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科研机构
上海药物研究所 [8]
内容类型
期刊论文 [8]
发表日期
2020 [8]
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发表日期:2020
专题:上海药物研究所
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A novel salviadione derivative, compound 15a, attenuates diabetes-induced renal injury by inhibiting NF-kappa B-mediated inflammatory responses
期刊论文
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2020, 卷号: 409, 页码: 11
作者:
Li, Li
;
Ding, Chunyong
;
Zou, Chunpeng
;
Xiong, Zhi
;
Zhu, Weiwei
收藏
  |  
浏览/下载:102/0
  |  
提交时间:2021/05/24
Salviadione derivative 15a
Diabetic nephropathy
Inflammation
Macrophage infiltration
Fibrosis
Nuclear factor-kappa B
Cytokines
Anti-PD-L1 mediating tumor-targeted codelivery of liposomal irinotecan/JQ1 for chemo-immunotherapy
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 8
作者:
He, Zhi-di
;
Zhang, Meng
;
Wang, Yong-hui
;
He, Yang
;
Wang, Hai-rui
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/05/24
tumor-targeted delivery
immunogenic cell death
PD-1
PD-L1 blockade
tumor immune microenvironment
irinotecan
JQ1
immune checkpoint
Co-delivery of all-trans-retinoic acid and doxorubicin for cancer therapy with synergistic inhibition of cancer stem cells (vol 37, pg 405, 2015)
期刊论文
BIOMATERIALS, 2020, 卷号: 263, 页码: 1
作者:
Sun, Rong
;
Liu, Yang
;
Li, Shi-Yong
;
Shen, Song
;
Du, Xiao-Jiao
收藏
  |  
浏览/下载:92/0
  |  
提交时间:2020/12/21
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (ROR gamma t) modulators: insights into different protein behaviors with "short" and "long" inverse agonists
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11
作者:
Yu, Ming-cheng
;
Yang, Feng
;
Ding, Xiao-yu
;
Sun, Nan-nan
;
Jiang, Zheng-yuan
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2020/12/24
RORγ
t
cocrystal structures
MD simulation
“
short”
inverse agonists
agonists
“
long”
inverse agonists
Exploring the protective effects of Danqi Tongmai tablet on acute myocardial ischemia rats by comprehensive metabolomics profiling
期刊论文
PHYTOMEDICINE, 2020, 卷号: 74, 页码: 9
作者:
Li Zhenwei
;
Hou Jinjun
;
Deng Yanping
;
Zhi Haijuan
;
Wu Wenyong
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/12/24
Danqi Tongmai tablet
Acute myocardial ischemia
Metabolomics
Lipidomics
Network pharmacology
Sarsasapogenin improves adipose tissue inflammation and ameliorates insulin resistance in high-fat diet-fed C57BL/6J mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 10
作者:
Yu, Yan-yan
;
Cui, Shi-chao
;
Zheng, Tian-nan
;
Ma, Hai-jian
;
Xie, Zhi-fu
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2020/12/24
insulin resistance
sarsasapogenin
adipose tissue inflammation
macrophage-adipocyte crosstalk
IKK/NF-kappa B
JNK
Inhibition of human thrombin by the constituents of licorice: inhibition kinetics and mechanistic insights through in vitro and in silico studies
期刊论文
RSC ADVANCES, 2020, 卷号: 10, 期号: 7, 页码: 3626-3635
作者:
Shi, Cheng-Cheng
;
Chen, Tian-Ran
;
Zhang, Qi-Hua
;
Wei, Ling-Hua
;
Huang, Chao
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Berberine derivatives with a long alkyl chain branched by hydroxyl group and methoxycarbonyl group at 9-position show improved anti-proliferation activity and membrane permeability in A549 cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Liu, Yi
;
Zhu, Ke-xin
;
Cao, Lei
;
Xie, Zhi-fu
;
Gu, Min
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2020/07/01
berberine
anticancer
membrane permeability
apoptosis
mitochondria
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