jim E.
收藏
  |  
浏览/下载:106/0
  |  
提交时间:2019/01/08
Nomegestrol acetate
NOMAC
Pharmacokinetics
Tissue distribution
Excretion
HPLC
In-vivo and In-vitro Metabolism Study of Timosaponin B-II Using HPLC-ESI-MS (n)
期刊论文
CHROMATOGRAPHIA, 2015, 卷号: 78, 期号: 17-18, 页码: 1175-1184
作者:
Jia, Yao
;
Fu, Zhiwen
;
Li, Zhixiong
;
Hu, Pei
;
Xue, Rui
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
HPLC-ESI-MSn
Timosaponin B-II
Metabolism
Tissue distribution
preclinicalpharmacokineticsoftpn729maanovelpde5inhibitorandpredictionofitshumanpharmacokineticsusingapbpkmodel
期刊论文
actapharmacologicasinica, 2015, 卷号: 36, 期号: 12, 页码: 1528
作者:
Gao Zhiwei
;
Zhu Yunting
;
Yu Mingming
;
Zan Bin
;
Liu Jia
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
HUMAN DRUG CLEARANCE
PHOSPHODIESTERASE-5 INHIBITORS
CLINICAL PHARMACOKINETICS
ERECTILE DYSFUNCTION
TISSUE DISTRIBUTION
ORAL PHARMACOKINETICS
RECEPTOR ANTAGONIST
DIVERSE COMPOUNDS
IN-VIVO
ABSORPTION
TPN729MA
PDE5 inhibitor
erectile dysfunction
pharmacokinetics
human PK prediction
physiologically based pharmacokinetic model
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