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Signalling mechanism(s) of epithelial–mesenchymal transition and cancer stem cells in tumour therapeutic resistance 期刊论文
Clinica Chimica Acta, 2018, 卷号: 483, 页码: 156-163
作者:  Cai, Zhihong;  Cao, Yijing;  Luo, Yichen;  Hu, Haobin;  Ling, Hui*
收藏  |  浏览/下载：20/0  |  提交时间：2019/12/27
Epithelial–mesenchymal transition (EMT)  Cancer stem cells (CSCs)  Signalling pathway  Chemotherapy resistance  EMT  epithelial-mesenchymal transition  CSCs  cancer stem cells  TGF-β  transforming growth factor-beta  Hh  Hedgehog  STAT  signal transducer and activator of transcription  MMPs  matrix metalloproteinases  CRPC  castration-resistant prostate cancer  Shh  Sonic Hedgehog  TGF-β  Transforming growth factor-beta  CSC  cancer stem-like cell  NF-κB  nuclear factor kappa-light-chain-enhancer of activated B cells  BCSCs  breast cancer stem cells  CAC  colitis-associated cancer  HOTAIR  HOX transcript antisense RNA  CSE  cigarette smoke extract  OSCs  ovarian cancer stem cells  ESCs  embryonic stem cells  TFs  transcription factors  MET  mesenchymal-epithelial translocations  
Suppression of CLC-3 chloride channel reduces the aggressiveness of glioma through inhibiting nuclear factor-kappaB pathway. 期刊论文
Oncotarget, 2017, 卷号: 8, 期号: 38, 页码: 63788-63798
作者:  Wang, Bing;  Xie, Jing;  He, Hai-Yong;  Huang, En-Wen;  Cao, Qing-Hua
收藏  |  浏览/下载：5/0  |  提交时间：2019/12/27
Autophagy: A double-edged sword in intervertebral disk degeneration 期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2016, 卷号: 457, 页码: 27-35
作者:  Zhang, Shu-Jun;  Yang, Wei;  Wang, Cheng;  He, Wen-Si;  Deng, Hai-Yang
收藏  |  浏览/下载：16/0  |  提交时间：2019/12/27
IVD  intervertebral disk  NP  nucleus pulposus  AF  annulus fibrosus  CEPs  cartilaginous endplates  ECM  extracellular matrix  Col II  type II collagen  Col I  type I collagen  IDD  intervertebral disk degeneration  LBP  low back pain  miRNAs  microRNAs  ADAMTS  a disintegrin and metalloprotease with thrombospondin motif  MMP  matrix metalloproteinases  HSC70  heat shock cognate protein of 70 kDa  LAMP2A  lysosome-associated membrane protein type-2 A  Atg  autophagy-related genes  ULK  uncoordinated-51-like kinase  PI3KCIII  class III phosphatidylinositol 3-kinase  mTORC1  mammalian target of rapamycin complex 1  DFCP1  double FYVE-containing protein 1  3-MA  3-methyladenine  LC3  microtubule-associated protein 1 light chain 3  PE  phosphatidyl ethanolamine  LAMP-2  lysosomal membrane protein 2  TNF-α  tumor necrosis factor-α  IL-1β  interleukin-1β  NF-κB  nuclear factor-κB  JNK  c-Jun N-terminal kinase  SIRT1  silent mating type information regulator 2 homolog 1  TGF-β1  transforming growth factor-β1  ERK1/2  extracellular signal-regulated kinase 1/2  GRP78  glucose regulated protein 78  H2O2  hydrogen peroxide  Autophagy  IVD  IDD  NP  AF  
PI3K/Akt signaling in osteosarcoma 期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 期号: Volume 444, 页码: 182-192
作者:  Zhang, Jian;  Yu, Xiao-Hua;  Yan, Yi-Guo;  Wang, Cheng;  Wang, Wen-Jun*
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/27
OS  osteosarcoma  PI3K  phosphatidylinositol 3-kinase  PTEN  phosphatase and tensin homolog  mTOR  mammalian target of rapamycin  RTKs  receptor tyrosine kinases  PDGFR  platelet-derived growth factor receptor  IGF1R  insulin-like growth factor 1 receptor  PIP2  phosphatidylinositol 4,5-biphosphate  PIP3  phosphatidylinositol 3,4,5-triphosphate  PDK1  phosphoinositide-dependent kinase 1  PH  pleckstrin homology  CDK  cyclin-dependent kinase  NF-κB  nuclear factor-κB  MDM2  Murine double minute 2  Rb  retinoblastoma  CSCs  cancer stem cells  CXCR7  CXC chemokine receptor 7  GA  gallic acid  miRNAs  microRNAs  TNF  tumor necrosis factor  HIF-1  hypoxia-inducible factor-1  ET-1  endothelin-1  ETAR  endothelin A receptor  MMP  matrix metalloproteinase.  OS  PI3K  Akt  PTEN  mTOR  
