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科研机构
上海药物研究所 [20]
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期刊论文 [20]
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2019 [1]
2018 [3]
2017 [1]
2016 [3]
2013 [2]
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Chemistry [4]
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Identification of new dual FABP4/5 inhibitors based on a naphthalene-1-sulfonamide FABP4 inhibitor
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2019, 卷号: 27, 期号: 19, 页码: 16
作者:
He, Yulong
;
Dou, Huixia
;
Gao, Dingding
;
Wang, Ting
;
Zhang, Mingming
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Dual FABP4/5 inhibitor
Structure-based design
Lipolysis inhibition
Anti-inflammatory effects
Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
收藏
  |  
浏览/下载:236/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
FABP4 inhibitors
FABP3 sparing
Structure-based design strategy
X-ray crystallography
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153
作者:
Zha, Chuantao
;
Deng, Wenjia
;
Fu, Yan
;
Tang, Shuai
;
Lan, Xiaojing
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  |  
浏览/下载:73/0
  |  
提交时间:2019/01/08
Structure-based drug design
Selective CDK4/6 inhibitors
Structure-activity relationship study
In vivo antitumor activity
Discovery and structure-activity-relationship study of novel conformationally restricted indane analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 卷号: 27, 期号: 23, 页码: 5262-5266
作者:
Zheng, Qiangang
;
Tang, Shuai
;
Fu, Xianlei
;
Chen, Ziqi
;
Ye, Yan
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Indane amide
Structure-based rational design
Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 卷号: 24, 期号: 12, 页码: 2673-2680
作者:
Xiao, Qiang
;
Qu, Rong
;
Gao, Dingding
;
Yan, Qi
;
Tong, Linjiang
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  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
5-(Methylthio)pyrimidine derivatives
Mutant selective inhibitors
Epidermal growth factor inhibitor
NSCLC
Structure-based drug design
Discovery and structure activity relationship study of novel indazole amide inhibitors for extracellular signal-regulated kinase1/2 (ERK1/2)
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 11, 页码: 2600-2604
作者:
Li, Lei
;
Liu, Feifei
;
Jin, Nan
;
Tang, Shuai
;
Chen, Zhuxi
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  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
ERK1/2 kinase inhibitor
Indazole amide
Structure based drug design
Structure-Based Discovery of PDEs Inhibitors
期刊论文
CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2016, 卷号: 16, 期号: 9, 页码: 917-933
作者:
Li, Li
;
Chen, Wuyan
;
Chen, Tiantian
;
Ren, Jing
;
Xu, Yechun
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
Crystal structure
Cyclic nucleotide signalling pathway
Family-selective inhibitor
Medicinal chemistry
Phosphodiesterases
Structure-based drug design
Identification of Novel Small Molecules as Inhibitors of Hepatitis C Virus by Structure-Based Virtual Screening
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2013, 卷号: 14, 期号: 11, 页码: 22845-22856
作者:
Li, Jing
;
Liu, Xian
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2019/01/08
hepatitis C virus (HCV)
NS3
NS4A serine protease
structure-based drug design (SBDD)
virtual screening
Virtual Screening and Structure-Based Discovery of Indole Acylguanidines as Potent beta-secretase (BACE1) Inhibitors
期刊论文
MOLECULES, 2013, 卷号: 18, 期号: 5, 页码: 5706-5722
作者:
Zou, Yiquan
;
Li, Li
;
Chen, Wuyan
;
Chen, Tiantian
;
Ma, Lanping
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2019/01/08
virtual screening
docking
structure-based lead design
crystal structure
indole acylguanidine
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