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科研机构
上海药物研究所 [12]
内容类型
期刊论文 [12]
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2021 [1]
2020 [2]
2018 [3]
2017 [4]
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内容类型:期刊论文
专题:上海药物研究所
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Structure-Activity Relationship Study of Amidobenzimidazole Analogues Leading to Potent and Systemically Administrable Stimulator of Interferon Gene (STING) Agonists
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 3, 页码: 1649-1669
作者:
Song, Zilan
;
Wang, Xiyuan
;
Zhang, Yan
;
Gu, Wangting
;
Shen, Ancheng
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
Small molecules targeting the innate immune cGAS-STING-TBK1 signaling pathway
期刊论文
ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10, 期号: 12, 页码: 2272-2298
作者:
Ding, Chunyong
;
Song, Zilan
;
Shen, Ancheng
;
Chen, Tingting
;
Zhang, Ao
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2021/05/24
Immunotherapy
Anti-tumor
cGAS
STING
TBK1
Small molecule modulators
SOMCL-863, a novel, selective and orally bioavailable small-molecule c-Met inhibitor, exhibits antitumor activity both in vitro and in vivo (vol 351, pg 413, 2014)
期刊论文
CANCER LETTERS, 2020, 卷号: 486, 页码: 71-72
作者:
Wang, Lu
;
Ai, Jing
;
Shen, Yanyan
;
Zhang, Haotian
;
Peng, Xia
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2020/12/24
Design, synthesis and pharmacological evaluation of ALK and Hsp90 dual inhibitors bearing resorcinol and 2,4-diaminopyrimidine motifs
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 152, 页码: 76-86
作者:
Geng, Kaijun
;
Liu, Hongchun
;
Song, Zilan
;
Zhang, Chi
;
Zhang, Minmin
收藏
  |  
浏览/下载:181/0
  |  
提交时间:2019/01/08
Heat shock protein 90 (Hsp90)
Tyrosine kinase ALK
Dual inhibitor
Drug resistance
Antiproliferative activity
SOMCL-085, a novel multi-targeted FGFR inhibitor, displays potent anticancer activity in FGFR-addicted human cancer models
期刊论文
ACTA PHARMACOLOGICA SINICA, 2018, 卷号: 39, 期号: 2, 页码: 243-250
作者:
Jiang, Xi-fei
;
Dai, Yang
;
Peng, Xia
;
Shen, Yan-yan
;
Su, Yi
收藏
  |  
浏览/下载:54/0
  |  
提交时间:2019/01/08
human cancer
anticancer drug
SOMCL-085
receptor tyrosine kinase
FGFR
xenograft nude mouse model
somcl085anovelmultitargetedfgfrinhibitordisplayspotentanticanceractivityinfgfraddictedhumancancermodels
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 2, 页码: 243
作者:
Jiang Xifei
;
Dai Yang
;
Peng Xia
;
Shen Yanyan
;
Su Yi
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2020/07/01
human cancer
anticancer drug
SOMCL-085
receptor tyrosine kinase
FGFR
xenograft nude mouse model
Combining 53BP1 with BRCA1 as a biomarker to predict the sensitivity of poly(ADP-ribose) polymerase (PARP) inhibitors
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 7, 页码: 1038-1047
作者:
Yang, Zhong-min
;
Liao, Xue-mei
;
Chen, Yi
;
Shen, Yan-yan
;
Yang, Xin-ying
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2019/01/08
homologous recombination repair defects
breast cancer
ovarian cancer
TALEN
combined biomarker
simmiparib
olaparib
Poly(ADP-ribose)polymerase (PARP) inhibition and anticancer activity of simmiparib, a new inhibitor undergoing clinical trials
期刊论文
CANCER LETTERS, 2017, 卷号: 386, 页码: 47-56
作者:
Yuan, Bo
;
Ye, Na
;
Song, Shan-Shan
;
Wang, Yu-Ting
;
Song, Zilan
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Homologous recombination repair defects
Olaparib
Growth inhibition
Patient-derived xenografts
Pharmacokinetics
Design, synthesis and pharmacological evaluation of 4,5-diarylisoxazols bearing amino acid residues within the 3-amido motif as potent heat shock protein 90 (Hsp90) inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 125, 页码: 315-326
作者:
Zhang, Chi
;
Wang, Xin
;
Liu, Hongchun
;
Zhang, Minmin
;
Geng, Meiyu
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2019/01/08
Diarylisoxazole
Resorcinol
Amino acid
Hsp90 inhibitor
Antiproliferative effect
combining53bp1withbrca1asabiomarkertopredictthesensitivityofpolyadpribosepolymeraseparpinhibitors
期刊论文
actapharmacologicasinica, 2017, 卷号: 38, 期号: 7, 页码: 1036
作者:
Yang Zhongmin
;
Liao Xuemei
;
Chen Yi
;
Shen Yanyan
;
Yang Xinying
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2020/07/01
homologous recombination repair defects
breast cancer
ovarian cancer
TALEN
combined biomarker
simmiparib
olaparib
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