Interleukin-1β in intervertebral disk degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 262-272
作者:  Yang, Wei;  Yu, Xiao-Hua;  Wang, Cheng;  He, Wen-Si;  Zhang, Shu-Jun
收藏  |  浏览/下载：12/0  |  提交时间：2019/12/27
IDD  intervertebral disk degeneration  IL-1  interleukin-1  IVD  intervertebral disk  ECM  extracellular matrix  LBP  low back pain  MMPs  matrix metalloproteinases  NP  nucleus pulposus  AF  annulus fibrosus  Col II  type II collagen  Col I  type I collagen  NTP  N-terminal peptide  NLS  nuclear localization sequence  IL-1RII  IL-1 receptor type II  TLRs  Toll-like receptors  IL-1RI  IL-1 receptor type I  IL-1RAcP  IL-1 receptor accessory protein  TIR  Toll-like/IL-1 receptor  MyD88  myeloid differentiation factor 88  TNF  tumor necrosis factor  NF-κB  nuclear factor-kappa B  MAPK  mitogen-activated protein kinase  IL-1Ra  IL-1 receptor antagonist  IFN-γ  interferon-γ  CCL  CC chemokine ligand  CXCL  CX chemokine ligand  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  TIMPs  tissues inhibitors of metalloproteinases  VEGF  vascular endothelial growth factor  NGF  nerve growth factor  BDNF  brain-derived neurotrophic factor  ROS  reactive oxygen species  SOD  superoxide dismutase  CAT  catalase  miRNAs  microRNAs  MSCs  mesenchymal stem cells  PRP  platelet-rich plasma  IL-1  IDD  Inflammatory responses  Angiogenesis  Apoptosis  
MMPs and ADAMTSs in intervertebral disc degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 448, 页码: 238-246
作者:  Wang, Wen-Jun*;  Yu, Xiao-Hua;  Wang, Cheng;  Yang, Wei;  He, Wen-Si
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/27
IVD  intervertebral disc  IDD  intervertebral disc degeneration  ECM  extracellular matrix  MMPs  matrix metalloproteinases  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  NP  nucleus pulposus  AF  annulus fibrosus  Col I  type I collagen  Col II  type II collagen  IL-1  interleukin-1  MAPK  mitogen-activated protein kinase  MRI  magnetic resonance imaging  TIMP  tissue inhibitor of metalloproteinase  NGF  nerve growth factor  BMP  bone morphogenetic protein  TGF-β1  transforming growth factor-β1  SNPs  single nucleotide polymorphisms, miRNAs, microRNAs  LPS  lipopolysaccharide  TNF-α  tumor necrosis factor-α  NF-κB  nuclear factor κB  NO  nitric oxide  SDC4  syndecan-4  RSV  resveratrol  LfcinB  bovine lactoferricin  HO-1  heme oxygenase-1  MSCs  mesenchymal stem cells  IDD  MMPs  ADAMTSs  Col II  Aggrecan  
Interferon-γ in foam cell formation and progression of atherosclerosis 期刊论文
Clinica Chimica Acta, 2015, 卷号: 441, 页码: 33-43
作者:  Xiao-HuaYu;  JianZhang;  Xi-LongZheng;  Yun-HuaYang;  Chao-KeTang
收藏  |  浏览/下载：8/0  |  提交时间：2019/12/27
IFN-γ  interferon-γ  IFNGR  IFN-γ receptor  VSMC  vascular smooth muscle cell  IL  interleukin  LPS  lipopolysaccharide  TNF-α  tumor necrosis factor-α  STAT  signal transducer and activator of transcription  NF-κB  nuclear factor-κB  TLR  Toll-like receptor  Tyr  tyrosine  Ser  serine  PI3Ks  phosphatidyl inositol-3 kinases  miRNAs  microRNAs  TGF-β  transforming growth factor-β  Blimp-1  B lymphocyte-induced maturation protein-1  Bcl-6  B cell lymphoma-6  NOD2  nucleotide-binding oligomerization domain 2  JAK  Janus kinase  GAS  IFN-γ activation sequences  ERK  extracellular signal-regulated kinase  PKC  protein kinase C  SOCS  suppressor of cytokine signaling  IP-10  inducible protein-10  ox-LDL  oxidized low-density lipoprotein  SRs  scavenger receptors  ACAT1  Acyl coenzyme A:cholesterol acyltransferase 1  ABCA1  ATP-binding cassette transporter A1  apo E  apolipoprotein E  MMP  matrix metalloproteinase  IFN-γ  Foam cells  Atherosclerosis  Myocardial infarction  Stroke  
Interleukin-1β in intervertebral disk degeneration 期刊论文
Clinica Chimica Acta, 2015, 卷号: 450, 页码: 262-272
