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CORC

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The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression 期刊论文
NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 17
作者:  Li, Xinzhi;  Yuan, Bingchuan;  Lu, Min;  Wang, Yuqin;  Ding, Na
收藏  |  浏览/下载：39/0  |  提交时间：2022/01/18
Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2021, 卷号: 1241, 页码: 14
作者:  Zhou, Xian;  Feng, Xuexin;  Wang, Dachi;  Chen, Deheng;  Wu, Gaoxing
收藏  |  浏览/下载：86/0  |  提交时间：2021/08/17
Discovery of an M-Substituted N-Cyclopropylmethyl-7 alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 16, 页码: 12414-12433
作者:  He, Qian;  Wei, Yuanyuan;  Liu, Xiao;  Ye, Rongrong;  Kong, Linghui
收藏  |  浏览/下载：88/0  |  提交时间：2021/11/04
Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 13, 页码: 9458-9483
作者:  Huang, Huoming;  Li, Xueping;  Xie, Peng;  Li, Xinwei;  Xu, XueJun
收藏  |  浏览/下载：29/0  |  提交时间：2021/08/17
Discovery of a novel, potent and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumour efficacy 期刊论文
BRITISH JOURNAL OF PHARMACOLOGY, 2021, 页码: 20
作者:  Liu, Chenglong;  Zhou, Feilong;  Yan, Ziqin;  Shen, Lian;  Zhang, Xichen
收藏  |  浏览/下载：26/0  |  提交时间：2021/06/11
Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 6, 页码: 1018-1030
作者:  Liu, Xiao;  Jiang, Shuang;  Kong, Linghui;  Ye, Rongrong;  Xiao, Li
收藏  |  浏览/下载：114/0  |  提交时间：2021/05/24
Diversified strategy for the synthesis of DNA-encoded oxindole libraries 期刊论文
CHEMICAL SCIENCE, 2021, 卷号: 12, 期号: 8, 页码: 2841-2847
作者:  Wang, Xuan;  Liu, Jiaxiang;  Yan, Ziqin;  Liu, Xiaohong;  Liu, Sixiu
收藏  |  浏览/下载：23/0  |  提交时间：2021/05/24
Design, Synthesis, and Structure-Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective mu Opioid Receptor Agonists 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2021, 卷号: 12, 期号: 2, 页码: 285-299
作者:  Huang, Huoming;  Li, Xinwei;  Guo, Wei;  Zhu, Chen;  Qian, Yuanyuan
收藏  |  浏览/下载：26/0  |  提交时间：2021/05/24
SARS-CoV-2 and Three Related Coronaviruses Utilize Multipke ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig 期刊论文
JOURNAL OF VIROLOGY, 2020, 卷号: 94, 期号: 22, 页码: 14
作者:  Li, Yujun;  Wang, Haimin;  Tang, Xiaojuan;  Fang, Shisong;  Ma, Danting
收藏  |  浏览/下载：25/0  |  提交时间：2020/12/21
Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1) 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 195, 页码: 13
作者:  Zhang, Shiyan;  Huang, Chaoying;  Lyu, Xilin;  Wang, Peipei;  Zang, Yi
收藏  |  浏览/下载：41/0  |  提交时间：2020/07/01

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