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上海药物研究所 [3]
复旦大学上海医学院 [2]
长春光学精密机械与物... [1]
四川大学 [1]
上海大学 [1]
华中师范大学 [1]
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期刊论文 [10]
发表日期
2018 [10]
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Discovery and structure-activity-relationship study of novel imidazole cyclopropyl amine analogues for mutant isocitric dehydrogenase 1 (IDH1) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 23-24, 页码: 3808-3812
作者:
Zheng, Qiangang
;
Chen, Ziqi
;
Wan, Huixin
;
Tang, Shuai
;
Ye, Yan
收藏
  |  
浏览/下载:236/0
  |  
提交时间:2019/01/08
IDH1 inhibitor
Imidazole cyclopropyl amine
Structure-based rational design
From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154, 页码: 44-59
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
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  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
FABP4 inhibitors
FABP3 sparing
Structure-based design strategy
X-ray crystallography
Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 148, 页码: 140-153
作者:
Zha, Chuantao
;
Deng, Wenjia
;
Fu, Yan
;
Tang, Shuai
;
Lan, Xiaojing
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  |  
浏览/下载:73/0
  |  
提交时间:2019/01/08
Structure-based drug design
Selective CDK4/6 inhibitors
Structure-activity relationship study
In vivo antitumor activity
From hit to lead: Structure-based discovery of naphthalene-1 sulfonamide derivatives as potent and selective inhibitors of fatty acid binding protein 4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 154
作者:
Gao, Ding-Ding
;
Dou, Hui-Xia
;
Su, Hai-Xia
;
Zhang, Ming-Ming
;
Wang, Ting
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
FABP4 inhibitors
FABP3 sparing
Structure-based design strategy
X-ray crystallography
Design, synthesis and biological evaluation of novel 3-substituted pyrazolopyrimidine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 8
作者:
Zheng, Nan
;
Pan, Jing
;
Hao, Qun
;
Li, Yingxia
;
Zhou, Weicheng
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  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
BTK inhibitors
3-Substituted pyrazolopyrimidine
Structure-based drug design
Inhibitory activity
ClogP
Structure-based discovery of selective BRPF1 bromodomain inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 155
作者:
Zhu, Jian
;
Zhou, Chunxian
;
Caflisch, Amedeo
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浏览/下载:5/0
  |  
提交时间:2019/12/05
BRPF1 bromodomain
Pharmacophore search
Structure-based drug design
X-ray crystallography
Isothermal titration calorimetry
Molecular dynamics
Structure-based discovery of selective BRPF1 bromodomain inhibitors
期刊论文
European journal of medicinal chemistry, 2018, 卷号: 155, 页码: 337-352
作者:
Zhu Jian[1]
;
Zhou Chunxian[2]
;
Caflisch Amedeo[3]
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  |  
浏览/下载:6/0
  |  
提交时间:2019/04/22
BRPF1 bromodomain
Isothermal titration calorimetry
Molecular dynamics
Pharmacophore search
Structure-based drug design
X-ray crystallography
Structural insights into drug development strategy targeting EGFR T790M/C797S
期刊论文
Oncotarget, 2018, 卷号: Vol.9 No.17, 页码: 13652-13665
作者:
Zhu, S.-J.
;
Zhao, P.
;
Yang, J.
;
Ma, R.
;
Yan, X.-E.
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  |  
浏览/下载:12/0
  |  
提交时间:2019/02/25
Drug
resistance
Lung
cancer
Structure-based
drug
design
T790M/C797S
X-ray
crystallography
Design, Synthesis, and Herbicidal Activity of Pyrimidine-Biphenyl Hybrids as Novel Acetohydroxyacid Synthase Inhibitors
期刊论文
Journal of Agricultural and Food Chemistry, 2018, 卷号: 66, 期号: 15, 页码: 3773-3782
作者:
Li, Ke-Jian
;
Qu, Ren-Yu
;
Liu, Yu-Chao
;
Yang, Jing-Fang
;
Devendar, Ponnam
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/23
acetohydroxyacid synthase
herbicide
pyrimidine-biphenyl
structure-based design
weed resistance
A novel passive micromixer with modified asymmetric lateral wall structures
期刊论文
Asia-Pacific Journal of Chemical Engineering, 2018, 卷号: 13, 期号: 3, 页码: 11
作者:
Wang, H. L.
;
Shi, L. Y.
;
Zhou, T.
;
Xu, C.
;
Deng, Y. B.
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  |  
浏览/下载:8/0
  |  
提交时间:2019/09/17
lateral structure
microfluidics
numerical simulations
passive
micromixer
secondary flow
cfd-based optimization
recombination micromixer
microfluidic chip
design
membranes
stirrer
mixers
Engineering
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