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浏览/检索结果: 共21条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade 期刊论文 EMBO JOURNAL, 2021, 页码: 16 作者:  Wang, Xu;  Ni, Jiahui;  You, Yan;  Feng, Guize;  Zhang, Sulin 收藏  |  浏览/下载：38/0  |  提交时间：2021/12/16 E-cadherin  IBD  intestinal barrier function  LPS release  SNX10   A validated HPLC-MS/MS method for determination of simmitecan and its metabolite chimmitecan in human plasma and its application to a pharmacokinetic study in Chinese patients with advanced solid tumor 期刊论文 JOURNAL OF SEPARATION SCIENCE, 2021, 页码: 8 作者:  Zhou, Jun;  Zhan, Yan;  Zhong, Dafang;  Chen, Xiaoyan;  Zhang, Yifan 收藏  |  浏览/下载：74/0  |  提交时间：2021/11/04 chimmitecan  mass spectrometry  pharmacokinetics  simmitecan  solid tumors   Structural insights into ligand recognition and activation of the melanocortin-4 receptor 期刊论文 CELL RESEARCH, 2021, 页码: 13 作者:  Zhang, Huibing;  Chen, Li-Nan;  Yang, Dehua;  Mao, Chunyou;  Shen, Qingya 收藏  |  浏览/下载：36/0  |  提交时间：2021/11/04 Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance (vol 19, 90, 2020) 期刊论文 MOLECULAR CANCER, 2021, 卷号: 20, 期号: 1, 页码: 1 作者:  Zhang, Tao;  Qu, Rong;  Chan, Shingpan;  Lai, Mengzhen;  Tong, Linjiang 收藏  |  浏览/下载：60/0  |  提交时间：2021/11/04 Correction to: Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance 期刊论文 Molecular Cancer, 2021, 卷号: 20, 期号: 1 作者:  Zhang,Tao;  Qu,Rong;  Chan,Shingpan;  Lai,Mengzhen;  Tong,Linjiang 收藏  |  浏览/下载：43/0  |  提交时间：2021/11/04 Pharmacodynamic, pharmacokinetic, and phase 1a study of bisthianostat, a novel histone deacetylase inhibitor, for the treatment of relapsed or refractory multiple myeloma 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Zhou, Yu-bo;  Zhang, Yang-ming;  Huang, Hong-hui;  Shen, Li-jing;  Han, Xiao-feng 收藏  |  浏览/下载：97/0  |  提交时间：2021/11/04 multiple myeloma  HDAC inhibitor  bisthianostat  pharmacodynamics  pharmacokinetics  phase 1a clinical trial  antitumor drug   Discovery of novel ketoxime ether derivatives with potent FXR agonistic activity, oral effectiveness and high liver/blood ratio 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 43, 页码: 13 作者:  Tang, Xuehang;  Ning, Mengmeng;  Ye, Yangliang;  Gu, Yipei;  Yan, Hongyi 收藏  |  浏览/下载：49/0  |  提交时间：2021/11/04 FXR agonist  Ketoxime ether  Target genes  Liver  blood ratio  Systemic activation   Discovery of SARS-CoV-2-E channel inhibitors as antiviral candidates 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 7 作者:  Wang, Yi;  Fang, Sui;  Wu, Yan;  Cheng, Xi;  Zhang, Lei-ke 收藏  |  浏览/下载：109/0  |  提交时间：2021/08/17 SARS-CoV-2  envelope protein (2-E)  cation channel  high-throughput screening (HTS)  anti-virus   Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor 期刊论文 ELIFE, 2021, 卷号: 10, 页码: 20 作者:  Zhao, Fenghui;  Zhang, Chao;  Zhou, Qingtong;  Hang, Kaini;  Zou, Xinyu 收藏  |  浏览/下载：38/0  |  提交时间：2021/08/17 Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation 期刊论文 PHARMACOLOGICAL RESEARCH, 2021, 卷号: 169, 页码: 11 作者:  Bao, Weilian;  Liu, Xiaohong;  You, Yan;  Hou, Hui;  Wang, Xu 收藏  |  浏览/下载：58/0  |  提交时间：2021/11/16 SNX10  IBD  Macrophage  PIKfyve  TBK1  PPI inhibitor