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科研机构
西安交通大学 [1]
华中师范大学 [1]
中国医学科学院 北京... [1]
内容类型
期刊论文 [3]
发表日期
2015 [3]
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Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study.
期刊论文
Advances in therapy, 2015, 卷号: 32, 期号: [db:dc_citation_issue], 页码: 1140-59
作者:
Wu Depei
;
Du Xin
;
Jin Jie
;
Xiao Zhijian
;
Shen Zhixiang
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/02
Myelodysplastic syndrome (MDS)
Oncology
Phase 3b
Hematology
Chinese population
Decitabine
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation
期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:
Liu, Ke
;
Liu, Yanli
;
Lau, Johnathan L
;
Min, Jinrong*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/23
Histone demethylation
DNA methylation
Inhibitor
Chemical probe
Drug discovery
LSD
lysine-specific histone demethylase
HDAC
histone deacetylase
REST
REST corepressor
DNMT
DNA methyltransferase
MAO
monoamine oxidase
AML
acute myeloid leukemia
KDM
lysine-specific demethylase
MLL
mixed lineage leukemia
FAD
flavin adenine dinucleotide
PCPA
trans-2-phenylcyclopropylamine
2,4-PDCA
2, 4-pyridinedicarboxylic acid
PHD
plant homeobox domain
SCLC
small cell lung cancer
JHDMs
JmjC-domain-containing histone demethylases
NOG
N-oxalylglycine
IOX1
5-carboxy-8-hydroxyquinoline
MDS
myelodysplastic syndrome
2-OG, 2-oxoglutarate or
α-ketoglutarate
G9a
euchromatic histone-lysine N-methyltransferase 2
CoREST complex
restin corepressor complex
SAH
S-adenosyl-l-homocysteine
l
SWI complex
ATP dependent chromatin remodeling complexes
Pan-Histone Demethylase Inhibitor
the inhibitor can simultaneously inhibit both LSDs and JHDMs
LSC colony
leukemic stem cell colony
Pan JmjC domain-containing demethylase inhibitor
the inhibitor can simultaneously inhibit all the members of JHDMs
E2F1
E2F transcription factor 1
E2F2
E2F transcription factor 2
RCC
renal cell carcinoma
Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study
期刊论文
2015, 卷号: 32, 期号: 11, 页码: 1140-1159
作者:
Wu, Depei
;
Du, Xin
;
Jin, Jie
;
Xiao, Zhijian
;
Shen, Zhixiang
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/01/13
Chinese population
Decitabine
Hematology
Myelodysplastic syndrome (MDS)
Oncology
Phase 3b
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