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浏览/检索结果: 共13条，第1-10条 帮助 限定条件 发表日期：2019    专题：上海药物研究所    第一署名单位    第一作者单位    通讯作者单位     已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression 期刊论文 NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 14 作者:  Shi, Yulin;  Fan, Songqing;  Wu, Mengge;  Zuo, Zhixiang;  Li, Xingyang 收藏  |  浏览/下载：61/0  |  提交时间：2020/07/01 Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1279-1291 作者:  Fan, Lei;  Qiu, Xiao-xia;  Zhu, Zhi-yuan;  Lv, Jian-lu;  Lu, Jian 收藏  |  浏览/下载：19/0  |  提交时间：2020/07/01 Alzheimer's disease  nitazoxanide  autophagy  inflammation  APP/PS1 transgenic mice   Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice 期刊论文 ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 9, 页码: 1193-1204 作者:  Zhou, Ting-ting;  Zhao, Tong;  Ma, Fei;  Zhang, Yi-nan;  Jiang, Jing 收藏  |  浏览/下载：27/0  |  提交时间：2020/07/01 type 2 diabetes mellitus  hepatic gluconeogenesis  AMPK signaling pathway  (E)-3-(2-(quinoline-4-yl)vinyl)-1H-indol-6-ol (QVO)  4-[2-(1H-indol-3-yl)vinyl]quinoline (IVQ)  prodrug   Preclinical evaluation of 3D185, a novel potent inhibitor of FGFR1/2/3 and CSF-1R, in FGFR-dependent and macrophage-dominant cancer models 期刊论文 JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2019, 卷号: 38, 期号: 1, 页码: 16 作者:  Peng, Xia;  Hou, Pengcong;  Chen, Yi;  Dai, Yang;  Ji, Yinchun 收藏  |  浏览/下载：7/0  |  提交时间：2020/07/01 Kinase inhibitor  FGFR  CSF-1R  Tumor microenvironment   Inhibition of the BET family reduces its new target gene IDO1 expression and the production of L-kynurenine 期刊论文 CELL DEATH & DISEASE, 2019, 卷号: 10, 页码: 13 作者:  Tian, Chang-Qing;  Chen, Lin;  Chen, Hua-Dong;  Huan, Xia-Juan;  Hu, Jian-Ping 收藏  |  浏览/下载：22/0  |  提交时间：2020/07/01 Oxidative Aromatization of 3,4-Dihydroquinolin-2(1H)-ones to Quinolin-2(1H)-ones Using Transition-Metal-Activated Persulfate Salts 期刊论文 JOURNAL OF ORGANIC CHEMISTRY, 2019, 卷号: 84, 期号: 13, 页码: 8702-8709 作者:  Chen, Weiming;  Sun, Changliang;  Zhang, Yan;  Hu, Tianwen;  Zhu, Fuqiang 收藏  |  浏览/下载：50/0  |  提交时间：2020/07/01 Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990 作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei 收藏  |  浏览/下载：40/0  |  提交时间：2020/07/01 TGF-beta 1/p65/MAT2A pathway regulates liver fibrogenesis via intracellular SAM 期刊论文 EBIOMEDICINE, 2019, 卷号: 42, 页码: 458-469 作者:  Wang, Kuifeng;  Fang, Shanhua;  Liu, Qian;  Gao, Jing;  Wang, Xiaoning 收藏  |  浏览/下载：23/0  |  提交时间：2020/07/01 Liver fibrosis  TGF-beta 1  MAT2A  p65  SAM   Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure-activity relationship, crystal structural characterization and and in vivo study 期刊论文 ACTA PHARMACEUTICA SINICA B, 2019, 卷号: 9, 期号: 2, 页码: 351-368 作者:  Wei, Peng;  Liu, Bo;  Wang, Ruifeng;  Gao, Yinglei;  Li, Lanlan 收藏  |  浏览/下载：109/0  |  提交时间：2020/07/01 Fibroblast growth factor  Tyrosine kinase receptor  Structure-based  Crystallography  Selectivity  Hybrid  5-Hydrosulfonyl-5H- pyrrolo[2.3-b]pyrazine  Inhibitor   Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice 期刊论文 JOURNAL OF ENDOCRINOLOGY, 2019, 卷号: 240, 期号: 2, 页码: 195-214 作者:  Du, Te;  Yang, Liu;  Xu, Xu;  Shi, Xiaofan;  Xu, Xin 收藏  |  浏览/下载：105/0  |  提交时间：2019/01/08 vincamine  GPR40  beta-cell function  insulin secretion  type 2 diabetes