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Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study. 期刊论文
Advances in therapy, 2015, 卷号: 32, 期号: [db:dc_citation_issue], 页码: 1140-59
作者:  Wu Depei;  Du Xin;  Jin Jie;  Xiao Zhijian;  Shen Zhixiang
收藏  |  浏览/下载:10/0  |  提交时间:2019/12/02
Epigenetic targets and drug discovery Part 2: Histone demethylation and DNA methylation 期刊论文
Pharmacology and Therapeutics, 2015, 卷号: 151, 页码: 121-140
作者:  Liu, Ke;  Liu, Yanli;  Lau, Johnathan L;  Min, Jinrong*
收藏  |  浏览/下载:13/0  |  提交时间:2019/12/23
Histone demethylation  DNA methylation  Inhibitor  Chemical probe  Drug discovery  LSD  lysine-specific histone demethylase  HDAC  histone deacetylase  REST  REST corepressor  DNMT  DNA methyltransferase  MAO  monoamine oxidase  AML  acute myeloid leukemia  KDM  lysine-specific demethylase  MLL  mixed lineage leukemia  FAD  flavin adenine dinucleotide  PCPA  trans-2-phenylcyclopropylamine  2,4-PDCA  2, 4-pyridinedicarboxylic acid  PHD  plant homeobox domain  SCLC  small cell lung cancer  JHDMs  JmjC-domain-containing histone demethylases  NOG  N-oxalylglycine  IOX1  5-carboxy-8-hydroxyquinoline  MDS  myelodysplastic syndrome  2-OG, 2-oxoglutarate or  α-ketoglutarate  G9a  euchromatic histone-lysine N-methyltransferase 2  CoREST complex  restin corepressor complex  SAH  S-adenosyl-l-homocysteine  l  SWI complex  ATP dependent chromatin remodeling complexes  Pan-Histone Demethylase Inhibitor  the inhibitor can simultaneously inhibit both LSDs and JHDMs  LSC colony  leukemic stem cell colony  Pan JmjC domain-containing demethylase inhibitor  the inhibitor can simultaneously inhibit all the members of JHDMs  E2F1  E2F transcription factor 1  E2F2  E2F transcription factor 2  RCC  renal cell carcinoma  
Decitabine for Treatment of Myelodysplastic Syndromes in Chinese Patients: An Open-Label, Phase-3b Study 期刊论文
2015, 卷号: 32, 期号: 11, 页码: 1140-1159
作者:  Wu, Depei;  Du, Xin;  Jin, Jie;  Xiao, Zhijian;  Shen, Zhixiang
收藏  |  浏览/下载:3/0  |  提交时间:2020/01/13


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