作者:  WeiYang;  Xiao-HuaYu;  ChengWang;  Wen-SiHe;  Shu-JunZhang
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/27
IDD  intervertebral disk degeneration  IL-1  interleukin-1  IVD  intervertebral disk  ECM  extracellular matrix  LBP  low back pain  MMPs  matrix metalloproteinases  NP  nucleus pulposus  AF  annulus fibrosus  Col II  type II collagen  Col I  type I collagen  NTP  N-terminal peptide  NLS  nuclear localization sequence  IL-1RII  IL-1 receptor type II  TLRs  Toll-like receptors  IL-1RI  IL-1 receptor type I  IL-1RAcP  IL-1 receptor accessory protein  TIR  Toll-like/IL-1 receptor  MyD88  myeloid differentiation factor 88  TNF  tumor necrosis factor  NF-κB  nuclear factor-kappa B  MAPK  mitogen-activated protein kinase  IL-1Ra  IL-1 receptor antagonist  IFN-γ  interferon-γ  CCL  CC chemokine ligand  CXCL  CX chemokine ligand  ADAMTSs  a disintegrin and metalloprotease with thrombospondin motifs  TIMPs  tissues inhibitors of metalloproteinases  VEGF  vascular endothelial growth factor  NGF  nerve growth factor  BDNF  brain-derived neurotrophic factor  ROS  reactive oxygen species  SOD  superoxide dismutase  CAT  catalase  miRNAs  microRNAs  MSCs  mesenchymal stem cells  PRP  platelet-rich plasma  IL-1  IDD  Inflammatory responses  Angiogenesis  Apoptosis  
Interferon-γ in foam cell formation and progression of atherosclerosis 期刊论文
Clinica Chimica Acta, 2015, 卷号: 441, 页码: 33-43
作者:  Yu, Xiao-Hua;  Zhang, Jian;  Zheng, Xi-Long;  Yang, Yun-Hua*;  Tang, Chao-Ke
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/27
IFN-γ  interferon-γ  IFNGR  IFN-γ receptor  VSMC  vascular smooth muscle cell  IL  interleukin  LPS  lipopolysaccharide  TNF-α  tumor necrosis factor-α  STAT  signal transducer and activator of transcription  NF-κB  nuclear factor-κB  TLR  Toll-like receptor  Tyr  tyrosine  Ser  serine  PI3Ks  phosphatidyl inositol-3 kinases  miRNAs  microRNAs  TGF-β  transforming growth factor-β  Blimp-1  B lymphocyte-induced maturation protein-1  Bcl-6  B cell lymphoma-6  NOD2  nucleotide-binding oligomerization domain 2  JAK  Janus kinase  GAS  IFN-γ activation sequences  ERK  extracellular signal-regulated kinase  PKC  protein kinase C  SOCS  suppressor of cytokine signaling  IP-10  inducible protein-10  ox-LDL  oxidized low-density lipoprotein  SRs  scavenger receptors  ACAT1  Acyl coenzyme A:cholesterol acyltransferase 1  ABCA1  ATP-binding cassette transporter A1  apo E  apolipoprotein E  MMP  matrix metalloproteinase  IFN-γ  Foam cells  Atherosclerosis  Myocardial infarction  Stroke  
Molecular mechanisms for the anti-cancer effects of diallyl disulfide 期刊论文
Food and Chemical Toxicology, 2013, 卷号: 57, 页码: 362-370
作者:  Yi, Lan;  Su, Qi*
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/27
OSCs  organosulfur compounds  DAS  diallyl sulfide  DADS  diallyl disulfide  DATS  diallyl trisulfide  MNU  testosterone- and N-methyl-N-nitrosourea  NDEA  N-nitrosodiethylamine  MPN  methyl-n-pentylnitrosamine  TPA  12-O-tetradecanoylphorbol-13-acetate  ODC  ornithine decarboxylase  QR  quinone reductase  GT  glutathione transferase  GSH  glutathione  rGSTA5  glutathione S-transferase A5  rAFAR1  aflatoxin B1 aldehyde reductase 1  AOM  azoxymethane  NDEA  nitrosodiethylamine  NAT  N-acetyltransferase  2-AAF  N-acetyl-2-aminofluorene  MAP  Mitogen-activated protein  Rac2  Ras-related C3 botulinum toxin substrate 2  NAC  N-acetyl cysteine  PARP  poly(adenosine diphosphate-ribose) polymerase  NF-κB  nuclear factor-kappa B  ER  endoplasmic reticulum  CTX  cyclophosphamide  HDAC  Histone deacetylase  MMPs  matrix metalloproteinases  (TNF)α  tumor necrosis factor  MIF  migration inhibitory factor  SSH  suppressive subtractive hybridization  Diallyl disulfide  Cell cycle  Apoptosis  Differentiation  Angiogenesis  Invasion  

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