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浏览/检索结果: 共24条，第1-10条 帮助 限定条件 发表日期：2020    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes 期刊论文 FRONTIERS IN ENDOCRINOLOGY, 2020, 卷号: 11, 页码: 13 作者:  Duan, Ya-Nan;  Ge, Xiang;  Jiang, Hao-Wen;  Zhang, Hong-Jie;  Zhao, Yu 收藏  |  浏览/下载：42/0  |  提交时间：2021/05/24 diphyllin  obesity  brown adipocyte  differentiation  thermogenesis  V-ATPase   Clinical application of pyrrole-hemoglobin adducts as a biomarker of pyrrolizidine alkaloid exposure in humans 期刊论文 ARCHIVES OF TOXICOLOGY, 2020, 页码: 7 作者:  Ma, Jiang;  Zhang, Wei;  He, Yisheng;  Zhu, Lin;  Zhang, Chunyuan 收藏  |  浏览/下载：44/0  |  提交时间：2020/12/24 Pyrrolizidine alkaloids  Liver injury  Diagnostic biomarkers  Pyrrole-hemoglobin adducts  Pyrrole-plasma protein adducts   Structure-based drug optimization and biological evaluation of tetrahydroquinolin derivatives as selective and potent CBP bromodomain inhibitors 期刊论文 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 卷号: 30, 期号: 22, 页码: 7 作者:  Bi, Xiaoyang;  Chen, Yu;  Sun, Zhongya;  Lu, Wenchao;  Xu, Pan 收藏  |  浏览/下载：21/0  |  提交时间：2021/05/24 Drug design  CBP  Bromodomain  Inhibitor  Acute myeloid leukemia   Tu-San-Qi (Gynura japonica): the culprit behind pyrrolizidine alkaloid-induced liver injury in China 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 11 作者:  Zhu, Lin;  Zhang, Chun-yuan;  Li, Dong-ping;  Chen, Hu-biao;  Ma, Jiang 收藏  |  浏览/下载：18/0  |  提交时间：2020/12/24 herb-induced liver injury  hepatic sinusoidal obstruction syndrome  pyrrolizidine alkaloids  Tu-San-Qi  Gynura japonica   New cembrane-type diterpenoids from the South China Sea soft coral Sinularia crassa and their alpha-glucosidase inhibitory activity 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 104, 页码: 6 作者:  Wu, Meng-Jun;  Wang, Hong;  Jiang, Cheng-Shi;  Guo, Yue-Wei 收藏  |  浏览/下载：9/0  |  提交时间：2021/05/24 Sinularia crassa  Cembranoid  Modified Mosher's method  ECD calculation  alpha-Glucosidase inhibitor   Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao 收藏  |  浏览/下载：29/0  |  提交时间：2020/12/21 Deep Learning Enhancing Kinome-Wide Polypharmacology Profiling: Model Construction and Experiment Validation 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 16, 页码: 8723-8737 作者:  Li, Xutong;  Li, Zhaojun;  Wu, Xiaolong;  Xiong, Zhaoping;  Yang, Tianbiao 收藏  |  浏览/下载：23/0  |  提交时间：2020/12/21 Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction 期刊论文 ORGANIC CHEMISTRY FRONTIERS, 2020, 卷号: 7, 期号: 16, 页码: 2269-2277 作者:  Fu, Zunyun;  Li, Xutong;  Wang, Zhaohui;  Li, Zhaojun;  Liu, Xiaohong 收藏  |  浏览/下载：36/0  |  提交时间：2020/12/24 Identification and characterization of isocitrate dehydrogenase 1 (IDH1) as a functional target of marine natural product grincamycin B 期刊论文 ACTA PHARMACOLOGICA SINICA, 2020, 页码: 13 作者:  Wang, Zheng;  Li, Zeng-xia;  Zhao, Wen-cao;  Huang, Hong-bo;  Wang, Jia-qi 收藏  |  浏览/下载：85/0  |  提交时间：2020/12/24 grincamycin B  marine natural product  isocitrate dehydrogenase 1  apoptosis  ER stress  intracellular ROS  Zebrafish embryos  hematological malignancies   Design, synthesis, and biological evaluation of tetrahydroquinolin derivatives as potent inhibitors of CBP bromodomain 期刊论文 BIOORGANIC CHEMISTRY, 2020, 卷号: 101, 页码: 11 作者:  Chen, Yu;  Bi, Xiaoyang;  Zhang, Fengcai;  Sun, Zhongya;  Xu, Pan 收藏  |  浏览/下载：24/0  |  提交时间：2020/12/24 In silico screening  Drug design  CBP  Bromodomain  Inhibitor  Acute Myeloblastic Leukemia