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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 专题：合肥物质科学研究院    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Discovery of 4-(((4-(5-chloro-2-(((1s,4s)-4-((2-methoxyethyl)amino) cyclohexyl)amino)pyridin-4-yl)thiazol-2-yl)amino)methyl) tetrahydro-2H-pyran-4-carbonitrile (JSH-150) as a novel highly selective and potent CDK9 kinase inhibitor 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 158, 页码: 896-916 作者:  Wang, Beilei;  Wu, Jiaxin;  Wu, Yun;  Chen, Cheng;  Zou, Fengming 收藏  |  浏览/下载：66/0  |  提交时间：2019/12/25 CDK9  Kinase inhibitor  Structure-activity relationship  Leukemia   Discovery of 4-((N-(2-(dimethylamino)ethyl)acrylamido)methyl)-N-(4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide (CHMFL-PDGFR-159) as a highly selective type II PDGFR alpha kinase inhibitor for PDGFR alpha driving chronic eosinophilic leukemia 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 150, 期号: 无, 页码: 366-384 作者:  Wang, Qiang;  Liu, Feiyang;  Qi, Shuang;  Qi, Ziping;  Yan, Xiao-E. 收藏  |  浏览/下载：63/0  |  提交时间：2019/06/10 PDGFR kinase  Type II inhibitor  Kinase inhibitor  CEL   Discovery of 4-Methyl-N-(44(4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-((1-nicotinoylpiperidin-4-y1)oxy)benzamide (CHMFL-ABL/KIT-155) as a Novel Highly Potent Type II ABL/KIT Dual Kinase Inhibitor with a Distinct Hinge Binding 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 60, 期号: 1, 页码: 273-289 作者:  Wang, Qiang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Qi, Ziping 收藏  |  浏览/下载：29/0  |  提交时间：2018/07/04 Discovery of N-((1-(4-(3-(3-((6,7-Dimethoxyquinolin-3-yl)oxy)phenyl)ureido)-2-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)propionamide (CHMFL-KIT-8140) as a Highly Potent Type II Inhibitor Capable of Inhibiting the T670I "Gatekeeper" Mutant of cKIT Kinase 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 18, 页码: 8456-8472 作者:  Li, Binhua;  Wang, Aoli;  Liu, Juan;  Qi, Ziping;  Liu, Xiaochuan 收藏  |  浏览/下载：41/0  |  提交时间：2017/11/21 Simultaneous inhibition of Vps34 kinase would enhance PI3K delta inhibitor cytotoxicity in the B-cell malignancies 期刊论文 ONCOTARGET, 2016, 卷号: 7, 期号: 33, 页码: 53515-53525 作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Liu, Juanjuan;  Zou, Fengming 收藏  |  浏览/下载：34/0  |  提交时间：2017/11/21 Pi3k Delta  Vps34  Combination  Chronic Lymphatic Leukemia  Acute Myeloid Leukemia   Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML) 期刊论文 ONCOTARGET, 2016, 卷号: 7, 期号: 29, 页码: 45562-45574 作者:  Liu, Feiyang;  Wang, Beilei;  Wang, Qiang;  Qi, Ziping;  Chen, Cheng 收藏  |  浏览/下载：39/0  |  提交时间：2017/11/21 Bcr-abl  Pdgfr  Chronic Myeloid Leukemia  Kinase Inhibitor   Characterization of selective and potent PI3K delta inhibitor (PI3KD-IN-015) for B-Cell malignances 期刊论文 ONCOTARGET, 2016, 卷号: 7, 期号: 22, 页码: 32641-32651 作者:  Liu, Xiaochuan;  Wang, Aoli;  Liang, Xiaofei;  Chen, Cheng;  Liu, Juanjuan 收藏  |  浏览/下载：21/0  |  提交时间：2017/11/16 Pi3k Delta  Leukemia  B-cell Malignances  Pi3k  Kinase Inhibitors   Dual Inhibition of AKT/FLT3-ITD by A674563 Overcomes FLT3 Ligand-Induced Drug Resistance in FLT3-ITD positive AML 期刊论文 ONCOTARGET, 2016, 卷号: 7, 期号: 20, 页码: 29131-29142 作者:  Wang, Aoli;  Wu, Hong;  Chen, Cheng;  Hu, Chen;  Qi, Ziping 收藏  |  浏览/下载：15/0  |  提交时间：2017/11/16 Acute Myeloid Leukemia  Flt3-itd  Akt  A6745763  Flt3-ligand   Discovery of N-(34(1-lsonicotinoylpiperidin-4-yl)oxy)-4methylpheny1)-3-(trifluoromethyl)benzamide (CHMFL-KIT-110) as a Selective, Potent, and Orally Available Type II c-KIT Kinase Inhibitor for Gastrointestinal Stromal Tumors (GISTs) 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2016, 卷号: 59, 期号: 8, 页码: 3964-3979 作者:  Wang, Qang;  Liu, Feiyang;  Wang, Beilei;  Zou, Fengming;  Chen, Cheng 收藏  |  浏览/下载：15/0  |  提交时间：2017/11/10 Discovery of a Selective Irreversible BMX Inhibitor for Prostate Cancer 期刊论文 acs chemical biology, 2013, 期号: 8, 页码: 1423-1428 Feiyang Liu; Xin Zhang; Hong Wu; Zheng Zhao; Wenchao Wang; Mao Mao; Qingsong Liu etc 收藏  |  浏览/下载：30/0  |  提交时间：2014/11/12