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浏览/检索结果: 共34条，第1-10条 帮助 限定条件 发表日期：2021    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Li, Teng-teng;  Peng, Cheng;  Wang, Ji-qiu;  Xu, Zhi-jian;  Su, Ming-bo 收藏  |  浏览/下载：43/0  |  提交时间：2022/01/18 DPP4  distal mutation  enzymatic activity  molecular dynamics simulation  structure-function mechanism   Scalable Process for Making 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid Using Methylene as the Protecting Group 期刊论文 ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2021, 卷号: 25, 期号: 11, 页码: 2447-2452 作者:  Xu, Wanbin;  Gong, Xudong;  Odilov, Abdullajon;  Hu, Tianwen;  Jiang, Xiangrui 收藏  |  浏览/下载：53/0  |  提交时间：2022/01/18 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid  lifitegrast  methylene  atom utilization   Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein 期刊论文 ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 11 作者:  Fan, Shijie;  Yue, Liyan;  Wan, Wei;  Zhang, Yuanyuan;  Zhang, Bidong 收藏  |  浏览/下载：81/0  |  提交时间：2021/12/16 covalent modification  probes  proteome  LC3  post-translational modification   Genetically-engineered "all-in-one" vaccine platform for cancer immunotherapy 期刊论文 ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 11, 页码: 3622-3635 作者:  Wu, Aihua;  Chen, Yingzhi;  Wang, Hairui;  Chang, Ya;  Zhang, Meng 收藏  |  浏览/下载：27/0  |  提交时间：2022/01/18 Trichosanthin  Legumain  TRP2  Transcutaneous immunization  Adjuvant  Cancer vaccine  Protein engineering   Discovery of chiral N-2 '-aryletheryl-1 '-alkoxy-ethyl substituted arylisoquinolones with anti-inflammatory activity from the nucleophilic addition reactions of the thiophenols and oxazolinium 期刊论文 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 222, 页码: 11 作者:  Li, Bo;  Li, Heng;  Zhu, Zhengdan;  Xiang, Caigui;  Xu, Zhijian 收藏  |  浏览/下载：103/0  |  提交时间：2021/11/04 Anti-inflammatory activity  TNF alpha  ER beta  IBD Arylisoquinolones   Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 19, 页码: 14647-14663 作者:  Han, Xu;  Song, Ning;  Saidahmatov, Abdusaid;  Wang, Peipei;  Wang, Yong 收藏  |  浏览/下载：17/0  |  提交时间：2021/12/16 Novel tetrahydrobenzo[b]thiophen-2-yl)urea derivatives as novel alpha-glucosidase inhibitors: Synthesis, kinetics study, molecular docking, and in vivo anti-hyperglycemic evaluation 期刊论文 BIOORGANIC CHEMISTRY, 2021, 卷号: 115, 页码: 17 作者:  Xie, Hong-Xu;  Zhang, Juan;  Li, Yue;  Zhang, Jin-He;  Liu, Shan-Kui 收藏  |  浏览/下载：69/0  |  提交时间：2021/11/04 Tetrahydrobenzo[b]thiophen-2-yl)urea  alpha-Glucosidase inhibitors  Non-competitive inhibitor  Molecular docking  Anti-hyperglycaemic activity  Type 2 diabetes   Discovery of potential small molecular SARS-CoV-2 entry blockers targeting the spike protein 期刊论文 ACTA PHARMACOLOGICA SINICA, 2021, 页码: 9 作者:  Wang, Lin;  Wu, Yan;  Yao, Sheng;  Ge, Huan;  Zhu, Ya 收藏  |  浏览/下载：89/0  |  提交时间：2021/11/04 SARS-CoV-2  natural products  virtual screening  spike protein  protein-protein interaction modulators   Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy 期刊论文 CHEMICAL SCIENCE, 2021, 页码: 9 作者:  Dou, Wei-Tao;  Xu, Fugui;  Xu, Chen-Xi;  Gao, Jie;  Ru, Hong-Bo 收藏  |  浏览/下载：81/0  |  提交时间：2021/08/17 Structural basis for chemokine recognition and receptor activation of chemokine receptor CCR5 期刊论文 NATURE COMMUNICATIONS, 2021, 卷号: 12, 期号: 1, 页码: 12 作者:  Zhang, Hui;  Chen, Kun;  Tan, Qiuxiang;  Shao, Qiang;  Han, Shuo 收藏  |  浏览/下载：54/0  |  提交时间：2021/08/17