QQ客服 官方微博 反馈留言

浏览/检索结果: 共9条，第1-9条 帮助 限定条件 专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Allosteric Regulation of Hsp90 alpha's Activity by Small Molecules Targeting the Middle Domain of the Chaperone 期刊论文 ISCIENCE, 2020, 卷号: 23, 期号: 2, 页码: 46 作者:  Zhou, Chen;  Zhang, Chi;  Zhu, Hongwen;  Liu, Zhijun;  Su, Haixia 收藏  |  浏览/下载：147/0  |  提交时间：2020/07/01 Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core (vol 26, pg 5399, 2016) 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 4, 页码: 1 作者:  Han, Mei;  Wang, Chengyan;  Ji, Yinchun;  Song, Zilan;  Xing, Li 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models 期刊论文 ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 243-250 作者:  Jiang, Xi-fei;  Dai, Yang;  Peng, Xia;  Shen, Yan-yan;  Su, Yi 收藏  |  浏览/下载：54/0  |  提交时间：2019/01/08 human cancer  anticancer drug  SOMCL-085  receptor tyrosine kinase  FGFR  xenograft nude mouse model   somcl085anovelmultitargetedfgfrinhibitordisplayspotentanticanceractivityinfgfraddictedhumancancermodels 期刊论文 actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 243 作者:  Jiang Xifei;  Dai Yang;  Peng Xia;  Shen Yanyan;  Su Yi 收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01 human cancer  anticancer drug  SOMCL-085  receptor tyrosine kinase  FGFR  xenograft nude mouse model   Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors 期刊论文 ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1038-1047 作者:  Yang, Zhong-min;  Liao, Xue-mei;  Chen, Yi;  Shen, Yan-yan;  Yang, Xin-ying 收藏  |  浏览/下载：26/0  |  提交时间：2019/01/08 homologous recombination repair defects  breast cancer  ovarian cancer  TALEN  combined biomarker  simmiparib  olaparib   Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials 期刊论文 CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56 作者:  Yuan, Bo;  Ye, Na;  Song, Shan-Shan;  Wang, Yu-Ting;  Song, Zilan 收藏  |  浏览/下载：43/0  |  提交时间：2019/01/08 Homologous recombination repair defects  Olaparib  Growth inhibition  Patient-derived xenografts  Pharmacokinetics   SAR study of 5-alkynyl substituted quinazolin-4(3H)-ones as phosphoinositide 3-kinase delta (PI3K delta) inhibitors 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 1156-1171 作者:  Wei, Manman;  Zhang, Xi;  Wang, Xiang;  Song, Zilan;  Ding, Jian 收藏  |  浏览/下载：18/0  |  提交时间：2019/01/08 Chronic lymphocytic leukemia  PI3K delta  Structure-activity relationship  5-Alkynyl  Quinazolinone   combining53bp1withbrca1asabiomarkertopredictthesensitivityofpolyadpribosepolymeraseparpinhibitors 期刊论文 actapharmacologicasinica, 2017, 卷号: 38, 期号: 7, 页码: 1036 作者:  Yang Zhongmin;  Liao Xuemei;  Chen Yi;  Shen Yanyan;  Yang Xinying 收藏  |  浏览/下载：8/0  |  提交时间：2020/07/01 homologous recombination repair defects  breast cancer  ovarian cancer  TALEN  combined biomarker  simmiparib  olaparib   Metabolism-based structure optimization: Discovery of a potent and orally available tyrosine kinase ALK inhibitor bearing the tetracyclic benzo[b]carbazolone core 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 卷号: 26, 期号: 22, 页码: 5399-5402 作者:  Han, Mei;  Wang, Chengyan;  Ji, Yinchun;  Song, Zilan;  Xing, Li 收藏  |  浏览/下载：68/0  |  提交时间：2019/01/08 EML4-ALK kinase  Oxidative metabolism  Benzo[b]carbazolone  hERG  Antitumor activity