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Low-molecular-weight chitosan relieves enterotoxigenic Escherichia coli-induced growth retardation in weaned pigs 期刊论文
INTERNATIONAL IMMUNOPHARMACOLOGY, 2020, 卷号: 78, 页码: -
作者:  Zhang, J;  Wan, J;  Wu, GZ;  Chen, DW;  Yu, B
收藏  |  浏览/下载：26/0  |  提交时间：2021/09/06
Leptin injection into the left stellate ganglion augments ischemia-related ventricular arrhythmias via sympathetic nerve activation 期刊论文
HEART RHYTHM, 2018, 卷号: 15, 期号: 4
作者:  Yu, Lilei;  Wang, Yuhong;  Zhou, Xiaoya;  Huang, Bing;  Wang, Menglong
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/05
Interaction of Group B Streptococcus sialylated capsular polysaccharides with host Siglec-like molecules dampens the inflammatory response in tilapia 期刊论文
MOLECULAR IMMUNOLOGY, 2018, 卷号: 103, 期号: 103, 页码: 182-190
作者:  Dong, Junjian[1];  Wei, Yuanzheng[2];  Sun, Chengfei[3];  Tian, Yuanyuan[4];  Hu, Jie[5]
收藏  |  浏览/下载：14/0  |  提交时间：2020/01/02
Reduced thrombin activatable fibrinolysis inhibitor and enhanced proinflammatory cytokines in acute coronary syndrome 期刊论文
MEDICINA INTENSIVA, 2017, 卷号: 41, 页码: 475-482
作者:  Pang, H.;  Zhang, C.;  Liu, F.;  Gong, X.;  Jin, X.
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/03
Advances in research on the central mechanism of hypertension 期刊论文
Journal of Xi'an Jiaotong University (Medical Sciences), 2017, 卷号: 38, 页码: 1-6
作者:  Kang, Yu-Ming;  Li, Hong-Bao;  Qi, Jie;  Yu, Xiao-Jing
收藏  |  浏览/下载：5/0  |  提交时间：2019/11/26
Advances in research on the central mechanism of heart failure 期刊论文
Journal of Xi'an Jiaotong University (Medical Sciences), 2017, 卷号: 38, 页码: 157-160
作者:  Kang, Yu-Ming;  Li, Xiang;  Li, Hong-Bao
收藏  |  浏览/下载：3/0  |  提交时间：2019/11/26
NAD(+) dependent deacetylase Sirtuin 5 rescues the innate inflammatory response of endotoxin tolerant macrophages by promoting acetylation of p65 期刊论文
2017, 卷号: 81, 页码: 120-129
作者:  Qin Kewei;  Han Chaofeng;  Zhang Hua;  Li Tianliang
收藏  |  浏览/下载：5/0  |  提交时间：2020/01/04
Water-soluble ginseng oligosaccharides protect against scopolamine-induced cognitive impairment by functioning as an antineuroinflammatory agent 期刊论文
JOURNAL OF GINSENG RESEARCH, 2016, 卷号: 40, 期号: 3
作者:  Zhang, Chunxiao;  Xu, Ting;  Shen, Xiangfeng;  Yu, Huali;  Sun, Lili
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/05
Protective effects of oridonin on the sepsis in mice 期刊论文
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES, 2016, 卷号: 32, 期号: 9
作者:  Zhao, Yan-Jun;  Lv, Hu;  Xu, Ping-Bo;  Zhu, Min-Min;  Liu, Yi
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/06
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  

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