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科研机构
上海药物研究所 [14]
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期刊论文 [14]
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2021 [5]
2020 [1]
2017 [3]
2015 [1]
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Forrestiacids A and B, Pentaterpene Inhibitors of ACL and Lipogenesis: Extending the Limits of Computational NMR Methods in the Structure Assignment of Complex Natural Products
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 7
作者:
Xiong, Juan
;
Zhou, Peng-Jun
;
Jiang, Hao-Wen
;
Huang, Ting
;
He, Yu-Hang
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2021/11/04
forrestiacids
lipogenesis inhibitors
natural products
structure elucidation
terpenoids
Discovery of MTR-106 as a highly potent G-quadruplex stabilizer for treating BRCA-deficient cancers
期刊论文
INVESTIGATIONAL NEW DRUGS, 2021, 页码: 9
作者:
Li, Meng-Zhu
;
Meng, Tao
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Ma, Lan-Ping
收藏
  |  
浏览/下载:69/0
  |  
提交时间:2021/05/24
G-quadruplex stabilizer
MTR-106
BRCA-deficiency
PARP inhibitor
DNA damage
Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yong-zhen
;
Lu, Heng-lei
;
Qi, Xin-ming
;
Xing, Guo-zhen
;
Wang, Xin
收藏
  |  
浏览/下载:72/0
  |  
提交时间:2021/05/24
aristolochic acid I
glutathione S-transferase placental form-positive foci
clonal expansion
hepatocellular carcinoma
medium-term rat liver bioassay
DNA adducts
Glycogen synthase kinase 3 beta inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
CELL DEATH & DISEASE, 2021, 卷号: 12, 期号: 2, 页码: 18
作者:
Zhang, Ning
;
Tian, Yu-Nan
;
Zhou, Li-Na
;
Li, Meng-Zhu
;
Chen, Hua-Dong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/05/24
Glycogen synthase kinase 3β inhibition synergizes with PARP inhibitors through the induction of homologous recombination deficiency in colorectal cancer
期刊论文
Cell Death & Disease, 2021, 卷号: 12, 期号: 2, 页码: 1
作者:
Ning Zhang
;
Yu-Nan Tian
;
Li-Na Zhou
;
Meng-Zhu Li
;
Hua-Dong Chen
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2021/12/01
Stewartiacids A-N, C-23 carboxylated triterpenoids from Chinese Stewartia and their inhibitory effects against ATP-citrate lyase and NF-kappa B
期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 6, 页码: 3343-3356
作者:
Wan, Jiang
;
Zang, Yi
;
Xiao, Dao-An
;
Li, Na
;
Li, Junmin
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2020/07/01
Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse nonalcoholic steatohepatitis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 5, 页码: 660-671
作者:
Liu, Ming-xia
;
Gao, Man
;
Li, Chun-zhu
;
Yu, Cun-zhi
;
Yan, Hong
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2019/01/08
non-alcoholic steatohepatitis
cholesterol accumulation
Dicer1
HMGCR
microRNA-29
MCD diet-treated mice
Novel PARP1/2 inhibitor mefuparib hydrochloride elicits potent in vitro and in vivo anticancer activity, characteristic of high tissue distribution
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 4156-4168
作者:
He, Jin-Xue
;
Wang, Meng
;
Huan, Xia-Juan
;
Chen, Chuan-Huizi
;
Song, Shan-Shan
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
MPH
PARP inhibitor
homologous recombination
antitumor activity
synthetic lethality
MicroRNA-1304 suppresses human non-small cell lung cancer cell growth in vitro by targeting heme oxygenase-1
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 1, 页码: 110-119
作者:
Li, Cheng-gang
;
Pu, Meng-fan
;
Li, Chun-zhu
;
Gao, Man
;
Liu, Ming-xia
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
miR-1304
NSCLC
heme oxygenase-1
hemin
¹H-NMR and MS based metabolomics study of the intervention effect of curcumin on hyperlipidemia mice induced by high-fat diet
期刊论文
PloS one, 2015, 卷号: 10, 期号: 3, 页码: e0120950
作者:
Li, Ze-Yun
;
Ding, Li-Li
;
Li, Jin-Mei
;
Xu, Bao-Li
;
Yang, Li
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/01/08
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