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浏览/检索结果: 共12条，第1-10条 帮助 限定条件 专题：山东大学    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus 期刊论文 ORGANIC & BIOMOLECULAR CHEMISTRY, 2019, 卷号: 17, 期号: 12, 页码: 3202-3217 作者:  Zhou, Zhongxia;  Liu, Tao;  Wu, Gaochan;  Kang, Dongwei;  Fu, Zhipeng 收藏  |  浏览/下载：11/0  |  提交时间：2019/12/11 Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors 期刊论文 DRUG DISCOVERY TODAY, 2019, 卷号: 24, 期号: 2, 页码: 629-635 作者:  Jing, Lanlan;  Wu, Gaochan;  Kang, Dongwei;  Zhou, Zhongxia;  Song, Yuning 收藏  |  浏览/下载：9/0  |  提交时间：2019/12/11 Influenza A virus polymerase: an attractive target for next-generation anti-influenza therapeutics 期刊论文 DRUG DISCOVERY TODAY, 2018, 卷号: 23, 期号: 3, 页码: 503-518 作者:  Zhou, Zhongxia;  Liu, Tao;  Zhang, Jian;  Zhan, Peng;  Liu, Xinyong 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11 First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 卷号: 28, 期号: 8, 页码: 1348-1351 作者:  Huang, Boshi;  Liu, Xinhao;  Tian, Ye;  Kang, Dongwei;  Zhou, Zhongxia 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/11 HIV-1 NNRTI  RDEA427  Carbonate prodrug  Anti-HIV activity  Metabolic  stability   Current insights into anti-HIV drug discovery and development: a review of recent patent literature (2014-2017) 期刊论文 EXPERT OPINION ON THERAPEUTIC PATENTS, 2018, 卷号: 28, 期号: 4, 页码: 299-316 作者:  Zuo, Xiaofang;  Huo, Zhipeng;  Kang, Dongwei;  Wu, Gaochan;  Zhou, Zhongxia 收藏  |  浏览/下载：6/0  |  提交时间：2019/12/11 HIV-1  AIDS  inhibitors  drug design  medicinal chemistry  hit-to-lead  optimization   Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel" 期刊论文 ORGANIC & BIOMOLECULAR CHEMISTRY, 2018, 卷号: 16, 期号: 6, 页码: 1014-1028 作者:  Zhou, Zhongxia;  Liu, Tao;  Kang, Dongwei;  Huo, Zhipeng;  Wu, Gaochan 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 Novel diaryltriazines with a picolinonitrile moiety as potent HIV-1 RT inhibitors: a patent evaluation of WO2016059647(A2) 期刊论文 EXPERT OPINION ON THERAPEUTIC PATENTS, 2017, 卷号: 27, 期号: 1, 页码: 9-15 作者:  Huang, Boshi;  Zhou, Zhongxia;  Kang, Dongwei;  Li, Wanzhuo;  Chen, Zihui 收藏  |  浏览/下载：7/0  |  提交时间：2019/12/16 Diaryltriazine  HIV-1 RT inhibitors  picolinonitrile  modeling  simulation  highly conserved residues   Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 126, 页码: 190-201 作者:  Li, Xiao;  Gao, Ping;  Huang, Boshi;  Zhou, Zhongxia;  Yu, Zhao 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/11 HIV  NNRTIs  Indolylarylsulfones  Antiviral activity  SAR  Molecular  modeling  Chemical space  Drug design   Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 130, 页码: 209-222 作者:  Zhang, Heng;  Tian, Ye;  Kang, Dongwei;  Huo, Zhipeng;  Zhou, Zhongxia 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/12 NNRTIs  DAPYs  Uracil  Molecular hybridization  Physicochemical  properties  Drug design   Arylazolyl(azinyl)thioacetanilides: Part 19: Discovery of Novel Substituted Imidazo[4,5-b]pyridin-2-ylthioacetanilides as Potent HIV NNRTIs Via a Structure-based Bioisosterism Approach 期刊论文 CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 卷号: 88, 期号: 2, 页码: 241-253 作者:  Li, Xiao;  Huang, Boshi;  Zhou, Zhongxia;  Gao, Ping;  Pannecouque, Christophe 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/17 antiviral activity  drug design  HIV  imidazo[4,5-b]pyridin-2-ylthioacetanilides  molecular modeling  NNRTIs  SAR