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科研机构
上海药物研究所 [20]
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期刊论文 [20]
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2020 [1]
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Pharmacokinetics, mass balance, and metabolism of [C-14]vicagrel, a novel irreversible P2Y(12) inhibitor in humans
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Zheng, Yuan-dong
;
Zhang, Hua
;
Zhan, Yan
;
Bian, Yi-cong
;
Ma, Sheng
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/05/24
vicagrel
[C-14]vicagrel
vicagrel pharmacokinetics
vicagrel metabolism
mass balance
P2Y(12) receptor inhibitor
A systematic analysis of FDA-approved anticancer drugs
期刊论文
BMC SYSTEMS BIOLOGY, 2017, 卷号: 11, 页码: 27-43
作者:
Sun, Jingchun
;
Wei, Qiang
;
Zhou, Yubo
;
Wang, Jingqi
;
Liu, Qi
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2019/01/08
Anticancer drugs
Drug-cancer network
Cancer-drug-target network
Drug repurposing
Recent applications of chiral N-tert-butanesulfinyl imines, chiral diene ligands and chiral sulfur-olefin ligands in asymmetric synthesis
期刊论文
Organic Chemistry Frontiers, 2015, 卷号: 2, 期号: 1, 页码: 73-89
作者:
Dong, Han-Qing
;
Xu, Ming-Hua
;
Feng, Chen-Guo
;
Sun, Xing-Wen
;
Lin, Guo-Qiang
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
Pharmacological characterization and therapeutic potential for the treatment of opioid abuse with ATPM-ET, an N-ethyl substituted aminothiazolomorphinan with kappa agonist and mu agonist/antagonist activity
期刊论文
EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 卷号: 740, 页码: 455-463
作者:
Sun, Jian-Feng
;
Wang, Yu-Hua
;
Chai, Jing-Rui
;
Li, Fu-Ying
;
Hang, Ai
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
kappa against and mu agonistfantagonist
Antinociception
Sedation
CPP
Heroin self-administration
Reinstatement of drug seeking behavior
The advantage of biosensor analysis over enzyme inhibition studies for slow dissociating inhibitors - characterization of hydroxamate-based matrix metalloproteinase-12 inhibitors
期刊论文
MEDCHEMCOMM, 2013, 卷号: 4, 期号: 2, 页码: 432-442
作者:
Gossas, Thomas
;
Nordstrom, Helena
;
Xu, Ming-Hua
;
Sun, Zhi-Hua
;
Lin, Guo-Qiang
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Synthesis and Biological Evaluation of Heterocyclic Ring-substituted Chalcone Derivatives as Novel Inhibitors of Protein Tyrosine Phosphatase 1B
期刊论文
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 卷号: 33, 期号: 5, 页码: 1505-1508
作者:
Chen, Zhen-Hua
;
Sun, Liang-Peng
;
Zhang, Wei
;
Shen, Qiang
;
Gao, Li-Xin
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/01/08
Chalcone
Protein tyrosine phosphatase 1B
Inhibitor
SAR
Synthesis and biological evaluation of (+/-)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2011, 卷号: 46, 期号: 9, 页码: 3630-3638
作者:
Sun, Liang-Peng
;
Shen, Qiang
;
Piao, Hong-Hua
;
Ma, Wei-Ping
;
Gao, Li-Xin
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/01/08
Protein tyrosine phosphatase 1B
Inhibitors
2-Naphthol tyrosine
SAR
Diabetes
Effects of ATPM-ET, a novel kappa agonist with partial mu activity, on morphine-induced physical dependence and behavior sensitization in mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 12, 页码: 1547-1552
作者:
Sun, Jian-feng
;
Wang, Yu-hua
;
Li, Fu-ying
;
Lu, Gang
;
Tao, Yi-min
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
behavioral sensitization
mu opioid receptors
morphine
kappa opioid receptors
physical dependence
addiction
The role of kappa-opioid receptor activation in mediating antinociception and addiction
期刊论文
ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 9, 页码: 1065-1070
作者:
Wang, Yu-hua
;
Sun, Jian-feng
;
Tao, Yi-min
;
Chi, Zhi-qiang
;
Liu, Jing-gen
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2019/01/08
kappa-opioid receptor
dynorphin
desensitization
antinociception
tolerance
addiction
drug withdrawal
cocaine reward
negative mood state
Adenosine A(1) receptor agonist N-6-cyclohexyladenosine induced phosphorylation of delta oploid receptor and desensitization of its signaling opioid
期刊论文
ACTA PHARMACOLOGICA SINICA, 2010, 卷号: 31, 期号: 7, 页码: 784-790
作者:
Cheng, Yun
;
Tao, Yi-min
;
Sun, Jian-feng
;
Wang, Yu-hua
;
Xu, Xue-jun
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
adenosine A(1) receptor
N-6-cyclohexyladenosine
delta opioid receptor
cAMP
Akt
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