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浏览/检索结果: 共10条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Potent and Selective RIPK1 Inhibitors Targeting Dual-Pockets for the Treatment of Systemic Inflammatory Response Syndrome and Sepsis 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6 作者:  Yang, Xiangbo;  Lu, Huimin;  Xie, Hang;  Zhang, Binbin;  Nie, Tianqing 收藏  |  浏览/下载：25/0  |  提交时间：2022/01/18 Binding studies  Drug discovery  Necroptosis  RIPK1 inhibitors  Sepsis   LS-106, a novel EGFR inhibitor targeting C797S, exhibits antitumor activities both in vitro and in vivo 期刊论文 CANCER SCIENCE, 2021, 页码: 12 作者:  Liu, Yingqiang;  Lai, Mengzhen;  Li, Shan;  Wang, Yanan;  Feng, Fang 收藏  |  浏览/下载：63/0  |  提交时间：2022/01/18 C797S  epidermal growth factor receptor  fourth-generation EGFR TKI  non-small cell lung cancer  osimertinib resistance   Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11 作者:  Fan, Shijie;  Yue, Liyan;  Wan, Wei;  Zhang, Yuanyuan;  Zhang, Bidong 收藏  |  浏览/下载：81/0  |  提交时间：2021/12/16 covalent modification  probes  proteome  LC3  post-translational modification   Itraconazole and rifampicin, as CYP3A modulators but not P-gp modulators, affect the pharmacokinetics of almonertinib and active metabolite HAS-719 in healthy volunteers 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Liu, Lu;  Li, Wei;  Yang, Le;  Guo, Zi-tao;  Xue, Hao 收藏  |  浏览/下载：78/0  |  提交时间：2021/08/17 almonertinib  itraconazole  rifampicin  drug metabolism  drug interaction  CYP3A  P-gp  pharmacokinetics   miR-34a-5p regulates PINK1-mediated mitophagy via multiple modes 期刊论文 LIFE SCIENCES, 2021, 卷号: 276, 页码: 13 作者:  Tai, Yusi 收藏  |  浏览/下载：53/0  |  提交时间：2021/08/17 Mitophagy  PINK1  miR-34a-5p  CDS  Non-seed region   Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry 期刊论文 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2021, 卷号: 198, 页码: 7 作者:  Pan, Lu-lu;  Chen, Tao;  Hui, Min;  Wang, Shuo;  Fu, Li 收藏  |  浏览/下载：134/0  |  提交时间：2021/05/24 LC-MS/MS  Forsythin  Aglycone glucuronide  Aglycone sulfate  Pharmacokinetics   Pharmacokinetics-based identification of pseudoaldosterogenic compounds originating from Glycyrrhiza uralensis roots (Gancao) after dosing LianhuaQingwen capsule 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 18 作者:  Lan, Xiao-fang;  Olaleye, Olajide E.;  Lu, Jun-lan;  Yang, Wei;  Du, Fei-fei 收藏  |  浏览/下载：76/0  |  提交时间：2021/06/11 LianhuaQingwen  glycyrrhetic acid  24-hydroxyglycyrrhetic acid  Gancao-induced pseudoaldosteronism  licorice-induced pseudoaldosteronism  11β  -hydroxysteroid dehydrogenase 2  COVID-19  colonic microbiota   A 36-week multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 3 clinical trial of sodium oligomannate for mild-to-moderate Alzheimer’s dementia 期刊论文 Alzheimer's Research & Therapy, 2021, 卷号: 13, 期号: 1 作者:  Xiao,Shifu;  Chan,Piu;  Wang,Tao;  Hong,Zhen;  Wang,Shuzhen 收藏  |  浏览/下载：152/0  |  提交时间：2021/05/24 Sodium oligomannate  Efficacy  Safety  Alzheimer’s disease  Clinical trial   Discovery of New alpha-Glucosidase Inhibitors: Structure-Based Virtual Screening and Biological Evaluation 期刊论文 FRONTIERS IN CHEMISTRY, 2021, 卷号: 9, 页码: 9 作者:  Liu, Shan-Kui;  Hao, Haifang;  Bian, Yuan;  Ge, Yong-Xi;  Lu, Shengyuan 收藏  |  浏览/下载：59/0  |  提交时间：2021/05/24 α  -glycosidase  virtual screening  cytotoxicity  type 2 diabetes  molecular docking   miR-552-3p modulates transcriptional activities of FXR and LXR to ameliorate hepatic glycolipid metabolism disorder 期刊论文 JOURNAL OF HEPATOLOGY, 2021, 卷号: 74, 期号: 1, 页码: 8-19 作者:  Fan, Lei;  Lai, Rongtao;  Ma, Ningning;  Dong, Yunxia;  Li, Yu 收藏  |  浏览/下载：42/0  |  提交时间：2021/05/24 miR-552-3p  Transcriptional gene regulation  Intranuclear miRNAs  Glycolipid metabolic disease  NR1 subfamily